New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

A new and rapid colorimetric determination of acetylcholinesterase activity

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Alzheimer’s disease

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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

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Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay Using Fluorescein as the Fluorescent Probe

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Automated comparative protein structure modeling with SWISS‐MODEL and Swiss‐PdbViewer: A historical perspective

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The SWISS-MODEL Repository—new features and functionality

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Extending Applicability of the Oxygen Radical Absorbance Capacity (ORAC−Fluorescein) Assay

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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

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Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

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Therapeutic strategies for Alzheimer's disease in clinical trials

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Increased NF-Κb Signalling Up-Regulates BACE1 Expression and its Therapeutic Potential in Alzheimer's Disease

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The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model.

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Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

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Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

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Tacrine Derivatives and Alzheimers Disease

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Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?

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Histamine H3 Receptor Antagonists Go to Clinics

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Alzheimer’s Disease, the “One-Molecule, One-Target” Paradigm, and the Multitarget Directed Ligand Approach

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Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine

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Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

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The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

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Butyrylcholinesterase and the cholinergic system

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Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H₃R Antagonism for Neurodegenerative Diseases

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Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a “Bio-Oxidizable” Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation

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The cholinergic pathology in Alzheimer's disease - discrepancies between clinical experience and pathophysiological findings

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Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

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Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

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The other side of the histamine H3 receptor

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The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease

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Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling

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Donepezil–Ferulic Acid Hybrids as Anti-Alzheimer Drugs

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Histamine receptor subtypes a century of rational drug design

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Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Bautista‐Aguilera, Ó. M., Budni, J., Mina, F., Medeiros, E. B., Deuther‐Conrad, W., Entrena, J. M., Moraleda, I., Iriepa, I., Lopez-Munoz, F. J., & Marco, J. L. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00848 · Cited by 64 · see citing works

Recent advances in histamine H3receptor antagonists/inverse agonists

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Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

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Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

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Tau in neurodegenerative diseases: Tau phosphorylation and assembly

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New 5-Unsubstituted Dihydropyridines with Improved CaV1.3 Selectivity as Potential Neuroprotective Agents against Ischemic Injury

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Memantine in Patients with Moderate to Severe Alzheimer's Disease: Meta-Analyses Using Realistic Definitions of Response

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A Novel Method for Resolution of Amlodipine

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Retrospective Study on the Benefits of Combined Memantine and cholinEsterase inhibitor treatMent in AGEd Patients affected with Alzheimer's Disease: The MEMAGE Study

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Ligand Based Approach to L-Type Calcium Channel by Imidazo[2,1-b]thiazole-1,4-Dihydropyridines: from Heart Activity to Brain Affinity

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Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1–calcium interaction

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Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer’s disease

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Multicomponent Reactions for Multitargeted Compounds for Alzheimer`s Disease

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Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy

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Pharmacology, Efficacy and Safety of Felodipine with a Focus on Hypertension and Angina Pectoris

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From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology

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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

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Herbicide Antagonism at the Whole Plant Level

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