Gathering brings strength: How organic aggregates boost disease phototheranostics

Qi, Ji; Ou, Hanlin; Liu, Qian; Ding, Dan

doi:10.1002/agt2.25

Cited by 284Luminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPhotochemistry and Electron Transfer Studies

Gathering brings strength: How organic aggregates boost disease phototheranostics

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Qi, Ji, Ou, Hanlin, Liu, Qian, Ding, Dan·2021·Aggregate

DOI 10.1002/agt2.25

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Abstract

Phototheranostics that concurrently and complementarily integrate real‐time diagnosis and in situ therapeutic capabilities in one platform has become the advancing edge of precision medicine. Organic agents possess the merits of facile preparation, high purity, tunable photophysical property, good biocompatibility, and potential biodegradability, which have shown great promise for disease theranostics. This review summarizes the recent achievements of organic phototheranostic agents and applications, especially which rationally utilize energy dissipation pathways of Jablonski diagram to modulate the fluorescence emission, photoacoustic/photothermal production, and photodynamic processes. Of particular interest are the systems exhibiting huge differences in aggregate state as compared with the solution or single molecule form, during which the intramolecular motions play an important role in regulating the photophysical properties. The recent advances from such an aspect for biomedical applications including high‐resolution imaging, activatable imaging and therapy, adaptive theranostics, image‐guided surgery, immunotherapy, and afterglow imaging are discussed. A brief summary and perspective in this field are also presented. We hope this review will be helpful to the researchers interested in bioprobe design and theranostic applications, and inspire new insights into the linkage between aggregate science and biomedical field.

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Most available NIR-II fluorophores are prone to aggregation-caused quenching in practical applications, which typically reduces photoluminescence quantum yields to below 2%.
“However, these NIR-II fluorophores are prone to aggregation-caused quenching (ACQ) in practical applications16–19, which typically reduces ΦPL values to below 2% (Table S1).”
From Alleviating NIR-II emission quenching in ring-fused fluorophore via manipulating dimer populations for superior fluorescence imaging (2025) · cites this paper as [18]

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Modular Design of Peptide- or DNA-Modified AIEgen Probes for Biosensing Applications
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In Situ Self‐Assembled Nanofibers Precisely Target Cancer‐Associated Fibroblasts for Improved Tumor Imaging
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A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria
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Authors: Qi, J., Ou, H., Liu, Q., & Ding, D.
Affiliations: Nankai University (CN)
Tianjin First Center Hospital (CN)
Corresponding author: Ding, Dan
ORCID: Qi, Ji
Ou, Hanlin
Liu, Qian
Ding, Dan
Venue: Aggregate
Publisher: Wiley
Published: 2021-01-22
Volume: 2
Issue: 1
Pages: 95-113
ISSN: 2692-4560 (ISSN-L)
DOI: 10.1002/agt2.25
OpenAlex: W3122276378
Cited by: 284
References: 201
Citations by year: 2026: 10 · 2025: 40 · 2024: 58 · 2023: 78 · 2022: 68 · 2021: 30
FWCI: 17.77
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Aggregate (publishedVersion, cc-by)
Funders: National Natural Science Foundation of China (51673150, 51873092, 51961160730)
Nankai University
Tianjin Municipal Bureau of Public Health
Fundamental Research Funds for the Central Universities
Science Fund for Distinguished Young Scholars of Tianjin (19JCJQJC61200)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
Keywords: phototheranostics, aggregate states, Jablonski diagram, fluorescence quenching, photoacoustic imaging, photothermal therapy, photodynamic therapy, intramolecular motion, afterglow imaging, image-guided surgery, immunotherapy, bioprobes

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