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Staudinger Ligation as a Method for Bioconjugation
Abstract
In 1919 the German chemist Hermann Staudinger was the first to describe the reaction between an azide and a phosphine. It was not until recently, however, that Bertozzi and co‐workers recognized the potential of this reaction as a method for bioconjugation and transformed it into the so‐called Staudinger ligation. The bio‐orthogonal character of both the azide and the phosphine functions has resulted in the Staudinger ligation finding numerous applications in various complex biological systems. For example, the Staudinger ligation has been utilized to label glycans, lipids, DNA, and proteins. Moreover, the Staudinger ligation has been used as a synthetic method to construct glycopeptides, microarrays, and functional biopolymers. In the emerging field of bio‐orthogonal ligation strategies, the Staudinger ligation has set a high standard to which most of the new techniques are often compared. This Review summarizes recent developments and new applications of the Staudinger ligation.
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Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Sletten, E. M., & Bertozzi, C. R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900942 · Cited by 3,165
Adding New Chemistries to the Genetic Code
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Heparan sulphate proteoglycans fine-tune mammalian physiology
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A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
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Trafficking and signaling by fatty-acylated and prenylated proteins
Resh, M. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio834 · Cited by 521
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Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
Lang, K., & Chin, J. W. (2014) · Chemical Reviews · doi:10.1021/cr400355w · Cited by 1,035
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
McKay, C. S., & Finn, M. G. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.002 · Cited by 768
Bioconjugation with Strained Alkenes and Alkynes
Debets, M. F., van Berkel, S. S., Dommerholt, J., Dirks, A. (. J., Rutjes, F. P. J. T., & van Delft, F. L. (2011) · Accounts of Chemical Research · doi:10.1021/ar200059z · Cited by 564
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Metadata
- Authors
- van Berkel, S. S., van Eldijk, M. B., & van Hest, J. C. M.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-09-02
- Volume
- 50
- Issue
- 38
- Pages
- 8806-8827
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2118730911
- Cited by
- 283
- References
- 6
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- closed
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