The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Nanotoxicology: An Interdisciplinary Challenge
Abstract
The increasing consumption of products containing nanomaterials that can be currently observed and forecasts of new developments and applications fan the fear of individuals and organizations regarding new risks to health. Considering experiences gained from previous technology developments, such fears are not completely unfounded. But are they really justified? And is it justified, moreover, to speak of “nanotoxicology” as a new discipline? This Review seeks to cast light on the phenomena that may occur as nanoobjects interact with cells, tissues, and organisms. Furthermore, we will demonstrate that the many data made available on the biological effects of nanomaterials do not always come from studies that can be considered reliable. We will point out the aspect of reliability with specific examples from the literature and will not address specific (nano)materials. In particular, inadequate methods will be described together with recommendations how to avoid this in the future, thereby contributing to a sustainable improvement of the available data.
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“As studies with engineered nanoparticles have suggested and investigations of plastic particles are starting to indicate, toxicity induced by micro-nano particles is not only dose-dependent but also related to particle physicochemical characteristics and their effect on cellular interactions and uptake (81, 82).”
From Rapid single-particle chemical imaging of nanoplastics by SRS microscopy (2024) · cites this paper as [81]
Citations
Cites
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Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems
Ferrari, A. C., Bonaccorso, F., Fal’ko, V. I., Novoselov, K. S., Roche, S., Bøggild, P., Borini, S., Koppens, F. H. L., Palermo, V., Pugno, N. M., et al. (2014) · Nanoscale · doi:10.1039/c4nr01600a · Cited by 3,065
Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal
Chernousova, S., & Epple, M. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201205923 · Cited by 2,297
Titanium Dioxide Nanoparticles in Food and Personal Care Products
Weir, A., Westerhoff, P. K., Fabricius, L., Hristovski, K. D., & Goetz, N. V. (2012) · Environmental Science & Technology · doi:10.1021/es204168d · Cited by 2,166
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Sapsford, K. E., Algar, W. R., Berti, L., Gemmill, K. B., Casey, B. J., Oh, E., Stewart, M. H., & Medintz, I. L. (2013) · Chemical Reviews · doi:10.1021/cr300143v · Cited by 1,470
Metadata
- Authors
- Krug, H. F., & Wick, P.
- Affiliations
- Empa (CH)
- Corresponding author
- Krug, Harald F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-01-11
- Volume
- 50
- Issue
- 6
- Pages
- 1260-1278
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2169703093
- Cited by
- 556
- References
- 166
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 28 · 2023: 23 · 2022: 25 · 2021: 31 · 2020: 32 · 2019: 30 · 2018: 41 · 2017: 40 · 2016: 30 · 2015: 45 · 2014: 62 · 2013: 70 · 2012: 51
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- nanotoxicology, nanomaterials, nanomaterial-cell interactions, health risks, research reliability, methodological quality, data quality improvement, interdisciplinary research
- MeSH terms
- Blood-Brain Barrier, Humans, Lung, Skin, Nanostructures
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