SlipChip
Open accessAbstract
The SlipChip is a microfluidic device designed to perform multiplexed microfluidic reactions without pumps or valves. The device has two plates in close contact. The bottom plate contains wells preloaded with many reagents; in this paper plates with 48 reagents were used. These wells are covered by the top plate that acts as a lid for the wells with reagents. The device also has a fluidic path, composed of ducts in the bottom plate and wells in the top plate, which is connected only when the top and bottom plate are aligned in a specific configuration. Sample can be added into the fluidic path, filling both wells and ducts. Then, the top plate is "slipped", or moved, relative to the bottom plate so the complementary patterns of wells in both plates overlap, exposing the sample-containing wells of the top plate to the reagent-containing wells of the bottom plate, and enabling diffusion and reactions. Between the two plates, a lubricating layer of fluorocarbon was used to facilitate relative motion of the plates. This paper implements this approach on a nanoliter scale using devices fabricated in glass. Stability of preloaded solutions, control of loading, and lack of cross-contamination were tested using fluorescent dyes. Functionality of the device was illustrated via crystallization of a model membrane protein. Fabrication of this device is simple and does not require a bonding step. This device requires no pumps or valves and is applicable to resource-poor settings. Overall, this device should be valuable for multiplexed applications that require exposing one sample to many reagents in small volumes. One may think of the SlipChip as an easy-to-use analogue of a preloaded multi-well plate, or a preloaded liquid-phase microarray.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SlipChip is especially appropriate for integrated DNA-based data storage because all microdroplets can be moved simultaneously by sliding, so no valves, pumps, or tubes are required.
“As a microfluidic device for handling a large array of microdroplets, SlipChip is a platform that is especially appropriate for the development of an integrated DNA-based data storage system. All the microdroplets can be moved simultaneously on a SlipChip by simply sliding the device, so no valves, pumps, or tubes are required (54–56).”
From Electrochemical DNA synthesis and sequencing on a single electrode with scalability for integrated data storage (2021) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)
Duffy, D. C., McDonald, J. C., Schueller, O. J. A., & Whitesides, G. M. (1998) · Analytical Chemistry · doi:10.1021/ac980656z · Cited by 5,301 · see citing works
Chaotic Mixer for Microchannels
Stroock, A. D., Dertinger, S. K. W., Ajdari, A., Mezić, I., Stone, H. A., & Whitesides, G. M. (2002) · Science · doi:10.1126/science.1066238 · Cited by 3,435 · see citing works
Formation of dispersions using “flow focusing” in microchannels
Anna, S. L., Bontoux, N., & Stone, H. A. (2003) · Applied Physics Letters · doi:10.1063/1.1537519 · Cited by 2,319 · see citing works
Microfluidic Large-Scale Integration
Thorsen, T., Maerkl, S. J., & Quake, S. R. (2002) · Science · doi:10.1126/science.1076996 · Cited by 2,223 · see citing works
Reactions in Droplets in Microfluidic Channels
Song, H., Chen, D. L., & Ismagilov, R. F. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601554 · Cited by 1,844 · see citing works
Self-citationMartinez, A. W., Phillips, S. T., Carrilho, E., Thomas, S. W., Sindi, H., & Whitesides, G. M. (2008) · Analytical Chemistry · doi:10.1021/ac800112r · Cited by 1,445 · see citing works
Three-dimensional microfluidic devices fabricated in layered paper and tape
Martinez, A. W., Phillips, S. T., & Whitesides, G. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810903105 · Cited by 1,247 · see citing works
PDMS absorption of small molecules and consequences in microfluidic applications
Toepke, M. W., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b612140c · Cited by 1,193 · see citing works
A Microfluidic System for Controlling Reaction Networks in Time
Song, H., Tice, J. D., & Ismagilov, R. F. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390203 · Cited by 1,083 · see citing works
Self-citationGeneration of Gradients Having Complex Shapes Using Microfluidic Networks
Dertinger, S. K. W., Chiu, D. T., Jeon, N. L., & Whitesides, G. M. (2001) · Analytical Chemistry · doi:10.1021/ac001132d · Cited by 842 · see citing works
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693 · see citing works
Self-citationBiocompatible surfactants for water-in-fluorocarbon emulsions
Holtze, C., Rowat, A. C., Agresti, J. J., Hutchison, J. B., Angile, F. E., Schmitz, C., Köster, S., Duan, H., Humphry, K. J., Scanga, R. A., et al. (2008) · Lab on a Chip · doi:10.1039/b806706f · Cited by 667 · see citing works
Fan, R., Vermesh, O., Srivastava, A., Yen, B. K. H., Qin, L., Ahmad, H. M. N., Kwong, G. A., Liu, C.-C., Gould, J., Hood, L., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt.1507 · Cited by 539 · see citing works
Chiu, D. T., Jeon, N. L., Huang, S., Kane, R. S., Wargo, C. J., Choi, I. S., Ingber, D. E., & Whitesides, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040562297 · Cited by 526 · see citing works
Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
Lee, C.-C., Sui, G., Elizarov, A. M., Shu, C. J., Shin, Y. S., Dooley, A. N., Huang, J., Daridon, A., Wyatt, P., Stout, D., et al. (2005) · Science · doi:10.1126/science.1118919 · Cited by 508 · see citing works
Microfabricated Centrifugal Microfluidic Systems: Characterization and Multiple Enzymatic Assays
Duffy, D. C., Gillis, H. L., Lin, J., Sheppard, N. F., & Kellogg, G. J. (1999) · Analytical Chemistry · doi:10.1021/ac990682c · Cited by 478 · see citing works
Boedicker, J. Q., Li, L., Kline, T. R., & Ismagilov, R. F. (2008) · Lab on a Chip · doi:10.1039/b804911d · Cited by 436 · see citing works
Self-citationSong, H., Bringer, M. R., Tice, J. D., Gerdts, C. J., & Ismagilov, R. F. (2003) · Applied Physics Letters · doi:10.1063/1.1630378 · Cited by 432 · see citing works
Self-citationYin, H., Killeen, K., Brennen, R. A., Sobek, D., Werlich, M., & van de Goor, T. (2004) · Analytical Chemistry · doi:10.1021/ac049068d · Cited by 362 · see citing works
Moon, H., Wheeler, A. R., Garrell, R. L., Loo, J. A., & Kim, C. (2006) · Lab on a Chip · doi:10.1039/b601954d · Cited by 297 · see citing works
An Integrated Approach to a Portable and Low‐Cost Immunoassay for Resource‐Poor Settings
Sia, S. K., Linder, V., Parviz, B. A., Siegel, A. C., & Whitesides, G. M. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200353016 · Cited by 293 · see citing works
Emrich, C. A., Tian, H., Medintz, I. L., & Mathies, R. A. (2002) · Analytical Chemistry · doi:10.1021/ac020236g · Cited by 285 · see citing works
Roach, L. S., Song, H., & Ismagilov, R. F. (2004) · Analytical Chemistry · doi:10.1021/ac049061w · Cited by 277 · see citing works
Self-citationLi, L., Mustafi, D., Fu, Q., Tereshko, V. A., Chen, D. L., Tice, J. D., & Ismagilov, R. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607502103 · Cited by 243 · see citing works
Self-citationKhademhosseini, A., Yeh, J., Eng, G. M., Karp, J. M., Kaji, H., Borenstein, J. T., Farokhzad, O. C., & Langer, R. (2005) · Lab on a Chip · doi:10.1039/b508096g · Cited by 238 · see citing works
Zheng, B., & Ismagilov, R. F. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462857 · Cited by 233 · see citing works
Self-citationChen, D. L., Du, W., Liu, Y., Liu, W., Kuznetsov, A., Mendez, F., Philipson, L. H., & Ismagilov, R. F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807916105 · Cited by 226 · see citing works
Self-citationHatakeyama, T., Chen, D. L., & Ismagilov, R. F. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057720w · Cited by 186 · see citing works
Self-citationAdamson, D. N., Mustafi, D., Zhang, J. X. J., Zheng, B., & Ismagilov, R. F. (2006) · Lab on a Chip · doi:10.1039/b604993a · Cited by 161 · see citing works
Self-citationSong, H., Li, H., Munson, M. S., Ha, T. G. V., & Ismagilov, R. F. (2006) · Analytical Chemistry · doi:10.1021/ac0601718 · Cited by 144 · see citing works
Self-citationParallel Nanoliter Microfluidic Analysis System
Andersson, P., Jesson, G., Kylberg, G., Ekstrand, G., & Thorsén, G. (2007) · Analytical Chemistry · doi:10.1021/ac061692y · Cited by 108 · see citing works
Choi, C. J., & Cunningham, B. T. (2007) · Lab on a Chip · doi:10.1039/b618584c · Cited by 98 · see citing works
Chen, D. L., & Ismagilov, R. F. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.04.004 · Cited by 96 · see citing works
Self-citationMultichannel PCR-CE Microdevice for Genetic Analysis
Liu, C. N., Toriello, N. M., & Mathies, R. A. (2006) · Analytical Chemistry · doi:10.1021/ac060335k · Cited by 89 · see citing works
Li, L., Boedicker, J. Q., & Ismagilov, R. F. (2007) · Analytical Chemistry · doi:10.1021/ac062179n · Cited by 88 · see citing works
Self-citationOldenburg, K. R., Zhang, J.-H., Chen, T., Maffia, A. M., Blom, K. F., Combs, A. P., & Chung, T. D. Y. (1998) · SLAS DISCOVERY · doi:10.1177/108705719800300108 · Cited by 74 · see citing works
Zhou, X., Lau, L., Lam, W. W. L., Au, S. W. N., & Zheng, B. (2007) · Analytical Chemistry · doi:10.1021/ac070306p · Cited by 73 · see citing works
A label‐free protein microfluidic array for parallel immunoassays
Wang, Z.-H., Meng, Y., Ying, P., Cai, Q., & Jin, G. (2006) · Electrophoresis · doi:10.1002/elps.200500956 · Cited by 58 · see citing works
Kreutz, J. E., Li, L., Roach, L. S., Hatakeyama, T., & Ismagilov, R. F. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808697e · Cited by 54 · see citing works
Self-citationDNA methylation analysis on a droplet-in-oil PCR array
Zhang, Y., Bailey, V. J., Puleo, C., Easwaran, H., Griffiths, E. A., Herman, J. G., Baylin, S. B., & Wang, T. (2009) · Lab on a Chip · doi:10.1039/b821780g · Cited by 45 · see citing works
Desmet, G., & Baron, G. V. (2000) · Analytical Chemistry · doi:10.1021/ac991254+ · Cited by 44 · see citing works
Meier, M., Kennedy‐Darling, J., Choi, S. H., Norstrom, E. M., Sisodia, S. S., & Ismagilov, R. F. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805225 · Cited by 42 · see citing works
Self-citationA chip-to-chip nanoliter microfluidic dispenser
Wang, J., Zhou, Y., Qiu, H., Huang, H., Sun, C., Xi, J., & Huang, Y. (2009) · Lab on a Chip · doi:10.1039/b901635j · Cited by 37 · see citing works
He, Q., Chen, S., Su, Y., Fang, Q., & Chen, H. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.08.040 · Cited by 32 · see citing works
On-chip liquid storage and dispensing for lab-on-a-chip applications
Bodén, R., Lehto, M., Margell, J., Hjort, K., & Schweitz, J. (2008) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/18/7/075036 · Cited by 29 · see citing works
Moerman, R., Knoll, J., Apetrei, C., van den Doel, L. R., & van Dedem, G. W. K. (2004) · Analytical Chemistry · doi:10.1021/ac0400515 · Cited by 27 · see citing works
Moerman, R., & van Dedem, G. W. K. (2003) · Analytical Chemistry · doi:10.1021/ac020432n · Cited by 12 · see citing works
Channel-free shear driven circular liquid chromatography
Cai, Y., Janasek, D., West, J. J., Franzke, J., & Manz, A. (2008) · Lab on a Chip · doi:10.1039/b809420a · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [38]Tokeshi M Kitamori T Trojanowicz M ch. 6 Flow Analysis in Microfluidic Devices Wiley VCH 149 166
Cited by
Sorted by citations
Emerging Droplet Microfluidics
Shang, L., Cheng, Y., & Zhao, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00848 · Cited by 1,583 · see citing works
Quan, P.-L., Sauzade, M., & Brouzes, E. (2018) · Sensors · doi:10.3390/s18041271 · Cited by 664 · see citing works
Microfluidic Devices for Bioapplications
Yeo, L. Y., Chang, H., Chan, P. P. Y., & Friend, J. R. (2010) · Small · doi:10.1002/smll.201000946 · Cited by 621 · see citing works
Innovations to culturing the uncultured microbial majority
Lewis, W. H., Tahon, G., Geesink, P., Sousa, D. Z., & Ettema, T. J. G. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00458-8 · Cited by 614 · see citing works
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application
Gong, M. M., & Sinton, D. A. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00024 · Cited by 573 · see citing works
Droplet Microfluidics—A Tool for Single‐Cell Analysis
Joensson, H. N., & Svahn, H. A. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201200460 · Cited by 553 · see citing works
Analytical detection techniques for droplet microfluidics—A review
Zhu, Y., & Fang, Q. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.04.064 · Cited by 365 · see citing works
The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors
Tu, J., Torrente-Rodríguez, R. M., Wang, M., & Gao, W. F. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906713 · Cited by 359 · see citing works
Microfluidics for medical diagnostics and biosensors
Rivet, C. A., Lee, H., Hirsch, A., Hamilton, S. K., & Lu, H. (2010) · Chemical Engineering Science · doi:10.1016/j.ces.2010.08.015 · Cited by 359 · see citing works
Electrochemistry, biosensors and microfluidics: a convergence of fields
Rackus, D. G., Shamsi, M. H., & Wheeler, A. R. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00369a · Cited by 357 · see citing works
Single‐Molecule Sensors: Challenges and Opportunities for Quantitative Analysis
Gooding, J. J., & Gaus, K. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201600495 · Cited by 342 · see citing works
Microvalves and Micropumps for BioMEMS
Au, A. K., Lai, H., Utela, B. R., & Folch, A. (2011) · Micromachines · doi:10.3390/mi2020179 · Cited by 333 · see citing works
Challenges and Solutions in Developing Ultrasensitive Biosensors
Wu, Y., Tilley, R. D., & Gooding, J. J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09397 · Cited by 307 · see citing works
Zhu, Z., Guan, Z., Jia, S., Lei, Z., Lin, S., Zhang, H., Ma, Y., Tian, Z., & Yang, C. J. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201405995 · Cited by 304 · see citing works
Controlled droplet microfluidic systems for multistep chemical and biological assays
Kamiński, T. S., & Garstecki, P. (2017) · Chemical Society Reviews · doi:10.1039/c5cs00717h · Cited by 301 · see citing works
Shen, F., Du, W., Kreutz, J. E., Fok, A., & Ismagilov, R. F. (2010) · Lab on a Chip · doi:10.1039/c004521g · Cited by 295 · see citing works
Self-citationPolymerase chain reaction in microfluidic devices
Ahrberg, C. D., Manz, A., & Chung, B. G. (2016) · Lab on a Chip · doi:10.1039/c6lc00984k · Cited by 282 · see citing works
Droplet Microarrays: From Surface Patterning to High‐Throughput Applications
Feng, W., Ueda, E., & Levkin, P. A. (2018) · Advanced Materials · doi:10.1002/adma.201706111 · Cited by 246 · see citing works
Shen, F., Davydova, E. K., Du, W., Kreutz, J. E., Piepenburg, O., & Ismagilov, R. F. (2011) · Analytical Chemistry · doi:10.1021/ac200247e · Cited by 240 · see citing works
Self-citationLAMP-on-a-chip: Revising microfluidic platforms for loop-mediated DNA amplification
Zhang, H., Xu, Y., Fohlerová, Z., Chang, H., Iliescu, C., & Neužil, P. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.01.015 · Cited by 232 · see citing works
Shen, F., Sun, B., Kreutz, J. E., Davydova, E. K., Du, W., Reddy, P. L., Joseph, L. J., & Ismagilov, R. F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2060116 · Cited by 231 · see citing works
Self-citationMultiplexed volumetric bar-chart chip for point-of-care diagnostics
Song, Y., Zhang, Y., Bernard, P. E., Reuben, J. M., Ueno, N. T., Arlinghaus, R. B., Zu, Y., & Qin, L. (2012) · Nature Communications · doi:10.1038/ncomms2292 · Cited by 220 · see citing works
Protein Crystallization Using Microfluidic Technologies Based on Valves, Droplets, and SlipChip
Li, L., & Ismagilov, R. F. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.050708.133630 · Cited by 209 · see citing works
Self-citationPopova, A. A., Schillo, S., Demir, K., Ueda, E., Nesterov‐Mueller, A., & Levkin, P. A. (2015) · Advanced Materials · doi:10.1002/adma.201502115 · Cited by 209 · see citing works
Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells
Cole, R. H., Tang, S., Siltanen, C. A., Shahi, P., Zhang, J. Q., Poust, S. K., Gartner, Z. J., & Abate, A. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704020114 · Cited by 204 · see citing works
Yelleswarapu, V. R., Buser, J. R., Haber, M., Baron, J. A., Inapuri, E., & Issadore, D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814110116 · Cited by 185 · see citing works
Hollow-Channel Paper Analytical Devices
Renault, C., Li, X., Fosdick, S. E., & Crooks, R. M. (2013) · Analytical Chemistry · doi:10.1021/ac401786h · Cited by 178 · see citing works
Detection of Hepatitis B Virus DNA with a Paper Electrochemical Sensor
Li, X., Scida, K., & Crooks, R. M. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02210 · Cited by 174 · see citing works
Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices
Park, J., Han, D. H., & Park, J. (2020) · Lab on a Chip · doi:10.1039/d0lc00047g · Cited by 175 · see citing works
Aralekallu, S., Boddula, R., & Singh, V. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111517 · Cited by 176 · see citing works
Distance-based microfluidic quantitative detection methods for point-of-care testing
Tian, T., Li, J., Song, Y., Zhou, L., Zhu, Z., & Yang, C. J. (2016) · Lab on a Chip · doi:10.1039/c5lc01562f · Cited by 172 · see citing works
The Potential Impact of Droplet Microfluidics in Biology
Schneider, T., Kreutz, J. E., & Chiu, D. T. (2013) · Analytical Chemistry · doi:10.1021/ac400257c · Cited by 166 · see citing works
Cardoso, B. D., Castanheira, E. M. S., Lanceros-Méndez, S., & Cardoso, V. F. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202936 · Cited by 168 · see citing works
Safavieh, M., Kanakasabapathy, M. K., Tarlan, F., Ahmed, M. U., Zourob, M. M., Asghar, W., & Shafiee, H. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00449 · Cited by 162 · see citing works
Semisynthetic sensor proteins enable metabolic assays at the point of care
Yu, Q., Xue, L., Hiblot, J., Griss, R., Fabritz, S., Roux, C., Binz, P., Haas, D., Okun, J. G., & Johnsson, K. (2018) · Science · doi:10.1126/science.aat7992 · Cited by 159 · see citing works
Ma, L., Kim, J.-W., Hatzenpichler, R., Karymov, M. A., Hubert, N., Hanan, I. M., Chang, E. B., & Ismagilov, R. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404753111 · Cited by 158 · see citing works
Self-citationHu, J., Cui, X., Gong, Y. M., Xu, X., Gao, B., Wen, T., Lu, T. J., & Xu, F. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.02.008 · Cited by 154 · see citing works
Sliding-strip microfluidic device enables ELISA on paper
Verma, M. S., Tsaloglou, M., Sisley, T. A., Christodouleas, D. C., Chen, A. C., Milette, J., & Whitesides, G. M. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.07.034 · Cited by 152 · see citing works
Kreutz, J. E., Munson, T., Huynh, T., Shen, F., Du, W., & Ismagilov, R. F. (2011) · Analytical Chemistry · doi:10.1021/ac201658s · Cited by 148 · see citing works
Self-citationReview: Microbial analysis in dielectrophoretic microfluidic systems
Fernandez, R. E., Rohani, A., Farmehini, V., & Swami, N. S. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.02.024 · Cited by 146 · see citing works
Watterson, W. J., Tanyeri, M., Watson, A. R., Cham, C. M., Shan, Y., Chang, E. B., Eren, A. M., & Tay, S. (2020) · eLife · doi:10.7554/elife.56998 · Cited by 146 · see citing works
Microfluidics Using Spatially Defined Arrays of Droplets in One, Two, and Three Dimensions
Pompano, R. R., Liu, W., Du, W., & Ismagilov, R. F. (2011) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.012809.102303 · Cited by 140 · see citing works
Self-citationProgress in the development and integration of fluid flow control tools in paper microfluidics
Fu, E. S., & Downs, C. (2017) · Lab on a Chip · doi:10.1039/c6lc01451h · Cited by 141 · see citing works
Microfluidic static droplet arrays with tuneable gradients in material composition
Sun, M. Z., Bithi, S. S., & Vanapalli, S. A. (2011) · Lab on a Chip · doi:10.1039/c1lc20709a · Cited by 136 · see citing works
Digital polymerase chain reaction technology – recent advances and future perspectives
Sreejith, K. R., Ooi, C. H., Jin, J., Dao, D. V., & Nguyen, N. (2018) · Lab on a Chip · doi:10.1039/c8lc00990b · Cited by 137 · see citing works
Integrated microfluidic systems with sample preparation and nucleic acid amplification
Yin, J., Suo, Y., Zou, Z., Sun, J., Zhang, S., Wang, B., Xu, Y., Darland, D. C., Zhao, J. X., & Mu, Y. (2019) · Lab on a Chip · doi:10.1039/c9lc00389d · Cited by 128 · see citing works
Kreutz, J. E., Shukhaev, A., Du, W., Druskin, S., Daugulis, O., & Ismagilov, R. F. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909853x · Cited by 126 · see citing works
Self-citationMicrofluidic platforms: a mainstream technology for the preparation of crystals
Puigmartí‐Luis, J. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60372e · Cited by 126 · see citing works
Chan, H. N., Shu, Y., Xiong, B., Chen, Y., Chen, Y., Tian, Q., Michael, S. A., Shen, B., & Wu, H. (2015) · ACS Sensors · doi:10.1021/acssensors.5b00100 · Cited by 126 · see citing works
Rodríguez-Manzano, J., Karymov, M. A., Begolo, S., Selck, D. A., Zhukov, D. V., Jue, E., & Ismagilov, R. F. (2016) · ACS Nano · doi:10.1021/acsnano.5b07338 · Cited by 125 · see citing works
Self-citationWei, X., Zhou, W., Sanjay, S. T., Zhang, J., Jin, Q., Xu, F., Domínguez, D. C., & Li, X. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b02055 · Cited by 119 · see citing works
LAMP-Based Point-of-Care Biosensors for Rapid Pathogen Detection
Das, D., Lin, C., & Chuang, H.-S. (2022) · Biosensors · doi:10.3390/bios12121068 · Cited by 119 · see citing works
Nanoliter Multiplex PCR Arrays on a SlipChip
Shen, F., Du, W., Davydova, E. K., Karymov, M. A., Pandey, J., & Ismagilov, R. F. (2010) · Analytical Chemistry · doi:10.1021/ac1007249 · Cited by 115 · see citing works
Self-citationLoop-mediated isothermal amplification-based microfluidic chip for pathogen detection
Shang, Y., Sun, J., Ye, Y., Zhang, J., Zhang, Y., & Sun, X. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1518897 · Cited by 114 · see citing works
Zhu, Y., Zhang, Y., Cai, L., & Fang, Q. (2013) · Analytical Chemistry · doi:10.1021/ac4006414 · Cited by 110 · see citing works
Synchronized Synthesis of Peptide‐Based Macrocycles by Digital Microfluidics
Jebrail, M. J., Ng, A. H. C., Rai, V., Hili, R., Yudin, A. K., & Wheeler, A. R. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201001604 · Cited by 109 · see citing works
Chemistry-Driven Approaches for Ultrasensitive Nucleic Acid Detection
Smith, S. J., Nemr, C. R., & Kelley, S. O. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b10850 · Cited by 108 · see citing works
Begolo, S., Zhukov, D. V., Selck, D. A., Li, L., & Ismagilov, R. F. (2014) · Lab on a Chip · doi:10.1039/c4lc00910j · Cited by 107 · see citing works
Self-citationSelf-Digitization of Sample Volumes
Cohen, D. E., Schneider, T., Wang, M. Y., & Chiu, D. T. (2010) · Analytical Chemistry · doi:10.1021/ac100713u · Cited by 106 · see citing works
Ghazal, A., Lafleur, J., Mortensen, K., Kutter, J. P., Arleth, L., & Jensen, G. V. (2016) · Lab on a Chip · doi:10.1039/c6lc00888g · Cited by 104 · see citing works
Recent advances in microfluidics for drug screening
Sun, J., Warden, A. R., & Ding, X. (2019) · Biomicrofluidics · doi:10.1063/1.5121200 · Cited by 104 · see citing works
SlipChip for Immunoassays in Nanoliter Volumes
Liu, W., Chen, D. L., Du, W., Nichols, K. P., & Ismagilov, R. F. (2010) · Analytical Chemistry · doi:10.1021/ac100044c · Cited by 102 · see citing works
Self-citationVincent, M. E., Liu, W., Haney, E. B., & Ismagilov, R. F. (2010) · Chemical Society Reviews · doi:10.1039/b917851a · Cited by 102 · see citing works
Self-citationPopova, A. A., Demir, K., Hartanto, G., Schmitt, E., & Levkin, P. A. (2016) · RSC Advances · doi:10.1039/c6ra06011k · Cited by 101 · see citing works
Paper-Based SlipPAD for High-Throughput Chemical Sensing
Liu, H., Li, X., & Crooks, R. M. (2013) · Analytical Chemistry · doi:10.1021/ac4008623 · Cited by 101 · see citing works
Mauk, M. G., Song, J., Liu, C., & Bau, H. H. (2018) · Biosensors · doi:10.3390/bios8010017 · Cited by 97 · see citing works
Advances of Microfluidics in Biomedical Engineering
Zhong, Q., Ding, H., Gao, B., He, Z., & Gu, Z. (2019) · Advanced Materials Technologies · doi:10.1002/admt.201800663 · Cited by 95 · see citing works
Sun, B., Shen, F., McCalla, S. E., Kreutz, J. E., Karymov, M. A., & Ismagilov, R. F. (2013) · Analytical Chemistry · doi:10.1021/ac3037206 · Cited by 95 · see citing works
Self-citationLi, L., Du, W., & Ismagilov, R. F. (2009) · Journal of the American Chemical Society · doi:10.1021/ja908558m · Cited by 95 · see citing works
Self-citationSimple, Sensitive, and Quantitative Electrochemical Detection Method for Paper Analytical Devices
Scida, K., Cunningham, J. C., Renault, C., Richards, I., & Crooks, R. M. (2014) · Analytical Chemistry · doi:10.1021/ac501004a · Cited by 93 · see citing works
Mixing Enhancement in Serpentine Micromixers with a Non-Rectangular Cross-Section
Clark, J., Kaufman, M., & Fodor, P. S. (2018) · Micromachines · doi:10.3390/mi9030107 · Cited by 93 · see citing works
Reagents in microfluidics: an ‘in’ and ‘out’ challenge
Hitzbleck, M., & Delamarche, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60118h · Cited by 92 · see citing works
Nanoliter-Scale Protein Crystallization and Screening with a Microfluidic Droplet Robot
Zhu, Y., Zhu, L., Guo, R., Cui, H.-J., Ye, S., & Fang, Q. (2014) · Scientific Reports · doi:10.1038/srep05046 · Cited by 90 · see citing works
Yu, Z., Lyu, W., Yu, M., Wang, Q., Qu, H., Ismagilov, R. F., Han, X., Lai, D., & Shen, F. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112107 · Cited by 89 · see citing works
Self-citationA Multistage Volumetric Bar Chart Chip for Visualized Quantification of DNA
Song, Y., Wang, Y., & Qin, L. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4085397 · Cited by 87 · see citing works
Recent developments towards portable point-of-care diagnostic devices for pathogen detection
Roy, S., Arshad, F., Eissa, S., Safavieh, M., Alattas, S. G., Ahmed, M. U., & Zourob, M. M. (2021) · Sensors & Diagnostics · doi:10.1039/d1sd00017a · Cited by 84 · see citing works
Slaney, T. R., Nie, J., Hershey, N. D., Thwar, P. K., Linderman, J. J., Burns, M. A., & Kennedy, R. T. (2011) · Analytical Chemistry · doi:10.1021/ac2003938 · Cited by 82 · see citing works
On-demand microfluidic droplet manipulation using hydrophobic ferrofluid as a continuous-phase
Zhang, K., Liang, Q., Ai, X., Hu, P., Wang, Y., & Luo, G. (2011) · Lab on a Chip · doi:10.1039/c0lc00484g · Cited by 82 · see citing works
Passive micropumping in microfluidics for point-of-care testing
Xu, L., Wang, A., Li, X., & Oh, K. W. (2020) · Biomicrofluidics · doi:10.1063/5.0002169 · Cited by 81 · see citing works
Cai, D., Xiao, M., Xu, P., Xu, Y., & Du, W. (2014) · Lab on a Chip · doi:10.1039/c4lc00669k · Cited by 80 · see citing works
Self-citationSelck, D. A., Karymov, M. A., Sun, B., & Ismagilov, R. F. (2013) · Analytical Chemistry · doi:10.1021/ac4030413 · Cited by 80 · see citing works
Self-citationXu, C., Ma, B., Gao, Z., Dong, X., Zhao, C., & Liu, H. (2021) · Science Advances · doi:10.1126/sciadv.abk0100 · Cited by 79 · see citing works
Progress in The Development of Paper-Based Diagnostics for Low-Resource Point-Of-Care Settings
Byrnes, S. A., Thiessen, G., & Fu, E. S. (2013) · Bioanalysis · doi:10.4155/bio.13.243 · Cited by 75 · see citing works
Microfluidics for Rapid Detection of Live Pathogens
Rossi, C. S., Coulon, F., Ma, S., Zhang, Y. S., & Yang, Z. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202212081 · Cited by 74 · see citing works
Integrated microfluidic devices for in vitro diagnostics at point of care
Liu, D., Wang, Y., Li, X., Li, M., Wu, Q., Song, Y., Zhu, Z., & Yang, C. J. (2022) · Aggregate · doi:10.1002/agt2.184 · Cited by 75 · see citing works
User-Loaded SlipChip for Equipment-Free Multiplexed Nanoliter-Scale Experiments
Li, L., Du, W., & Ismagilov, R. F. (2009) · Journal of the American Chemical Society · doi:10.1021/ja908555n · Cited by 73 · see citing works
Self-citationCritical Review: digital resolution biomolecular sensing for diagnostics and life science research
Huang, Q., Li, N., Zhang, H., Che, C., Sun, F., Xiong, Y., Canady, T. D., & Cunningham, B. T. (2020) · Lab on a Chip · doi:10.1039/d0lc00506a · Cited by 70 · see citing works
Behavior of a train of droplets in a fluidic network with hydrodynamic traps
Bithi, S. S., & Vanapalli, S. A. (2010) · Biomicrofluidics · doi:10.1063/1.3523053 · Cited by 70 · see citing works
Lab-on-a-chip technologies for massive parallel data generation in the life sciences: A review
Trietsch, S. J., Hankemeier, T., & van der Linden, H. J. (2011) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2011.03.005 · Cited by 71 · see citing works
Akceoglu, G. A., Saylan, Y., & İnci, F. (2021) · Advanced Materials Technologies · doi:10.1002/admt.202100049 · Cited by 69 · see citing works
Chung, S. E., Kim, J., Oh, D. Y., Song, Y., Lee, S. H., Min, S., & Kwon, S. (2014) · Nature Communications · doi:10.1038/ncomms4468 · Cited by 69 · see citing works
Martzy, R., Kolm, C., Krska, R., Mach, R. L., Farnleitner, A. H., & Reischer, G. H. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-1553-1 · Cited by 68 · see citing works
Universal microfluidic platform for bioassays in anchored droplets
Amselem, G., Guermonprez, C., Drogue, B., Michelin, S., & Baroud, C. N. (2016) · Lab on a Chip · doi:10.1039/c6lc00968a · Cited by 67 · see citing works
Graphene-based microfluidics for serial crystallography
Sui, S., Wang, Y., Kolewe, K. W., Šrajer, V., Henning, R. W., Schiffman, J. D., Dimitrakopoulos, C. D., & Perry, S. L. (2016) · Lab on a Chip · doi:10.1039/c6lc00451b · Cited by 65 · see citing works
Enabling miniaturised personalised diagnostics: from lab-on-a-chip to lab-in-a-drop
Koo, K. M., Wee, E. J. H., Wang, Y., & Trau, M. (2017) · Lab on a Chip · doi:10.1039/c7lc00587c · Cited by 65 · see citing works
Microfluidics for single-cell genetic analysis
Thompson, A. M., Paguirigan, A. L., Kreutz, J. E., Radich, J. P., & Chiu, D. T. (2014) · Lab on a Chip · doi:10.1039/c4lc00175c · Cited by 63 · see citing works
Teaching Single-Cell Digital Analysis Using Droplet-Based Microfluidics
Najah, M., Griffiths, A. D., & Ryckelynck, M. (2011) · Analytical Chemistry · doi:10.1021/ac202645m · Cited by 64 · see citing works
Digital detection of biomarkers assisted by nanoparticles: application to diagnostics
Cretich, M., Daaboul, G. G., Solá, L., Ünlü, M. S., & Chiari, M. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.03.002 · Cited by 63 · see citing works
Sun, Y., Zhou, X., & Yu, Y. (2014) · Lab on a Chip · doi:10.1039/c4lc00598h · Cited by 63 · see citing works
Microfluidics for antibiotic susceptibility testing
Postek, W., Pacocha, N., & Garstecki, P. (2022) · Lab on a Chip · doi:10.1039/d2lc00394e · Cited by 63 · see citing works
- Authors
- Du, W., Li, L., Nichols, K. P., & Ismagilov, R. F.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Ismagilov, Rustem F.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 9
- Issue
- 16
- Pages
- 2286
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC2719824
- OpenAlex
- W4249742884
- Cited by
- 351
- References
- 48
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 14 · 2023: 21 · 2022: 19 · 2021: 18 · 2020: 22 · 2019: 25 · 2018: 23 · 2017: 20 · 2016: 34 · 2015: 24 · 2014: 26 · 2013: 29 · 2012: 14
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD003584, GM074961)
- National Institute of General Medical Sciences (R01GM075827, U54GM074961)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › Innovative Microfluidic and Catalytic Techniques Innovation
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrowetting and Microfluidic Technologies
- Keywords
- SlipChip, microfluidics, glass microfluidics, membrane protein crystallization, resource-limited settings
- MeSH terms
- Bacterial Proteins, Food Coloring Agents, Indicators and Reagents, Hyphomicrobiaceae, Photosynthetic Reaction Center Complex Proteins, Microfluidic Analytical Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
