The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Nanotoxicology: An Interdisciplinary Challenge
Abstract
The increasing consumption of products containing nanomaterials that can be currently observed and forecasts of new developments and applications fan the fear of individuals and organizations regarding new risks to health. Considering experiences gained from previous technology developments, such fears are not completely unfounded. But are they really justified? And is it justified, moreover, to speak of “nanotoxicology” as a new discipline? This Review seeks to cast light on the phenomena that may occur as nanoobjects interact with cells, tissues, and organisms. Furthermore, we will demonstrate that the many data made available on the biological effects of nanomaterials do not always come from studies that can be considered reliable. We will point out the aspect of reliability with specific examples from the literature and will not address specific (nano)materials. In particular, inadequate methods will be described together with recommendations how to avoid this in the future, thereby contributing to a sustainable improvement of the available data.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As studies with engineered nanoparticles have suggested and investigations of plastic particles are starting to indicate, toxicity induced by micro-nano particles is not only dose-dependent but also related to particle physicochemical characteristics and their effect on cellular interactions and uptake (81, 82).”
From Rapid single-particle chemical imaging of nanoplastics by SRS microscopy (2024) · cites this paper as [81]
Citations
Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Luminescent Carbon Nanodots: Emergent Nanolights
Baker, S. N., & Baker, G. A. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906623 · Cited by 4,985
Cedervall, T., Lynch, I., Lindman, S., Berggård, T., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608582104 · Cited by 3,281
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,109
Poland, C. A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W. A. H., Seaton, A., Stone, V., Brown, S., MacNee, W., & Donaldson, K. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.111 · Cited by 2,645
Translocation of inhaled ultrafine particles to the brain
Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., & Cox, C. (2004) · Inhalation Toxicology · doi:10.1080/08958370490439597 · Cited by 2,606
Xia, T., Kovochich, M., Liong, M., Mädler, L., Gilbert, B., Shi, H., Yeh, J. I., Zink, J. I., & Nel, A. E. (2008) · ACS Nano · doi:10.1021/nn800511k · Cited by 2,470
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
Auffan, M., Rose, J., Bottero, J., Lowry, G. V., Jolivet, J., & Wiesner, M. R. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.242 · Cited by 2,026
Lam, C.-W. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg243 · Cited by 1,992
Xia, T., Kovochich, M., Brant, J. A., Hotze, M., Sempf, J. M., Oberley, T. D., Sioutas, C., Yeh, J. I., Wiesner, M. R., & Nel, A. E. (2006) · Nano Letters · doi:10.1021/nl061025k · Cited by 1,931
Exposure Modeling of Engineered Nanoparticles in the Environment
Mueller, N. C., & Nowack, B. (2008) · Environmental Science & Technology · doi:10.1021/es7029637 · Cited by 1,828
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Valavanidis, A., Fiotakis, K., & Vlachogianni, T. (2008) · Journal of Environmental Science and Health Part C · doi:10.1080/10590500802494538 · Cited by 1,536
Comparative Pulmonary Toxicity Assessment of Single-wall Carbon Nanotubes in Rats
Warheit, D. B. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg228 · Cited by 1,531
Geiser, M., Rothen‐Rutishauser, B., Kapp, N., Schürch, S., Kreyling, W. G., Schulz, H., Semmler, M., Hof, V. I., Heyder, J., & Gehr, P. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8006 · Cited by 1,408
Oberdörster, E. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7021 · Cited by 1,393
Brunner, T. J., Wick, P., Manser, P., Spohn, P., Grass, R. N., Limbach, L. K., Bruinink, A., & Stark, W. J. (2006) · Environmental Science & Technology · doi:10.1021/es052069i · Cited by 1,385
Self-citationExploiting lymphatic transport and complement activation in nanoparticle vaccines
Reddy, S. T., van der Vlies, A. J., Simeoni, E., Angeli, V., Randolph, G. J., O’Neil, C. P., Lee, L. K., Swartz, M. A., & Hubbell, J. A. (2007) · Nature Biotechnology · doi:10.1038/nbt1332 · Cited by 1,355
The potential risks of nanomaterials: a review carried out for ECETOC.
Borm, P. J. A., Robbins, D. J., Haubold, S., Kuhlbusch, T. A. J., Fissan, H. J., Donaldson, K., Schins, R. P. F., Stone, V., Kreyling, W. G., Lademann, J. M., et al. (2006) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-3-11 · Cited by 1,344
Brown, D. M., Wilson, M., MacNee, W., Stone, V., & Donaldson, K. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9240 · Cited by 1,330
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Shvedova, A. A., Kisin, E. R., Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. I., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00084.2005 · Cited by 1,312
Nanomedicine—Challenge and Perspectives
Riehemann, K., Schneider, S. W., Luger, T. A., Godin, B., Mauro Ferrari, B., & Fuchs, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802585 · Cited by 1,310
Applications and implications of nanotechnologies for the food sector
Chaudhry, Q., Scotter, M. J., Blackburn, J., Ross, B. L., Boxall, A. B. A., Castle, L., Aitken, R. J., & Watkins, R. (2008) · Food Additives & Contaminants Part A · doi:10.1080/02652030701744538 · Cited by 1,290
Shvedova, A. A., Castranova, V., Kisin, E. R., Schwegler‐Berry, D., Murray, A. R., Gandelsman, V., Maynard, A., & Baron, P. A. (2003) · Journal of Toxicology and Environmental Health · doi:10.1080/713853956 · Cited by 1,245
Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms
Beyersmann, D., & Hartwig, A. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0313-y · Cited by 1,209
Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., & Alexander, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj130 · Cited by 1,167
Wang, J., Zhou, G.-D., Chen, C., YU, H., WANG, T., Ma, Y., JIA, G., Gao, Y., Li, B., & SUN, J. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.12.001 · Cited by 1,145
Respiratory toxicity of multi-wall carbon nanotubes
Muller, J., Huaux, F., Moreau, N., Misson, P., Heilier, J.-F., Delos, M., Arras, M., Fonseca, A., Nagy, J. B., & Lison, D. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.01.008 · Cited by 1,123
Cellular Toxicity of Carbon-Based Nanomaterials
Magrez, A., Kasas, S., Salicio, V., Pasquier, N., Seo, J. W., Celio, M. R., Catsicas, S., Schwaller, B., & Laszlo Forro, C. (2006) · Nano Letters · doi:10.1021/nl060162e · Cited by 1,123
The Differential Cytotoxicity of Water-Soluble Fullerenes
Sayes, C. M., Fortner, J. D., Guo, W., Lyon, D. Y., Boyd, A. M., Ausman, K. D., Tao, Y. J., Sitharaman, B., Wilson, L. J., Hughes, J. B., et al. (2004) · Nano Letters · doi:10.1021/nl0489586 · Cited by 1,090
Pulskamp, K., Diabaté, S., & Krug, H. F. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.11.001 · Cited by 1,014
Self-citationOops they did it again! Carbon nanotubes hoax scientists in viability assays
Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
Self-citationAcute toxicological effects of copper nanoparticles in vivo
Chen, Z., Meng, H., Xing, G., Chen, C., Zhao, Y., Jia, G., Wang, T., Yuan, H. Y., Ye, C., Zhao, F., et al. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.10.003 · Cited by 967
Nanominerals, Mineral Nanoparticles, and Earth Systems
Hochella, M. F., Lower, S. K., Maurice, P. A., Penn, R. L., Sahai, N., Sparks, D. L., & Twining, B. S. (2008) · Science · doi:10.1126/science.1141134 · Cited by 961
Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdörster, G., & Ziesenis, A. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/00984100290071649 · Cited by 951
Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size
Karlsson, H. L., Gustafsson, J., Cronholm, P., & Möller, L. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.03.014 · Cited by 949
Oxidative stress-induced DNA damage by particulate air pollution
Risom, L., Möller, P., & Loft, S. H. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.012 · Cited by 914
Limbach, L. K., Wick, P., Manser, P., Grass, R. N., Bruinink, A., & Stark, W. J. (2007) · Environmental Science & Technology · doi:10.1021/es062629t · Cited by 900
Self-citationHandy, R. D., Owen, R., & Valsami‐Jones, E. (2008) · Ecotoxicology · doi:10.1007/s10646-008-0206-0 · Cited by 890
Sayes, C. M., Wahi, R. K., Kurian, P. A., Liu, Y., West, J. L., Ausman, K. D., Warheit, D. B., & Colvin, V. L. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj197 · Cited by 860
Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro
Sayes, C. M., Liang, F., Hudson, J. L., Mendez, J. S., Guo, W., Beach, J. M., Moore, V. C., Doyle, C. D., West, J. L., Billups, W. E., et al. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.08.011 · Cited by 856
Clinical applications of magnetic nanoparticles for hyperthermia
Thiesen, B., & Jordan, A. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802104757 · Cited by 829
The degree and kind of agglomeration affect carbon nanotube cytotoxicity
Wick, P., Manser, P., Limbach, L. K., Dettlaff‐Weglikowska, U., Krumeich, F., Roth, S., Stark, W. J., & Bruinink, A. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.08.019 · Cited by 829
Self-citationMolecular imaging in drug discovery and development
Rudin, M., & Weissleder, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1007 · Cited by 811
Maynard, A., Baron, P. A., Foley, M., Shvedova, A. A., Kisin, E. R., & Castranova, V. (2004) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390490253688 · Cited by 763
Multi-walled carbon nanotube interactions with human epidermal keratinocytes
Monteiro-Riviere, N. A., Nemanich, R. J., Inman, A. O., Wang, Y. Y., & Riviere, J. E. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2004.11.004 · Cited by 756
Late lessons from early warnings: the precautionary principle 1896-2000
MacGarvin, M., Lambert, B. E., Infante, P. F., Greenberg, M., Gee, D., Koppe, J. G., Keys, J. G., Farman, J. C., Ibarreta, D., Swan, S. H., et al. (2001) · Figshare · Cited by 754
Nanoparticulate Functional Materials
Goesmann, H., & Feldmann, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903053 · Cited by 747
Are Diamond Nanoparticles Cytotoxic?
Schrand, A. M., Huang, H., Carlson, C., Schlager, J. J., O̅sawa, E., Hussain, S. M., & Dai, L. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp066387v · Cited by 716
Toxicology for the twenty-first century
Härtung, T. (2009) · Nature · doi:10.1038/460208a · Cited by 686
Barrier Capacity of Human Placenta for Nanosized Materials
Wick, P., Malek, A., Manser, P., Meili, D., Maeder-Althaus, X., Diener, L., Diener, P., Zisch, A. H., Krug, H. F., & von Mandach, U. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901200 · Cited by 673
Self-citationThe normal human lung: ultrastructure and morphometric estimation of diffusion capacity
Gehr, P., Bachofen, M., & Weibel, E. R. (1978) · Respiration Physiology · doi:10.1016/0034-5687(78)90104-4 · Cited by 655
Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety
Nohynek, G. J., Lademann, J., Ribaud, C., & Roberts, M. S. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440601177780 · Cited by 644
Warheit, D. B., Webb, T. R., Reed, K. L., Frerichs, S., & Sayes, C. M. (2006) · Toxicology · doi:10.1016/j.tox.2006.11.002 · Cited by 642
Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles
Lovern, S. B., & Klaper, R. D. (2006) · Environmental Toxicology and Chemistry · doi:10.1897/05-278r.1 · Cited by 600
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron
Kagan, V. E., Tyurina, Y. Y., Tyurin, V. A., Konduru, N. V., Potapovich, A. I., Osipov, A. N., Kisin, E. R., Schwegler‐Berry, D., Mercer, R. R., Castranova, V., et al. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.02.001 · Cited by 560
Nanotechnology Safety Concerns Revisited
Stern, S. T., & McNeil, S. E. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfm169 · Cited by 560
George, S., Pokhrel, S., Xia, T., Gilbert, B., Ji, Z., Schowalter, M., Rosenauer, A., Damoiseaux, R. D., Bradley, K. A., Mädler, L., et al. (2009) · ACS Nano · doi:10.1021/nn901503q · Cited by 547
Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients
Dunford, R., Salinaro, A., Cai, L., Serpone, N., Horikoshi, S., Hidaka, H., & Knowland, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01356-2 · Cited by 540
Hong, J., Heller, D. A., Sharma, R., & Strano, M. S. (2009) · ACS Nano · doi:10.1021/nn800532m · Cited by 539
Rothen‐Rutishauser, B., Schürch, S., Haenni, B., Kapp, N., & Gehr, P. (2006) · Environmental Science & Technology · doi:10.1021/es0522635 · Cited by 535
Panyam, J., Dali, M. M., Sahoo, S. K., Ma, W., Chakravarthi, S. S., Amidon, G. L., Levy, R. J., & Labhasetwar, V. D. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00328-6 · Cited by 535
Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties
Ryman-Rasmussen, J. P., Riviere, J. E., & Monteiro-Riviere, N. A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj122 · Cited by 535
Gojová, A., Guo, B., Kota, R. S., Rutledge, J. C., Kennedy, I. M., & Barakat, A. I. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8497 · Cited by 519
Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro
Samberg, M. E., Oldenburg, S. J., & Monteiro-Riviere, N. A. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901398 · Cited by 514
Warheit, D. B., Webb, T. R., Sayes, C. M., Colvin, V. L., & Reed, K. L. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj140 · Cited by 507
Oberdörster, E., Zhu, S., Blickley, T. M., McClellan‐Green, P. D., & Haasch, M. L. (2005) · Carbon · doi:10.1016/j.carbon.2005.11.008 · Cited by 506
Human skin penetration of silver nanoparticles through intact and damaged skin
Filon, F. L., D’Agostin, F., Crosera, M., Adami, G., Renzi, N., Bovenzi, M., & Maina, G. (2008) · Toxicology · doi:10.1016/j.tox.2008.09.025 · Cited by 495
Skin as a route of exposure and sensitization in chronic beryllium disease.
Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., Depree, K. M., & Adkins, E. J. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5999 · Cited by 483
Cross, S. E., Innes, B., Roberts, M. S., Tsuzuki, T., Robertson, T. A., & Mccormick, P. (2007) · Skin Pharmacology and Physiology · doi:10.1159/000098701 · Cited by 481
Tsuji, J. S., Maynard, A., Howard, P. C., James, J. T., Lam, C., Warheit, D. B., & Santamaria, A. B. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi339 · Cited by 474
Monteiller, C., Tran, L., MacNee, W., Faux, S., Jones, A., Miller, B., & Donaldson, K. (2007) · Occupational and Environmental Medicine · doi:10.1136/oem.2005.024802 · Cited by 473
Duffin, R., Tran, L., Brown, D. M., Stone, V., & Donaldson, K. (2007) · Inhalation Toxicology · doi:10.1080/08958370701479323 · Cited by 469
Penetration of Metallic Nanoparticles in Human Full-Thickness Skin
Baroli, B. M., Ennas, M. G., Loffredo, F., Isola, M., Pinna, R., & López-Quintela, M. A. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700733 · Cited by 464
Inhaled carbon nanotubes reach the subpleural tissue in mice
Ryman-Rasmussen, J. P., Cesta, M. F., Brody, A. R., Shipley-Phillips, J. K., Everitt, J. I., Tewksbury, E. W., Moss, O. R., Wong, B. A., Dodd, D. E., Andersen, M. E., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.305 · Cited by 459
Air Pollution and Cardiovascular Injury
Simkhovich, B. Z., Kleinman, M. T., & Kloner, R. A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.029 · Cited by 443
Potential Health Impact of Nanoparticles
Xia, T., Li, N., & Nel, A. E. (2009) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.031308.100155 · Cited by 432
Zhu, S., Oberdörster, E., & Haasch, M. L. (2006) · Marine Environmental Research · doi:10.1016/j.marenvres.2006.04.059 · Cited by 417
Warheit, D. B. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfm279 · Cited by 417
Cytotoxicity of single-wall carbon nanotubes on human fibroblasts
Tian, F., Cui, D., Schwarz, H., Estrada, G. G., & Kobayashi, H. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.03.008 · Cited by 414
Reviewing the Environmental and Human Health Knowledge Base of Carbon Nanotubes
Helland, A., Wick, P., Köhler, A. R., Schmid, K., & Som, C. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9652 · Cited by 413
Self-citationInduction of cytotoxicity by photoexcited TiO2 particles.
Cai, R., Kubota, Y., Shuin, T., Sakai, H., Hashimoto, K., & Fujishima, A. (1992) · PubMed · Cited by 410
Testing Metal‐Oxide Nanomaterials for Human Safety
Landsiedel, R., Ma‐Hock, L., Kröll, A., Hahn, D., Schnekenburger, J., Wiench, K., & Wohlleben, W. (2010) · Advanced Materials · doi:10.1002/adma.200902658 · Cited by 394
Kreyling, W. G., Semmler‐Behnke, M., Seitz, J., Scymczak, W., Wenk, A., Mayer, P., Takenaka, S., & Oberdörster, G. (2009) · Inhalation Toxicology · doi:10.1080/08958370902942517 · Cited by 385
Nanoparticles and the Brain: Cause for Concern?
Oberdörster, G., Elder, A. C. P., & Rinderknecht, A. L. (2009) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2009.gr02 · Cited by 377
Yamago, S., Tokuyama, H., Nakamura, E., Kikuchi, K., Kananishi, S., Sueki, K., Nakahara, H., Enomoto, S., & Fumitoshi, A. M. B. E. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90219-8 · Cited by 374
Nanosized zinc oxide particles induce neural stem cell apoptosis
Deng, X., Luan, Q., Chen, W., Wang, Y., Wu, M., Zhang, H., & Jiao, Z. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/11/115101 · Cited by 371
Evaluation of nanoparticle immunotoxicity
Dobrovolskaia, M. A., Germolec, D. R., & Weaver, J. L. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.175 · Cited by 368
Air Pollution, Ultrafine and Nanoparticle Toxicology: Cellular and Molecular Interactions
Stone, V., Johnston, H. J., & Clift, M. J. D. (2007) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2007.909005 · Cited by 367
Ryman-Rasmussen, J. P., Riviere, J. E., & Monteiro-Riviere, N. A. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700508 · Cited by 357
Aquatic environmental nanoparticles
Wigginton, N. S., Haus, K. L., & Hochella, M. F. (2007) · Journal of Environmental Monitoring · doi:10.1039/b712709j · Cited by 355
Sato, Y., Yokoyama, A., Shibata, K., Akimoto, Y., Ogino, S.-I., Nodasaka, Y., Kohgo, T., Tamura, K., Akasaka, T., Uo, M., et al. (2005) · Molecular BioSystems · doi:10.1039/b502429c · Cited by 351
Wiesner, M. R., Lowry, G. V., Jones, K., Hochella, M. F., Giulio, R. T. D., Casman, E. A., & Bernhardt, E. S. (2009) · Environmental Science & Technology · doi:10.1021/es803621k · Cited by 350
Challenges for assessing carbon nanomaterial toxicity to the skin
Monteiro-Riviere, N. A., & Inman, A. O. (2005) · Carbon · doi:10.1016/j.carbon.2005.11.004 · Cited by 344
Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes
Murray, A. R., Kisin, E. R., Leonard, S. S., Young, S., Kommineni, C., Kagan, V. E., Castranova, V., & Shvedova, A. A. (2008) · Toxicology · doi:10.1016/j.tox.2008.12.023 · Cited by 344
Simon-Deckers, A., Gouget, B., Mayne–L'Hermite, M., Herlin‐Boime, N., Reynaud, C., & Carrière, M. (2008) · Toxicology · doi:10.1016/j.tox.2008.09.007 · Cited by 340
Gulson, B. L., McCall, M. J., Korsch, M. J., Gomez, L., Casey, P. S., Oytam, Y., Taylor, A., McCulloch, M. T., Trotter, J., Kinsley, L. P. J., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq243 · Cited by 329
Rouse, J. G., Yang, J., Ryman-Rasmussen, J. P., Barron, A. R., & Monteiro-Riviere, N. A. (2006) · Nano Letters · doi:10.1021/nl062464m · Cited by 317
Casey, A., Herzog, E., Davoren, M., Lyng, F. M., Byrne, H. J., & Chambers, G. (2007) · Carbon · doi:10.1016/j.carbon.2007.03.033 · Cited by 301
Nanoparticle dermal absorption and toxicity: a review of the literature
Crosera, M., Bovenzi, M., Maina, G., Adami, G., Zanette, C., Florio, C., & Filon Larese, F. (2009) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-009-0458-x · Cited by 297
Warheit, D. B., Webb, T. R., Colvin, V. L., Reed, K. L., & Sayes, C. M. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl128 · Cited by 294
Acute pulmonary effects of ultrafine particles in rats and mice.
Oberdörster, G., Finkelstein, J. N., Johnston, C. J., Gelein, R. M., Cox, C., Baggs, R. B., & Elder, A. C. P. (2000) · PubMed · Cited by 287
Wichmann, H. ‐. (2007) · Inhalation Toxicology · doi:10.1080/08958370701498075 · Cited by 286
The effects of particle size and surface coating on the cytotoxicity of nickel ferrite
Yin, H. F., Too, H., & Chow, G. M. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.036 · Cited by 285
Sayes, C. M., Marchione, A. A., Reed, K. L., & Warheit, D. B. (2007) · Nano Letters · doi:10.1021/nl0710710 · Cited by 282
Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells
Gerloff, K., Albrecht, C., Boots, A. W., Förster, I., & Schins, R. P. F. (2009) · Nanotoxicology · doi:10.3109/17435390903276933 · Cited by 264
Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes
ZHANG, L., YU, W., COLVIN, V, & MONTEIRORIVIERE, N. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.12.022 · Cited by 247
Sager, T. M., & Castranova, V. (2009) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-6-15 · Cited by 230
Concurrent Aggregation and Deposition of TiO2 Nanoparticles in a Sandy Porous Media
Solovitch, N., Labille, J., Rose, J., Chaurand, P., Borschneck, D., Wiesner, M. R., & Bottero, J. (2010) · Environmental Science & Technology · doi:10.1021/es1000819 · Cited by 228
TOXICOKINETICS AND EFFECTS OF FIBROUS AND NONFIBROUS PARTICLES
Oberdörster, G. (2002) · Inhalation Toxicology · doi:10.1080/089583701753338622 · Cited by 221
Rothen‐Rutishauser, B., Blank, F., Mühlfeld, C., & Gehr, P. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.8.1075 · Cited by 214
The reliability and limits of the MTT reduction assay for carbon nanotubes–cell interaction
Belyanskaya, L. L., Manser, P., Spohn, P., Bruinink, A., & Wick, P. (2007) · Carbon · doi:10.1016/j.carbon.2007.08.010 · Cited by 199
Self-citationPan, Z., Lee, W., Slutsky, L., Clark, R. A. F., Pernodet, N., & Rafailovich, M. H. (2009) · Small · doi:10.1002/smll.200800798 · Cited by 197
Müller, L. L., Riediker, M., Wick, P., Mohr, M., Gehr, P., & Rothen‐Rutishauser, B. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0161.focus · Cited by 197
Self-citationZhang, L. W., Zeng, L., Barron, A. R., & Monteiro-Riviere, N. A. (2007) · International Journal of Toxicology · doi:10.1080/10915810701225133 · Cited by 192
Wottrich, R., Diabaté, S., & Krug, H. F. (2004) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00300 · Cited by 190
Self-citationAn introduction to the short-term toxicology of respirable industrial fibres
Donaldson, K., & Tran, C. L. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.011 · Cited by 189
Zhang, Q., Kusaka, Y., Zhu, X., Sato, K., Mo, Y., Kluz, T., & Donaldson, K. (2003) · Journal of Occupational Health · doi:10.1539/joh.45.23 · Cited by 183
Assessment of Quantum Dot Penetration into Intact, Tape-Stripped, Abraded and Flexed Rat Skin
Zhang, L. W., & Monteiro-Riviere, N. A. (2008) · Skin Pharmacology and Physiology · doi:10.1159/000131080 · Cited by 176
Bennat, & Müller‐Goymann (2000) · International Journal of Cosmetic Science · doi:10.1046/j.1467-2494.2000.00009.x · Cited by 176
Lumineszierende Kohlenstoff‐Nanopunkte: Nanolichtquellen mit Zukunft
Baker, S. N., & Baker, G. A. (2010) · Angewandte Chemie · doi:10.1002/ange.200906623 · Cited by 175
Serpone, N., Salinaro, A., Emeline, A. V., Horikoshi, S., Hidaka, H., & Zhao, J. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b206338g · Cited by 160
Kuhlbusch, T. A. J., Neumann, S., & Fissan, H. J. (2004) · Journal of Occupational and Environmental Hygiene · doi:10.1080/15459620490502242 · Cited by 147
Kiss, B., Bı́ró, T., Czifra, G., Tóth, B. I., Kertész, Z., Szikszai, Z., Kiss, Á. Z., Juhász, I., Zouboulis, C. C., & Hunyadi, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00683.x · Cited by 143
Spohn, P., Hirsch, C., Hasler, F., Bruinink, A., Krug, H. F., & Wick, P. (2008) · Environmental Pollution · doi:10.1016/j.envpol.2008.08.013 · Cited by 139
Self-citationHealth impact of nanomaterials?
Hoet, P., Nemmar, A., & Nemery, B. (2004) · Nature Biotechnology · doi:10.1038/nbt0104-19 · Cited by 138
Biological Behavior of Hat-Stacked Carbon Nanofibers in the Subcutaneous Tissue in Rats
Yokoyama, A., Sato, Y., Nodasaka, Y., Yamamoto, S., Ḱawasaki, T., Shindoh, M., Kohgo, T., Akasaka, T., Uo, M., Watari, F., et al. (2004) · Nano Letters · doi:10.1021/nl0484752 · Cited by 134
A Murine Scavenger Receptor MARCO Recognizes Polystyrene Nanoparticles
Kanno, S., Furuyama, A., & Hirano, S. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm050 · Cited by 131
Körting, H. C., Zienicke, H., Sch�fer-Korting, M., & Braun‐Falco, O. (1990) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315408 · Cited by 123
Netzlaff, F., Kaca, M., Bock, U., Haltner-Ukomadu, E., Meiers, P., Lehr, C., & Schaefer, U. (2007) · European journal of pharmaceutics and biopharmaceutics · doi:10.1016/j.ejpb.2006.08.012 · Cited by 115
Passage of particles through the wall of the gastrointestinal tract
Volkheimer, G. (1974) · Environmental Health Perspectives · doi:10.1289/ehp.749215 · Cited by 112
Stoeger, T., Takenaka, S., Frankenberger, B., Baerbel, R., Karg, E. W., Maier, K., Schulz, H., & Schmid, O. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11370 · Cited by 109
Nanoparticulate Vanadium Oxide Potentiated Vanadium Toxicity in Human Lung Cells
Wörle‐Knirsch, J. M., Kern, K., Schleh, C., Adelhelm, C., Feldmann, C., & Krug, H. F. (2006) · Environmental Science & Technology · doi:10.1021/es061140x · Cited by 108
Self-citationNanoparticles in Drug Delivery and Environmental Exposure: Same Size, Same Risks?
Borm, P. J. A., & Müller-Schulte, D. (2006) · Nanomedicine · doi:10.2217/17435889.1.2.235 · Cited by 107
Risk Assessment of Engineered Nanomaterials: A Survey of Industrial Approaches
Helland, A., Scheringer, M., Siegrist, M., Kastenholz, H., Wiek, A., & Scholz, R. W. (2007) · Environmental Science & Technology · doi:10.1021/es062807i · Cited by 101
Xia, X. R., Monteiro-Riviere, N. A., & Riviere, J. E. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.09.011 · Cited by 99
The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
Schleh, C., Mühlfeld, C., Pulskamp, K., Schmiedl, A., Nassimi, M., Lauenstein, H. D., Braun, A. C., Krug, N., Erpenbeck, V. J., & Hohlfeld, J. M. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-90 · Cited by 98
Mühlen, C. V. Z., von Elverfeldt, D., Bassler, N., Neudorfer, I., Steitz, B., Petri‐Fink, A., Hofmann, H., Bode, C., & Peter, K. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.048 · Cited by 97
Nanopartikuläre Funktionsmaterialien
Goesmann, H., & Feldmann, C. (2010) · Angewandte Chemie · doi:10.1002/ange.200903053 · Cited by 96
Advances in zinc finger engineering
Choo, Y., & Isalan, M. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00107-x · Cited by 95
Behra, R., & Krug, H. F. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.113 · Cited by 92
Self-citationPeptide‐Grafted Nanodiamonds: Preparation, Cytotoxicity and Uptake in Cells
Vial, S., Mansuy, C., Sagan, S., Irinopoulou, T., Burlina, F., Boudou, J. P., Chassaing, G., & Lavielle, S. (2008) · ChemBioChem · doi:10.1002/cbic.200800247 · Cited by 90
Brune, H., Wyrwa, D. W., Viola Vogel, B., Simon, U., Schmid, G., Rathgeber, W., Mayor, M., Krug, H. F., Janich, P., Hofmann, H., et al. (2006) · Springer eBooks · doi:10.1007/3-540-32820-3 · Cited by 78
Self-citationNanomedizin – Herausforderung und Perspektiven
Riehemann, K., Schneider, S. W., Luger, T. A., Godin, B., Mauro Ferrari, B., & Fuchs, H. (2009) · Angewandte Chemie · doi:10.1002/ange.200802585 · Cited by 74
Interactions of aluminum nanoparticles with human epidermal keratinocytes
Monteiro-Riviere, N. A., Oldenburg, S. J., & Inman, A. O. (2009) · Journal of Applied Toxicology · doi:10.1002/jat.1494 · Cited by 72
Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor
Nagayama, S., Ogawara, K., Minato, K., Fukuoka, Y., Takakura, Y., Hashida, M., Higaki, K., & Kimura, T. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.025 · Cited by 68
Carcinogenicity of inhaled nanoparticles
Roller, M. (2009) · Inhalation Toxicology · doi:10.1080/08958370902942541 · Cited by 67
Kovochich, M., Espinasse, B. P., Auffan, M., Hotze, E. M., Wessel, L. E., Xia, T., Nel, A. E., & Wiesner, M. R. (2009) · Environmental Science & Technology · doi:10.1021/es900990d · Cited by 62
Food for thought … on alternative methods for nanoparticle safety testing
Härtung, T. (2010) · ALTEX · doi:10.14573/altex.2010.2.87 · Cited by 61
Warheit, D. B., Reed, K. L., & Sayes, C. M. (2009) · Inhalation Toxicology · doi:10.1080/08958370902942640 · Cited by 60
Irreversible Pulmonary Changes Induced in Rat Lung by Dust Overload
Bellmann, B., Muhle, H., Creutzenberg, O., & Mermelstein, R. (1992) · Environmental Health Perspectives · doi:10.1289/ehp.9297189 · Cited by 56
Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage
Aoshima, H., Saitoh, Y., Ito, S., Yamana, S., & Miwa, N. (2009) · The Journal of Toxicological Sciences · doi:10.2131/jts.34.555 · Cited by 53
Zinc Induces Apoptosis That Can Be Suppressed by Lanthanum in C6 Rat Glioma Cells
Haase, H., Wätjen, W., & Beyersmann, D. (2001) · Biological Chemistry · doi:10.1515/bc.2001.153 · Cited by 48
Kato, S., Aoshima, H., Saitoh, Y., & Miwa, N. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00396.x · Cited by 48
Buerki‐Thurnherr, T., Su, D. S., Diener, L., Weinberg, G., Manser, P., Pfänder, N., Arrigo, R., Schuster, M. E., Wick, P., & Krug, H. F. (2009) · Nanotoxicology · doi:10.3109/17435390903276958 · Cited by 45
Self-citationUltrafine 239PuO2 Aerosol Generation, Characterization and Short-term Inhalation Study in the Rat
Kanapilly, G. M., & Diel, J. H. (1980) · Health Physics · doi:10.1097/00004032-198009000-00009 · Cited by 39
Passage of Particles through the Wall of of the Gastrointestinal Tract
Volkheimer, G. (1974) · Environmental Health Perspectives · doi:10.2307/3428287 · Cited by 39
Mallampati, R., Patlolla, R. R., Agarwal, S., Babu, R. J., Hayden, P. J., Klausner, M., & Singh, M. S. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.08.019 · Cited by 37
Orthmann, A., Zeisig, R., Koklič, T., Šentjurc, M., Wiesner, B., Lemm, M., & Fichtner, I. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22001 · Cited by 26
Dose-response relationship of fibrous dusts in intraperitoneal studies.
Roller, M., Pott, F., Kamino, K., Althoff, G.-H., & Bellmann, B. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51253 · Cited by 22
Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes
Zhang, L. W., & Monteiro-Riviere, N. A. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.11.007 · Cited by 19
Nanopartikel: Gesundheitsrisiko, Therapiechance?
Krug, H. F. (2003) · Nachrichten aus der Chemie · doi:10.1002/nadc.20030511207 · Cited by 7
Self-citationGulledge, W. P. (2007) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2007.06.009 · Cited by 5
Dose-Response Relationship of Fibrous Dusts in Intraperitoneal Studies
Roller, M., POTT, F., Kamino, K., Althoff, G.-H., & Bellmann, B. (1997) · Environmental Health Perspectives · doi:10.2307/3433542 · Cited by 5
Research works printed but not linked: 8
- Krug H. F., 2007, Arbeitsmed. Sozialmed. Umweltmed., 42, 4
- Brune H., 2006, Nanotechnology—Assessment and Perspectives
- Lippert H., 2000, Lehrbuch Anatomie, 5th ed., 803
- 10.1289/ehp.0901200 · DOI
- Brüske‐Hohlfeld I., 2008, Nanotechnology: Environmental Aspects, Vol. 2, 267
- N. A. Monteiro‐Riviere J. E. Riviere inProceedings—Nanotechnology and the Environment: Applications and Implications Progress Review Workshop III U.S. Environmental Protection Agency Office of Research and Development Washington 2005.
- Cai R., 1992, Cancer Res., 52, 2346
- Krug H. F., 2006, Nanomaterials—Toxicity, Health and Environmental Issues, Vol. 5, 153
Cited by
Sorted by citations
Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems
Ferrari, A. C., Bonaccorso, F., Fal’ko, V. I., Novoselov, K. S., Roche, S., Bøggild, P., Borini, S., Koppens, F. H. L., Palermo, V., Pugno, N. M., et al. (2014) · Nanoscale · doi:10.1039/c4nr01600a · Cited by 3,065
Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal
Chernousova, S., & Epple, M. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201205923 · Cited by 2,297
Titanium Dioxide Nanoparticles in Food and Personal Care Products
Weir, A., Westerhoff, P. K., Fabricius, L., Hristovski, K. D., & Goetz, N. V. (2012) · Environmental Science & Technology · doi:10.1021/es204168d · Cited by 2,166
von Moos, N., Burkhardt-Holm, P., & Köhler, A. (2012) · Environmental Science & Technology · doi:10.1021/es302332w · Cited by 1,697
Sapsford, K. E., Algar, W. R., Berti, L., Gemmill, K. B., Casey, B. J., Oh, E., Stewart, M. H., & Medintz, I. L. (2013) · Chemical Reviews · doi:10.1021/cr300143v · Cited by 1,470
Metadata
- Authors
- Krug, H. F., & Wick, P.
- Affiliations
- Empa (CH)
- Corresponding author
- Krug, Harald F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-01-11
- Volume
- 50
- Issue
- 6
- Pages
- 1260-1278
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2169703093
- Cited by
- 556
- References
- 166
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 28 · 2023: 23 · 2022: 25 · 2021: 31 · 2020: 32 · 2019: 30 · 2018: 41 · 2017: 40 · 2016: 30 · 2015: 45 · 2014: 62 · 2013: 70 · 2012: 51
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- nanotoxicology, nanomaterials, nanomaterial-cell interactions, health risks, research reliability, methodological quality, data quality improvement, interdisciplinary research
- MeSH terms
- Blood-Brain Barrier, Humans, Lung, Skin, Nanostructures
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review