Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works

Extending Applicability of the Oxygen Radical Absorbance Capacity (ORAC−Fluorescein) Assay

Dávalos, A., Gómez‐Cordovés, C., & Bartolomé, B. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0305231 · Cited by 1,211 · see citing works

Oxidative Stress in Neurodegenerative Diseases

Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works

The histamine H3 receptor: from discovery to clinical trials with pitolisant

Schwartz, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01286.x · Cited by 318 · see citing works

Acetylcholinesterase inhibitors: novel activities of old molecules

Racchi, M. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.12.027 · Cited by 291 · see citing works

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Bolea, I., Juárez‐Jiménez, J., Rı́os, C. D. L., Chioua, M., Pouplana, R., Luque, F. J., Unzeta, M., Marco, J. L., & Samadi, A. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200853t · Cited by 220 · see citing works

Keynote review: Histamine H3 receptor antagonists reach out for the clinic

Célanire, S., Wijtmans, M., Talaga, P. E., Leurs, R., & de Esch, I. J. P. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03625-1 · Cited by 210 · see citing works

Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

Fernández‐Bachiller, M. I., Pérez, C., Campillo, N. E., Paez, J. A., González-Muñoz, G. C., Usán, P., García‐Palomero, E., López, M. G., Villarroya, M., Garcı́a, A. G., et al. (2009) · ChemMedChem · doi:10.1002/cmdc.200800414 · Cited by 160 · see citing works

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Sadek, B. S., Saad, A. K., Sadeq, A. S., Jalal, F. Y., & Stark, H. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.051 · Cited by 158 · see citing works

Distinct pharmacology of rat and human histamine H3 receptors: role of two amino acids in the third transmembrane domain

Ligneau, X., Morisset‐Lopez, S., Tardivel‐Lacombe, J., Gbahou, F., Ganellin, C. R., Stark, H., Schunack, W. G., Schwartz, J., & Arrang, J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703712 · Cited by 149 · see citing works

Two Novel and Selective Nonimidazole Histamine H3 Receptor Antagonists A-304121 and A-317920: I. In Vitro Pharmacological Effects

Esbenshade, T. A., Krueger, K. M., Miller, T. R., Kang, C. H., Denny, L. I., Witte, D. G., Yao, B. B., Fox, G. B., Faghih, R., Bennani, Y. L., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047183 · Cited by 102 · see citing works

Characteristics of recombinantly expressed rat and human histamine H3 receptors

Wulff, B. S., Hastrup, S., & Rimvall, K. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02382-8 · Cited by 86 · see citing works

The other side of the histamine H3 receptor

Ellenbroek, B. A., & Ghiabi, B. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.02.007 · Cited by 83 · see citing works

Brain plasticity and cognitive functions after ethanol consumption in C57BL/6J mice

Stragier, E., Martin, V., Davenas, E., Poilbout, C., Mongeau, R., Corradetti, R., & Lanfumey, L. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.183 · Cited by 80 · see citing works

Monoamine oxidases in development

Wang, C. C., Billett, E. E., Borchert, A., Kühn, H., & Ufer, C. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1065-7 · Cited by 77 · see citing works

Searching for the Multi-Target-Directed Ligands against Alzheimer’s disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities

Huang, W., Tang, L., Shi, Y., Huang, S., Xu, L., Sheng, R., Wu, P., Li, J. X., Zhou, N., & Hu, Y. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.09.061 · Cited by 75 · see citing works

Novel Tacrine‐Grafted Ugi Adducts as Multipotent Anti‐Alzheimer Drugs: A Synthetic Renewal in Tacrine–Ferulic Acid Hybrids

Benchekroun, M., Bartolini, M., Egea, J., Romero, A., Soriano, E., Pudlo, M., Luzet, V., Andrisano, V., Jimeno, M. L., López, M. G., et al. (2014) · ChemMedChem · doi:10.1002/cmdc.201402409 · Cited by 74 · see citing works

Histamine receptor subtypes a century of rational drug design

Stark, H. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s279 · Cited by 69 · see citing works

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor

Bautista‐Aguilera, Ó. M., Samadi, A., Chioua, M., Nikolic, K. M., Filipić, S., Agbaba, D., Soriano, E., de Andrés, L., Rodrı́guez-Franco, M. I., Alcaro, S., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501501a · Cited by 67 · see citing works

Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease

Sheng, R., Tang, L., Jiang, L., Hong, L., Shi, Y., Zhou, N., & Hu, Y. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00224 · Cited by 61 · see citing works

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.

Esteban, G., Allan, J., Samadi, A., Mattevi, A., Unzeta, M., Marco-Contelles, J., Binda, C., & Ramsay, R. (2014) · Biochimica et Biophysica Acta · doi:10.1016/j.bbapap.2014.03.006 · Cited by 57 · see citing works

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

Khanfar, M. A., Affini, A., Lutsenko, K., Nikolic, K. M., Butini, S., & Stark, H. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00201 · Cited by 53 · see citing works

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease

Benek, O., Soukup, O., Benková, M., Hroch, L., Šepsová, V., Jošt, P., Hrabinová, M., Jun, D., Kuča, K., Zala, D., et al. (2015) · ChemMedChem · doi:10.1002/cmdc.201500383 · Cited by 37 · see citing works

Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B

Hagenow, S., Stasiak, A., Ramsay, R. R., & Stark, H. (2017) · Scientific Reports · doi:10.1038/srep40541 · Cited by 37 · see citing works

Procognitive Properties of Drugs with Single and Multitargeting H3Receptor Antagonist Activities

Nikolic, K. M., Filipić, S., Agbaba, D. D., & Stark, H. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12279 · Cited by 34 · see citing works

Scaffold variations in amine warhead of histamine H3 receptor antagonists

Wingen, K., & Stark, H. (2013) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2013.07.001 · Cited by 31 · see citing works

Histamine H3R Antagonists: From Scaffold Hopping to Clinical Candidates

Sadek, B. S., Łażewska, D., Hagenow, S., Kieć‐Kononowicz, K., & Stark, H. (2016) · The Receptors · doi:10.1007/978-3-319-40308-3_5 · Cited by 19 · see citing works

Turning from monogamy to strategic promiscuity

Stark, H. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03208-8 · Cited by 17 · see citing works

Pharmacophore modeling, drug design and virtual screening on multi-targeting procognitive agents approaching histaminergic pathways

Nikolic, K. M., Agbaba, D. D., & Stark, H. (2014) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2014.09.017 · Cited by 14 · see citing works

A perspective on multi‐target drug discovery and design for complex diseases

Ramsay, R. R., Popović-Nikolić, M. R., Nikolic, K. M., Uliassi, E., & Bolognesi, M. L. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0181-2 · Cited by 730 · see citing works

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

Proschak, E., Stark, H., & Merk, D. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00760 · Cited by 498 · see citing works

From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology

Albertini, C., Salerno, A., de Sena Murteira Pinheiro, P., & Bolognesi, M. L. (2021) · Medicinal Research Reviews · doi:10.1002/med.21699 · Cited by 179 · see citing works

Alzheimer’s Disease, the “One-Molecule, One-Target” Paradigm, and the Multitarget Directed Ligand Approach

Oset‐Gasque, M. J., & Marco‐Contelles, J. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00069 · Cited by 160 · see citing works

Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease

Rabiee, N., Ahmadi, S., Afshari, R., Khalaji, S., Rabiee, M., Bagherzadeh, M., Fatahi, Y., Dinarvand, R., Tahriri, M., Tayebi, L., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000076 · Cited by 140 · see citing works

MAO inhibitors and their wider applications: a patent review

Carradori, S., Secci, D., & Petzer, J. P. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1427735 · Cited by 139 · see citing works

Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update

Tripathi, R. K. P., & Ayyannan, S. R. (2019) · Medicinal Research Reviews · doi:10.1002/med.21561 · Cited by 136 · see citing works

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer’s disease (1998–2018)

Mishra, P., Kumar, A., & Panda, G. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.025 · Cited by 128 · see citing works

Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress

Sang, Z., Wang, K., Dong, J., & Tang, L. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114464 · Cited by 127 · see citing works

Kinetics, mechanism, and inhibition of monoamine oxidase

Ramsay, R. R., & Albreht, A. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1861-9 · Cited by 108 · see citing works

Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease

Mao, Q., Qin, W., Zhang, A., & Ye, N. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0365-y · Cited by 92 · see citing works

Small-Molecule Inhibitors of Reactive Oxygen Species Production

Sassetti, E., Clausen, M. H., & Laraia, L. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01914 · Cited by 84 · see citing works

The current status of pharmacotherapy for the treatment of Parkinson’s disease: transition from single-target to multitarget therapy

Cheong, S. L., Federico, S., Spalluto, G., Klotz, K., & Pastorin, G. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.05.003 · Cited by 72 · see citing works

Histamine H3 receptor antagonists/inverse agonists: Where do they go?

Ghamari, N., Zarei, O., Arias‐Montaño, J., Reiner‐Link, D., Dastmalchi, S., Stark, H., & Hamzeh‐Mivehroud, M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.007 · Cited by 65 · see citing works

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Bautista‐Aguilera, Ó. M., Budni, J., Mina, F., Medeiros, E. B., Deuther‐Conrad, W., Entrena, J. M., Moraleda, I., Iriepa, I., Lopez-Munoz, F. J., & Marco, J. L. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00848 · Cited by 64 · see citing works

Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?

Guglielmi, P., Carradori, S., Ammazzalorso, A., & Secci, D. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1637415 · Cited by 58 · see citing works

Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease

Kumar, R., Kumar, V., Kumar, B., Thakur, A., & Dwivedi, A. R. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210512005508 · Cited by 54 · see citing works

Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson’s disease

Affini, A., Hagenow, S., Živković, A., Marco, J. L., & Stark, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.02.015 · Cited by 53 · see citing works

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Lalut, J., Santoni, G., Karila, D., Lecoutey, C., Davis, A., Nachon, F., Silman, I., Sussman, J. L., Weik, M., Maurice, T., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.10.064 · Cited by 52 · see citing works

Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease

Hafez, D. E., Dubiel, M., Spada, G. L., Catto, M., Reiner‐Link, D., Syu, Y.-T., Abdel‐Halim, M., Hwang, T., Stark, H., & Abadi, A. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2175821 · Cited by 50 · see citing works

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

Szczepańska, K., Podlewska, S., Dichiara, M., Gentile, D., Patamia, V., Rosier, N., Mönnich, D., Ruiz‐Cantero, M. C., Karcz, T. P., Łażewska, D., et al. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00435 · Cited by 48 · see citing works

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies

Elshaflu, H., Todorović, T. R., Nikolic, M. R., Lolić, A., Višnjevac, A., Hagenow, S., Padrón, J. M., García‐Sosa, A. T., Đorđević, I., Grubišić, S., et al. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00247 · Cited by 47 · see citing works

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

Knez, D., Diez‐Iriepa, D., Chioua, M., Gottinger, A., Denic, M., Chantegreil, F., Nachon, F., Brazzolotto, X., Skrzypczak-Wiercioch, A., Meden, A., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.013 · Cited by 46 · see citing works

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

Panek, D., Więckowska, A., Pasieka, A., Godyń, J., Jończyk, J., Bajda, M., Knez, D., Gobec, S., & Malawska, B. (2018) · Molecules · doi:10.3390/molecules23020347 · Cited by 46 · see citing works

Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands

Rodríguez‐Soacha, D. A., Scheiner, M., & Decker, M. W. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.040 · Cited by 44 · see citing works

Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy

Carreiras, M. C., Ismaïli, L., & Marco, J. L. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126880 · Cited by 45 · see citing works

New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H ₃ Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

Malek, R., Arribas, R. L., Palomino-Antolin, A., Totoson, P., Demougeot, C., Kobrlova, T., Soukup, O., Iriepa, I., Moraleda, I., Diez-Iriepa, D., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00937 · Cited by 45 · see citing works

Enhancing the Therapeutic Effect in Alzheimer's Disease Drugs: The role of Polypharmacology and Cholinesterase inhibitors

Martins, M. M., Branco, P. S., & Ferreira, L. M. (2023) · ChemistrySelect · doi:10.1002/slct.202300461 · Cited by 45 · see citing works

Recent advances in multitarget-directed ligands targeting G-protein-coupled receptors

Ma, H., Huang, B., & Zhang, Y. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.07.004 · Cited by 43 · see citing works

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies

Rullo, M., Cipolloni, M., Catto, M., Colliva, C., Miniero, D. V., Latronico, T., de Candia, M., Benicchi, T., Linusson, A., Giacchè, N., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01784 · Cited by 41 · see citing works

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands

Szczepańska, K., Karcz, T. P., Mogilski, S., Siwek, A., Kuder, K., Latacz, G., Kubacka, M., Hagenow, S., Lubelska, A., Olejarz‐Maciej, A., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.043 · Cited by 34 · see citing works

Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s disease

Łażewska, D., Bajda, M., Kaleta, M., Zaręba, P., Doroż-Płonka, A., Siwek, A., Alachkar, A., Mogilski, S., Saad, A. K., Kuder, K., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112743 · Cited by 31 · see citing works

Molecular Modeling of Histamine Receptors—Recent Advances in Drug Discovery

Mehta, P., Miszta, P., & Filipek, S. (2021) · Molecules · doi:10.3390/molecules26061778 · Cited by 31 · see citing works

Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017)

Łażewska, D., & Kieć‐Kononowicz, K. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1424135 · Cited by 29 · see citing works

Novel naphthyloxy derivatives – Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation

Łażewska, D., Kaleta, M., Hagenow, S., Mogilski, S., Latacz, G., Karcz, T. P., Lubelska, A., Honkisz-Orzechowska, E., Handzlik, J., Reiner‐Link, D., et al. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.04.023 · Cited by 29 · see citing works

New tacrine–acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease

Chufarova, N. V., Czarnecka, K., Skibiński, R., Cuchra, M., Majsterek, I., & Szymański, P. (2018) · Archiv der Pharmazie · doi:10.1002/ardp.201800050 · Cited by 28 · see citing works

Parameters for Irreversible Inactivation of Monoamine Oxidase

Ramsay, R. R., Basile, L., Maniquet, A., Hagenow, S., Pappalardo, M., Saija, M. C., Bryant, S. D., Albreht, A., & Guccione, S. (2020) · Molecules · doi:10.3390/molecules25245908 · Cited by 27 · see citing works

Dual Piperidine-Based Histamine H 3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain

Szczepańska, K., Karcz, T. P., Dichiara, M., Mogilski, S., Kalinowska‐Tłuścik, J., Pilarski, B., Leniak, A., Pietruś, W., Podlewska, S., Popiołek-Barczyk, K., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00430 · Cited by 24 · see citing works

Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands

Lopes, F. B., Aranha, C. M. S. Q., & Fernandes, J. P. S. (2021) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13866 · Cited by 21 · see citing works

Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer’s disease

Godyń, J., Zaręba, P., Łażewska, D., Stary, D., Reiner‐Link, D., Frank, A., Latacz, G., Mogilski, S., Kaleta, M., Doroż-Płonka, A., et al. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105129 · Cited by 21 · see citing works

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors

Łażewska, D., Olejarz‐Maciej, A., Reiner‐Link, D., Kaleta, M., Latacz, G., Zygmunt, M., Doroż-Płonka, A., Karcz, T. P., Frank, A., Stark, H., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103411 · Cited by 21 · see citing works

Multitarget-directed Ligands for Neurodegenerative Diseases: Real Opportunity Or Blurry mirage?

Benchekroun, M., & Maramai, S. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0249 · Cited by 20 · see citing works

Synthesis of Chromone‐Containing Allylmorpholines through a Morita–Baylis–Hillman‐Type Reaction

Chernov, N. M., Shutov, R. V., Barygin, O. I., Dron, M. Y., Старова, Г. Л., Kuzmich, N. N., & Yakovlev, I. P. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201801159 · Cited by 19 · see citing works

Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases

Toledano‐Pinedo, M., Porro-Pérez, A., Schäker‐Hübner, L., Romero, F., Dong, M., Samadi, A., Almendros, P., Iriepa, I., Bautista‐Aguilera, Ó. M., Rodríguez‐Fernández, M. M., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01367 · Cited by 19 · see citing works

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands

Szczepańska, K., Karcz, T. P., Siwek, A., Kuder, K., Latacz, G., Bednarski, M., Szafarz, M., Hagenow, S., Lubelska, A., Olejarz‐Maciej, A., et al. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103071 · Cited by 18 · see citing works

4-tert-Pentylphenoxyalkyl derivatives – Histamine H3 receptor ligands and monoamine oxidase B inhibitors

Łażewska, D., Olejarz‐Maciej, A., Kaleta, M., Bajda, M., Siwek, A., Karcz, T. P., Doroż-Płonka, A., Cichoń, U., Kuder, K., & Kieć‐Kononowicz, K. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.10.048 · Cited by 18 · see citing works

The Evolution of AChE Inhibitors in Alzheimer's Disease: From Single‐Target to Multi‐Target Ligands

Mehta, N. V., Kapadia, A., Khambete, M., & Abhyankar, A. N. (2025) · ChemBioChem · doi:10.1002/cbic.202500053 · Cited by 17 · see citing works

An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors

Sharma, P., Singh, M., & Mathew, B. (2021) · ChemistrySelect · doi:10.1002/slct.202004188 · Cited by 17 · see citing works

Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Guiselin, T., Lecoutey, C., Rochais, C., & Dallemagne, P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102382 · Cited by 16 · see citing works

Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson’s Disease

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Hu, C., Jiang, L., Tang, L., Zhang, M.-K., & Sheng, R. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116306 · Cited by 11 · see citing works

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Diez‐Iriepa, D., Knez, D., Gobec, S., Iriepa, I., Rı́os, C. D. L., Bravo, I., Lopez-Munoz, F. J., Marco‐Contelles, J., & Hadjipavlou‐Litina, D. (2022) · Antioxidants · doi:10.3390/antiox11091735 · Cited by 10 · see citing works

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Chen, J., Zhu, H., Luo, K., Luo, Q., Wang, Y., Liu, T., Li, L., Dai, Z., Yang, S., Li, Y., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107704 · Cited by 8 · see citing works

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Mastromarino, M., Niso, M., Abate, C., Proschak, E., Dubiel, M., Stark, H., Castro, M., Lacivita, E., & Leopoldo, M. (2022) · Molecules · doi:10.3390/molecules27041297 · Cited by 8 · see citing works

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Łażewska, D., Zaręba, P., Godyń, J., Doroż-Płonka, A., Frank, A., Reiner‐Link, D., Bajda, M., Stary, D., Mogilski, S., Olejarz‐Maciej, A., et al. (2021) · Molecules · doi:10.3390/molecules26123580 · Cited by 7 · see citing works

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Kuder, K., Kotańska, M., Szczepańska, K., Mika, K., Reiner‐Link, D., Stark, H., & Kieć‐Kononowicz, K. (2021) · Molecules · doi:10.3390/molecules26082300 · Cited by 7 · see citing works

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Łażewska, D., & Kieć‐Kononowicz, K. (2024) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2024.2446227 · Cited by 6 · see citing works

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Pasieka, A., Panek, D., & Malawska, B. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch11 · Cited by 6 · see citing works

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Lopes, F. B., Aranha, C. M. S. Q., Corrêa, M. F., Fernandes, G. A. B., Okamoto, D. N., Simões, L. P. M., Nascimento-Júnior, N. M., & Fernandes, J. P. S. (2022) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14139 · Cited by 6 · see citing works

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Alonso, J. M., Escobar-Peso, A., Palomino‐Antolín, A., Diez‐Iriepa, D., Chioua, M., Martínez‐Alonso, E., Iriepa, I., Egea, J., Alcázar, A., & Marco, J. L. (2021) · Pharmaceuticals · doi:10.3390/ph14090861 · Cited by 5 · see citing works

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Guo, Z., Gu, J., Zhang, M., Su, F., Su, W., & Xie, Y. (2023) · Biomolecules · doi:10.3390/biom13040600 · Cited by 5 · see citing works

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Dias, I., Emmanuel, M., Vogt, P., Guerreiro-Oliveira, C., Melo-Marques, I., Cardoso, S. M., Guedes, R. C., Chaves, S., & Santos, M. A. (2025) · Antioxidants · doi:10.3390/antiox14080921 · Cited by 3 · see citing works

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Tanwir, S. E., & Kumar, A. (2019) · Open Journal of Medicinal Chemistry · doi:10.4236/ojmc.2019.91001 · Cited by 3 · see citing works

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Rao, P. P. N., Pham, A. T., & Shakeri, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818349-6.00011-x · Cited by 3 · see citing works

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Valenzuela-Hormazábal, P., Valero-Rojas, J., Martínez‐González, L., Ramos-Inza, S., Oviedo-Pino, V., González-Ortega, C., Hernando, G., López, J. J., Scorza, C., Echeverry, C., et al. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c02202 · Cited by 2 · see citing works

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Añazco, T., Werner, T., Torres, M. J., Hornos‐Carneiro, M. F., Fernández, J., Živković, A., Salas, C. O., Castro‐Álvarez, A., Gutiérrez, M., Stark, H., et al. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.202400387 · Cited by 2 · see citing works

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Yang, Y., Ibrahim, W., Gravel, P., Pittman, B. P., Hoye, J., Cool, R., Sadabad, F. E., Zheng, M., Pittenger, C., Gallezot, J., et al. (2025) · Molecular Imaging and Biology · doi:10.1007/s11307-025-02047-8 · Cited by 1 · see citing works

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Egyed, A., Kiss, D. J., Pável, Z., Rajna, K., Gaitonde, S. A., Dubiel, M., Loza, M. I., Szűcs, E., Borbély, É., Hajna, Z., et al. (2025) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2025.100302 · Cited by 1 · see citing works

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Haghighi, F. H., Xie, J., Ebert, E., & Siahaan, T. J. (2026) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2026.2663114 · Cited by 1 · see citing works

Privileged Multi-Target Directed Propargyl-Tacrines Combining Cholinesterase and Monoamine Oxidase Inhibition ActivitiesPreprint

Chrienová, Ž., Nepovimová, E., Andrýs, R., Doležal, R., Janočková, J., Múčková, Ľ., Nemcikova, L., Soukup, O., Olekšák, P., Vališ, M., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4056753 · Cited by 1 · see citing works

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Bautista‐Aguilera, Ó. M., Hagenow, S., Palomino‐Antolín, A., Farré‐Alins, V., Ismaïli, L., Joffrin, P., Jimeno, M. L., Soukup, O., Janočková, J., Kalinowsky, L., et al. (2017) · Angewandte Chemie · doi:10.1002/ange.201706072 · Cited by 3 · see citing works

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Lopes, F. D. P. D. L. [. (2023) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

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Łażewska, D., Kaleta, M., Zaręba, P., Godyń, J., Dubiel, M., Honkisz-Orzechowska, E., Doroż-Płonka, A., Więckowska, A., Stark, H., & Kieć‐Kononowicz, K. (2023) · Molecules · doi:10.3390/molecules28052349 · Cited by 7 · see citing works

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Ramsay, R. R., Májeková, M., Medina, M., & Valoti, M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00375 · Cited by 74 · see citing works