The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Expanded Genetic Alphabet
Open accessAbstract
All biological information, since the last common ancestor of all life on Earth, has been encoded by a genetic alphabet consisting of only four nucleotides that form two base pairs. Long‐standing efforts to develop two synthetic nucleotides that form a third, unnatural base pair (UBP) have recently yielded three promising candidates, one based on alternative hydrogen bonding, and two based on hydrophobic and packing forces. All three of these UBPs are replicated and transcribed with remarkable efficiency and fidelity, and the latter two thus demonstrate that hydrogen bonding is not unique in its ability to underlie the storage and retrieval of genetic information. This Review highlights these recent developments as well as the applications enabled by the UBPs, including the expansion of the evolution process to include new functionality and the creation of semi‐synthetic life that stores increased information.
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Accurate whole human genome sequencing using reversible terminator chemistry
Bentley, D. R., Balasubramanian, S., Swerdlow, H. P., Smith, G. P., Milton, J., Brown, C. G., Hall, K. P., Evers, D. J., Barnes, C. L., Bignell, H. R., et al. (2008) · Nature · doi:10.1038/nature07517 · Cited by 3,684
Adding New Chemistries to the Genetic Code
Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725
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FIDELITY MECHANISMS IN DNA REPLICATION
Echols, H., & Goodman, M. F. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.002401 · Cited by 712
Comparison between DNA melting thermodynamics and DNA polymerase fidelity.
Petruska, J., Goodman, M. F., Boosalis, M. S., Sowers, L. C., Cheong, C., & Tinoco, I. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6252 · Cited by 316
Cited by
Seeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875
The Current State of Peptide Drug Discovery: Back to the Future?
Henninot, A., Collins, J. C., & Nuss, J. M. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00318 · Cited by 1,113
Recent progress in non-native nucleic acid modifications
McKenzie, L. K., El-Khoury, R., Thorpe, J. D., Damha, M. J., & Hollenstein, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01430c · Cited by 300
How DNA polymerases catalyse replication and repair with contrasting fidelity
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Metadata
- Authors
- Malyshev, D. A., & Romesberg, F. E.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-08-25
- Volume
- 54
- Issue
- 41
- Pages
- 11930-11944
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2113078079
- Cited by
- 200
- References
- 5
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- green
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