The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Nanotoxicology: An Interdisciplinary Challenge
Abstract
The increasing consumption of products containing nanomaterials that can be currently observed and forecasts of new developments and applications fan the fear of individuals and organizations regarding new risks to health. Considering experiences gained from previous technology developments, such fears are not completely unfounded. But are they really justified? And is it justified, moreover, to speak of “nanotoxicology” as a new discipline? This Review seeks to cast light on the phenomena that may occur as nanoobjects interact with cells, tissues, and organisms. Furthermore, we will demonstrate that the many data made available on the biological effects of nanomaterials do not always come from studies that can be considered reliable. We will point out the aspect of reliability with specific examples from the literature and will not address specific (nano)materials. In particular, inadequate methods will be described together with recommendations how to avoid this in the future, thereby contributing to a sustainable improvement of the available data.
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“As studies with engineered nanoparticles have suggested and investigations of plastic particles are starting to indicate, toxicity induced by micro-nano particles is not only dose-dependent but also related to particle physicochemical characteristics and their effect on cellular interactions and uptake (81, 82).”
From Rapid single-particle chemical imaging of nanoplastics by SRS microscopy (2024) · cites this paper as [81]
Citations
Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Luminescent Carbon Nanodots: Emergent Nanolights
Baker, S. N., & Baker, G. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906623 · Cited by 4,985
Cedervall, T., Lynch, I., Lindman, S., Berggård, T., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608582104 · Cited by 3,281
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,037
Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645
Translocation of inhaled ultrafine particles to the brain
Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., & Cox, C. (2004) · Inhalation Toxicology · doi:10.1080/08958370490439597 · Cited by 2,606
Xia, T., Kovochich, M., Liong, M., Mädler, L., Gilbert, B., Shi, H., Yeh, J. I., Zink, J. I., & Nel, A. E. (2008) · ACS Nano · doi:10.1021/nn800511k · Cited by 2,470
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
Auffan, M., Rose, J., Bottero, J., Lowry, G. V., Jolivet, J., & Wiesner, M. R. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.242 · Cited by 2,026
Flagged first, then by citations
Research works printed but not linked: 8
- Krug H. F., 2007, Arbeitsmed. Sozialmed. Umweltmed., 42, 4
- Brune H., 2006, Nanotechnology—Assessment and Perspectives
- Lippert H., 2000, Lehrbuch Anatomie, 5th ed., 803
- 10.1289/ehp.0901200 · DOI
- Brüske‐Hohlfeld I., 2008, Nanotechnology: Environmental Aspects, Vol. 2, 267
- N. A. Monteiro‐Riviere J. E. Riviere inProceedings—Nanotechnology and the Environment: Applications and Implications Progress Review Workshop III U.S. Environmental Protection Agency Office of Research and Development Washington 2005.
- Cai R., 1992, Cancer Res., 52, 2346
- Krug H. F., 2006, Nanomaterials—Toxicity, Health and Environmental Issues, Vol. 5, 153
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Palomäki, J. (2014) · Työväentutkimus Vuosikirja
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Gurny, R., & Leroux, J. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.07.014
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Metadata
- Authors
- Krug, H. F., & Wick, P.
- Affiliations
- Empa (CH)
- Corresponding author
- Krug, Harald F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-01-11
- Volume
- 50
- Issue
- 6
- Pages
- 1260-1278
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2169703093
- Cited by
- 556
- References
- 166
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 28 · 2023: 23 · 2022: 25 · 2021: 31 · 2020: 32 · 2019: 30 · 2018: 41 · 2017: 40 · 2016: 30 · 2015: 45 · 2014: 62 · 2013: 70 · 2012: 51
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- nanotoxicology, nanomaterials, nanomaterial-cell interactions, health risks, research reliability, methodological quality, data quality improvement, interdisciplinary research
- MeSH terms
- Blood-Brain Barrier, Humans, Lung, Skin, Nanostructures
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