FIDELITY MECHANISMS IN DNA REPLICATION
Abstract
BASE INSERTION SELECTIVITY BY DNA POL YMERASES . The Base 1''lSertion Pathway . Structural Aspects to Base Selection by DNA Polymerases . Polymerase Insertion Errors . Fidelity Assays and Major Conclusions . Error Avoidance in Base Insertion----General Conclusions ..... .
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The geometries of A:T and G:C base pairs are remarkably similar to each other but differ from mismatched base pairs.
“The geometries of A⅐T and G⅐C base pairs are remarkably similar to each other but differ from mismatched base pairs (15,19,24,31,32).”
From DNA Replication Fidelity (2004) · cites this paper as [31]
Nucleotide selectivity largely depends on geometric selection for the shape and size of correct Watson-Crick base pairs.
“This tight fit is consistent with a concept that emerged about 25 years ago (reviewed in Refs.15 and 31) that nucleotide selectivity largely depends on geometric selection for the shape and size of correct Watson-Crick base pairs.”
From DNA Replication Fidelity (2004) · cites this paper as [31]
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BackgroundMethod
- Authors
- Echols, H., & Goodman, M. F.
- Affiliations
- University of California, Berkeley (US)
- ORCID
- Goodman, Myron F.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1991-06
- Volume
- 60
- Issue
- 1
- Pages
- 477-511
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2138476183
- Cited by
- 712
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 18
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Francis Crick Institute
- Vlaamse regering
- National Institutes of Health (5r01ca041655-10, 5r01gm042554-13)
- National Cancer Institute (CA 41655)
- National Institute of General Medical Sciences (GM 42554, GM 21422)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- DNA replication fidelity, DNA polymerase, insertion errors, polymerase structure, error prevention
- MeSH terms
- DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Escherichia coli, Kinetics, Mutation, SOS Response, Genetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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