The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Optochemical Genetics
Abstract
Transmembrane receptors allow a cell to communicate with its environment in response to a variety of input signals. These can be changes in the concentration of ligands (e.g. hormones or neurotransmitters), temperature, pressure (e.g. acoustic waves or touch), transmembrane potential, or light intensity. Many important receptors have now been characterized in atomic detail and our understanding of their functional properties has markedly increased in recent years. As a consequence, these sophisticated molecular machines can be reprogrammed to respond to unnatural input signals. In this Review, we show how voltage‐gated and ligand‐gated ion channels can be endowed with synthetic photoswitches, and how the resulting artificial photoreceptors can be used to optically control neurons with exceptional temporal and spatial precision. They work well in animals and might find applications in the restoration of vision and the optical control of other sensations. The combination of synthetic photoswitches and receptor proteins contributes to the field of optogenetics and adds a new functional dimension to chemical genetics. As such, we propose to call it “optochemical genetics”.
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The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal Structure
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Self-citationLiGluR restores visual responses in rodent models of inherited blindness
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Knie, C., Utecht, M., Zhao, F., Kulla, H., Kovalenko, S., Brouwer, A. M., Saalfrank, P., Hecht, S., & Bléger, D. (2014) · Chemistry – A European Journal · doi:10.1002/chem.201404649 · Cited by 438
Silencing Neurons: Tools, Applications, and Experimental Constraints
Wiegert, J. S., Mahn, M., Prigge, M., Printz, Y., & Yizhar, O. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.050 · Cited by 312
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Metadata
- Authors
- Fehrentz, T., Schönberger, M., & Trauner, D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-11-23
- Volume
- 50
- Issue
- 51
- Pages
- 12156-12182
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W4211175101
- Cited by
- 377
- References
- 9
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- closed
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