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Single‐Molecule Sensors: Challenges and Opportunities for Quantitative Analysis
Open accessAbstract
Measurement science has been converging to smaller and smaller samples, such that it is now possible to detect single molecules. This Review focuses on the next generation of analytical tools that combine single‐molecule detection with the ability to measure many single molecules simultaneously and/or process larger and more complex samples. Such single‐molecule sensors constitute a new type of quantitative analytical tool, as they perform analysis by molecular counting and thus potentially capture the heterogeneity of the sample. This Review outlines the advantages and potential of these new, quantitative single‐molecule sensors, the measurement challenges in making single‐molecule devices suitable for analysis, the inspiration biology provides for overcoming these challenges, and some of the solutions currently being explored.
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Cites
Direct observation of kinesin stepping by optical trapping interferometry
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Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics
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Cited by
Single-Molecule Plasmon Sensing: Current Status and Future Prospects
Taylor, A. B., & Zijlstra, P. (2017) · ACS Sensors · doi:10.1021/acssensors.7b00382 · Cited by 366
Single Biomolecule Imaging by Electrochemiluminescence
Liu, Y., Zhang, H., Li, B., Liu, J., Jiang, D., Liu, B., & Sojic, N. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c06673 · Cited by 303
Nanoparticles for super-resolution microscopy and single-molecule tracking
Jin, D., Xi, P., Wang, B., Zhang, L., Enderlein, J., & van Oijen, A. M. (2018) · Nature Methods · doi:10.1038/s41592-018-0012-4 · Cited by 283
Single-molecule protein sensing in a nanopore: a tutorial
Varongchayakul, N., Song, J., Meller, A., & Grinstaff, M. W. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00106e · Cited by 282
Single-molecule detection with a millimetre-sized transistor
Macchia, E., Manoli, K., Holzer, B., Di Franco, C., Ghittorelli, M., Torricelli, F., Alberga, D., Mangiatordi, G. F., Palazzo, G., Scamarcio, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05235-z · Cited by 253
Metadata
- Authors
- Gooding, J. J., & Gaus, K.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-07-22
- Volume
- 55
- Issue
- 38
- Pages
- 11354-11366
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2490860910
- Cited by
- 340
- References
- 5
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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