The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
An Intracellular H2O2‐Responsive AIEgen for the Peroxidase‐Mediated Selective Imaging and Inhibition of Inflammatory Cells
Abstract
Inflammatory cells have gained widespread attention because inflammatory diseases increase the risk for many types of cancer. Therefore, it is urgent and important to implement detection and treatment methods for inflammatory cells. Herein, we constructed a theranostic probe with aggregation‐induced emission (AIE) characteristics, in which tetraphenylethene (TPE) was modified with two tyrosine (Tyr) moieties. Owing to the H 2 O 2‐dependent, enzyme‐catalyzed dityrosine formation, Tyr‐containing TPE (TT) molecules crosslink through dityrosine linkages to induce the formation of hydrophobic aggregates, activating the AIE process in inflammatory cells that contain H 2 O 2 and overexpress myeloperoxidase. The emission turn‐on resulting from the crosslinking of TT molecules could be used to distinguish between inflammatory and normal cells. Moreover, the massive TT aggregates induced mitochondria damage and cell apoptosis. This study demonstrates that the H 2 O 2‐responsive peroxidase‐activated AIEgen holds great promise for inflammatory‐cell selective imaging and inhibition.
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Cites
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Regulation of cancer cell metabolism
Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744
Neurodegenerative diseases and oxidative stress
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Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
Cited by
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Zhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Niu, G., Zheng, X., Zhao, Z., Zhang, H., Wang, J., He, X., Chen, Y., Shi, X., Ma, C., Kwok, R. T. K., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b06196 · Cited by 183
Hu, J., Jiang, W., Yuan, L., Duan, C., Yuan, Q., Long, Z., Lou, X., & Xia, F. (2021) · Aggregate · doi:10.1002/agt2.10 · Cited by 172
Self-citation
Metadata
- Authors
- Cheng, Y., Dai, J., Sun, C., Liu, R., Zhai, T., Lou, X., & Xia, F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-02-21
- Volume
- 57
- Issue
- 12
- Pages
- 3123-3127
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2792396837
- Cited by
- 241
- References
- 7
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, Y., Dai, J., Sun, C., Liu, R., Zhai, T., Lou, X., & Xia, F. (2018). An Intracellular H2O2‐Responsive AIEgen for the Peroxidase‐Mediated Selective Imaging and Inhibition of Inflammatory Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201712803
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