The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Potent Oxidant Anticancer Activity of Organoiridium Catalysts
Open accessAbstract
Platinum complexes are the most widely used anticancer drugs; however, new generations of agents are needed. The organoiridium(III) complex [(η 5‐Cp xbiph)Ir(phpy)(Cl)] (1‐Cl), which contains π‐bonded biphenyltetramethylcyclopentadienyl (Cp xbiph) and C^N‐chelated phenylpyridine (phpy) ligands, undergoes rapid hydrolysis of the chlorido ligand. In contrast, the pyridine complex [(η 5‐Cp xbiph)Ir(phpy)(py)]+(1‐py) aquates slowly, and is more potent (in nanomolar amounts) than both 1‐Cl and cisplatin towards a wide range of cancer cells. The pyridine ligand protects 1‐py from rapid reaction with intracellular glutathione. The high potency of 1‐py correlates with its ability to increase substantially the level of reactive oxygen species (ROS) in cancer cells. The unprecedented ability of these iridium complexes to generate H 2 O 2 by catalytic hydride transfer from the coenzyme NADH to oxygen is demonstrated. Such organoiridium complexes are promising as a new generation of anticancer drugs for effective oxidant therapy.
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Cites
CRC Handbook of Chemistry and Physics
(2014) · doi:10.1201/b17118 · Cited by 57,706
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Organoiridium Complexes: Anticancer Agents and Catalysts
Liu, Z., & Sadler, P. J. (2014) · Accounts of Chemical Research · doi:10.1021/ar400266c · Cited by 573
Self-citationAdvances in the design of organometallic anticancer complexes
Zhang, P., & Sadler, P. J. (2017) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2017.03.038 · Cited by 369
Self-citationMetallodrugs in cancer nanomedicine
Peña, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H. W., Metselaar, J. M., Kiessling, F., Pallares, R. M., Wuttke, S., & Lammers, T. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00468a · Cited by 259
Bringing inorganic chemistry to life with inspiration from R. J. P. Williams
Hill, H. A. O., & Sadler, P. J. (2016) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-016-1333-3 · Cited by 17
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Metadata
- Authors
- Liu, Z., Romero‐Canelón, I., Qamar, B., Hearn, J. M., Habtemariam, A., Barry, N. P. E., Pizarro, A. M., Clarkson, G. J., & Sadler, P. J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-03-11
- Volume
- 53
- Issue
- 15
- Pages
- 3941-3946
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2125282969
- Cited by
- 345
- References
- 4
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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