Cited by 121Cancer-related Molecular PathwaysChemical Synthesis and AnalysisProtein Structure and Dynamics

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A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction

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Liu, Min, Pazgier, Marzena, Li, Changqing, Yuan, Weirong, Li, Chong, Lu, Wuyuan·2010·Angewandte Chemie International Edition

DOI 10.1002/anie.201000329PMC PMC3359147

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Abstract

Throwing tumors a left-hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror-image phage display identified a high-affinity D-peptide ligand of MDM2 (see structure) that could be developed into a potent and protease-resistant p53 activator with potential antitumor activity.

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Authors: Liu, M., Pazgier, M., Li, C., Yuan, W., Li, C., & Lu, W.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Lu, Wuyuan
ORCID: Liu, Min
Pazgier, Marzena
Li, Changqing
Li, Chong
Lu, Wuyuan
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2010-05-06
Volume: 49
Issue: 21
Pages: 3649-3652
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.201000329
PMC: PMC3359147
OpenAlex: W2107850581
Cited by: 115
References: 31
Citations by year: 2026: 4 · 2025: 10 · 2024: 11 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 4 · 2012: 8
FWCI: 2.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI 061482, AI-072732, R01AI072732, R01AI061482)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords: p53-MDM2 interaction, MDM2, p53 activation, peptide inhibitors, protease resistance, tumor suppressor, cancer therapy, protein-protein interaction inhibition
MeSH terms: Amino Acid Sequence, Enzyme Inhibitors, Humans, Ligands, Molecular Sequence Data, Peptides, Stereoisomerism, Drug Design, Proto-Oncogene Proteins c-mdm2

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A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction

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