The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Stimuli‐Responsive Theragrippers for Chemomechanical Controlled Release
Open accessAbstract
We report on a therapeutic approach using thermo‐responsive multi‐fingered drug eluting devices. These therapeutic grippers referred to as theragrippers are shaped using photolithographic patterning and are composed of rigid poly(propylene fumarate) segments and stimuli‐responsive poly(N‐isopropylacrylamide‐co‐acrylic acid) hinges. They close above 32 °C allowing them to spontaneously grip onto tissue when introduced from a cold state into the body. Due to porosity in the grippers, theragrippers could also be loaded with fluorescent dyes and commercial drugs such as mesalamine and doxorubicin, which eluted from the grippers for up to seven days with first order release kinetics. In an in vitro model, theragrippers enhanced delivery of doxorubicin as compared to a control patch. We also released theragrippers into a live pig and visualized release of dye in the stomach. The design of such tissue gripping drug delivery devices offers an effective strategy for sustained release of drugs with immediate applicability in the gastrointestinal tract.
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Cites
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Self-citationAn Integrated Microrobotic Platform for On‐Demand, Targeted Therapeutic Interventions
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Cited by
Momeni, F., M.Mehdi Hassani.N, S., Liu, X., & Ni, J. (2017) · Materials & Design · doi:10.1016/j.matdes.2017.02.068 · Cited by 1,165
Multimaterial 4D Printing with Tailorable Shape Memory Polymers
Ge, Q., Sakhaei, A. H., Lee, H., Dunn, C. K., Fang, N. X., & Dunn, M. L. (2016) · Scientific Reports · doi:10.1038/srep31110 · Cited by 1,160
Magnetically Driven Micro and Nanorobots
Zhou, H., Mayorga-Martinez, C. C., Pané, S., Zhang, L., & Pumera, M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01234 · Cited by 889
Stimuli-responsive hydrogels in drug delivery and tissue engineering
Sood, N., Bhardwaj, A., Mehta, S., & Mehta, A. (2016) · Drug Delivery · doi:10.3109/10717544.2014.940091 · Cited by 426
Materials for Smart Soft Actuator Systems
Apsite, I., Salehi, S., & Ionov, L. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00453 · Cited by 357
Metadata
- Authors
- Malachowski, K., Breger, J., Kwag, H. R., Wang, M. O., Fisher, J. P., Selaru, F. M., & Gracias, D. H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-03-14
- Volume
- 53
- Issue
- 31
- Pages
- 8045-8049
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2172212677
- Cited by
- 257
- References
- 38
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Malachowski, K., Breger, J., Kwag, H. R., Wang, M. O., Fisher, J. P., Selaru, F. M., & Gracias, D. H. (2014). Stimuli‐Responsive Theragrippers for Chemomechanical Controlled Release. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201311047
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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