The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Biocatalytic Feedback‐Driven Temporal Programming of Self‐Regulating Peptide Hydrogels
Abstract
Switchable self‐assemblies respond to external stimuli with a transition between near‐equilibrium states. Although being a key to present‐day advanced materials, these systems respond rather passively, and do not display autonomous dynamics. For autonomous behavior, approaches must be found to orchestrate the time domain of self‐assemblies, which would lead to new generations of dynamic and self‐regulating materials. Herein, we demonstrate catalytic control of the time domain of pH‐responsive peptide hydrogelators in a closed system. We program transient acidic pH states by combining a fast acidic activator with the slow, enzymatic, feedback‐driven generation of a base (dormant deactivator). This transient state can be programmed over orders of magnitude in time. It is coupled to dipeptides to create autonomously self‐regulating, dynamic gels with programmed lifetimes, which are used for fluidic guidance, burst release, and self‐erasing rapid prototyping.
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Cited by
Ashkenasy, G., Hermans, T. M., Otto, S., & Taylor, A. F. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00117g · Cited by 595
Dissipative out-of-equilibrium assembly of man-made supramolecular materials
van Rossum, S. A. P., Tena-Solsona, M., van Esch, J. H., Eelkema, R., & Boekhoven, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00246g · Cited by 561
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
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Metadata
- Authors
- Heuser, T., Weyandt, E., & Walther, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-08-06
- Volume
- 54
- Issue
- 45
- Pages
- 13258-13262
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2168466384
- Cited by
- 266
- References
- 40
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
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