The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Live‐Cell Stimulated Raman Scattering Imaging of Alkyne‐Tagged Biomolecules
Abstract
Alkynes can be metabolically incorporated into biomolecules including nucleic acids, proteins, lipids, and glycans. In addition to the clickable chemical reactivity, alkynes possess a unique Raman scattering within the Raman‐silent region of a cell. Coupling this spectroscopic signature with Raman microscopy yields a new imaging modality beyond fluorescence and label‐free microscopies. The bioorthogonal Raman imaging of various biomolecules tagged with an alkyne by a state‐of‐the‐art Raman imaging technique, stimulated Raman scattering (SRS) microscopy, is reported. This imaging method affords non‐invasiveness, high sensitivity, and molecular specificity and therefore should find broad applications in live‐cell imaging.
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Cites
Trafficking and signaling by fatty-acylated and prenylated proteins
Resh, M. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio834 · Cited by 521
Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
Yamakoshi, H., Dodo, K., Palonpon, A., Ando, J., Fujita, K., Kawata, S., & Sodeoka, M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308529n · Cited by 461
Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
Yamakoshi, H., Dodo, K., Okada, M., Ando, J., Palonpon, A., Fujita, K., Kawata, S., & Sodeoka, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108404p · Cited by 356
Label‐Free Live‐Cell Imaging of Nucleic Acids Using Stimulated Raman Scattering Microscopy
Zhang, X., Roeffaers, M. B. J., Basu, S., Daniele, J. R., Fu, D., Freudiger, C. W., Holtom, G. R., & Xie, X. S. (2012) · ChemPhysChem · doi:10.1002/cphc.201100890 · Cited by 171
Cited by
Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine
Cheng, J.-X., & Xie, X. S. (2015) · Science · doi:10.1126/science.aaa8870 · Cited by 874
Super-multiplex vibrational imaging
Wei, L., Chen, Z., Shi, L., Long, R., Anzalone, A. V., Zhang, L., Hu, F., Yuste, R., Cornish, V. W., & Min, W. (2017) · Nature · doi:10.1038/nature22051 · Cited by 514
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Biological imaging of chemical bonds by stimulated Raman scattering microscopy
Hu, F., Shi, L., & Min, W. (2019) · Nature Methods · doi:10.1038/s41592-019-0538-0 · Cited by 392
Hu, F., Lamprecht, M. R., Wei, L., Morrison, B., & Min, W. (2016) · Scientific Reports · doi:10.1038/srep39660 · Cited by 367
Metadata
- Authors
- Hong, S., Chen, T., Zhu, Y., Li, A., Huang, Y., & Chen, X.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-04-17
- Volume
- 53
- Issue
- 23
- Pages
- 5827-5831
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2172124640
- Cited by
- 203
- References
- 4
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- closed
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