How DNA polymerases catalyse replication and repair with contrasting fidelity
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The G*-C* occupation probability calculated within an open quantum system approach is several orders of magnitude greater than the observed rate (10^-8 per base pair) of spontaneous mutations through copying errors.
“We find it to be several orders of magnitude greater than the observed rate (10 -8 per base pair 16 ) of spontaneous mutations through, for example, copying errors, suggesting that tautomerisation may well play an important role in point mutations.”
From An open quantum systems approach to proton tunnelling in DNA (2022) · cites this paper as [16]
The model predicts a rate of tautomerisation much higher than the overall rate of spontaneous mutations (~10^-8).
“our model predicts a rate of tautomerisation much higher than the overall rate of spontaneous mutations (~10 -8 ) 16”
From An open quantum systems approach to proton tunnelling in DNA (2022) · cites this paper as [16]
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An open quantum systems approach to proton tunnelling in DNA
Slocombe, L., Sacchi, M., & Al-Khalili, J. (2022) · Communications Physics · doi:10.1038/s42005-022-00881-8 · Cited by 122 · see citing works
- Authors
- Wu, W.-J., Yang, W., & Tsai, M.-D.
- Affiliations
- Institute of Biological Chemistry, Academia Sinica (TW)
- National Institutes of Health (US)
- National Taiwan University (TW)
- Corresponding author
- Tsai, Ming-Daw
- Venue
- Nature Reviews Chemistry
- Published
- 2017-09-06
- Volume
- 1
- Issue
- 9
- ISSN
- 2397-3358 (ISSN-L)
- OpenAlex
- W2750714005
- Cited by
- 76
- References
- 12
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 4 · 2019: 10 · 2018: 8 · 2017: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Chemistry (publishedVersion)
- Funders
- Francis Crick Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- DNA polymerase, DNA replication, DNA repair, replication fidelity, non-Watson-Crick base pairing, genetic mutations, polymerase structure, polymerase mechanism
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