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Nanotoxicology: An Interdisciplinary Challenge

Krug, Harald F., Wick, Peter·2011·Angewandte Chemie International Edition

DOI 10.1002/anie.201001037

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Abstract

The increasing consumption of products containing nanomaterials that can be currently observed and forecasts of new developments and applications fan the fear of individuals and organizations regarding new risks to health. Considering experiences gained from previous technology developments, such fears are not completely unfounded. But are they really justified? And is it justified, moreover, to speak of “nanotoxicology” as a new discipline? This Review seeks to cast light on the phenomena that may occur as nanoobjects interact with cells, tissues, and organisms. Furthermore, we will demonstrate that the many data made available on the biological effects of nanomaterials do not always come from studies that can be considered reliable. We will point out the aspect of reliability with specific examples from the literature and will not address specific (nano)materials. In particular, inadequate methods will be described together with recommendations how to avoid this in the future, thereby contributing to a sustainable improvement of the available data.

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Authors: Krug, H. F., & Wick, P.
Affiliations: Empa (CH)
Corresponding author: Krug, Harald F.
ORCID: Krug, Harald F.
Wick, Peter
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2011-01-11
Volume: 50
Issue: 6
Pages: 1260-1278
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.201001037
OpenAlex: W2169703093
Cited by: 556
References: 166
Citations by year: 2026: 5 · 2025: 12 · 2024: 28 · 2023: 23 · 2022: 25 · 2021: 31 · 2020: 32 · 2019: 30 · 2018: 41 · 2017: 40 · 2016: 30 · 2015: 45 · 2014: 62 · 2013: 70 · 2012: 51
FWCI: 3.29
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Physical Sciences › Materials Science › General Materials Science › Nanotechnology research and applications
Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
Keywords: nanotoxicology, nanomaterials, nanomaterial-cell interactions, health risks, research reliability, methodological quality, data quality improvement, interdisciplinary research
MeSH terms: Blood-Brain Barrier, Humans, Lung, Skin, Nanostructures

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Nanotoxicology: An Interdisciplinary Challenge

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