The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Control of Three‐Dimensional Cell Adhesion by the Chirality of Nanofibers in Hydrogels
Abstract
In the three‐dimensional (3D) extracellular matrix (ECM), the influence of nanofiber chirality on cell behavior is very important; the helical nanofibrous structure is closely related to the relevant biological events. Herein, we describe the use of the two enantiomers of a 1,4‐benzenedicarboxamide phenylalanine derivative as supramolecular gelators to investigate the influence of the chirality of nanofibers on cell adhesion and proliferation in three dimensions. It was found that left‐handed helical nanofibers can increase cell adhesion and proliferation, whereas right‐handed nanofibers have the opposite effect. These effects are ascribed to the mediation of the stereospecific interaction between chiral nanofibers and fibronectin. The results stress the crucial role of the chirality of nanofibers on cell‐adhesion and cell‐proliferation behavior in 3D environments.
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Cites
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Cited by
Supramolecular Chirality in Self-Assembled Systems
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Cellulose Biomaterials for Tissue Engineering
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Self-citationChiral Recognition of Lipid Bilayer Membranes by Supramolecular Assemblies of Peptide Amphiphiles
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Metadata
- Authors
- Liu, G., Zhang, D., & Feng, C.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-06-10
- Volume
- 53
- Issue
- 30
- Pages
- 7789-7793
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2011126577
- Cited by
- 253
- References
- 43
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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