The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
An Activatable AIEgen Probe for High‐Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision
Abstract
Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM‐ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The probe consists of a quinoline‐malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP‐recognition units. The rapid liberation of DQM‐OH aggregates in the presence of ALP resulted in aggregation‐induced fluorescence. The up‐regulation of ALP expression in tumor cells was imaged using DQM‐ALP. The probe permeated into 3D cervical and liver tumor spheroids for imaging spatially heterogeneous ALP activity with high spatial resolution on a two‐photon microscopy platform, providing the fluorescence‐guided recognition of sub‐millimeter tumorigenesis. DQM‐ALP enabled differentiation between tumor and normal tissue ex vivo and in vivo, suggesting that the probe may serve as a powerful tool to assist surgeons during tumor resection.
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Cites
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
Tsujii, M., Kawano, S., & DuBois, R. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3336 · Cited by 1,398
Small-Molecule Two-Photon Probes for Bioimaging Applications
Kim, H. M., & Cho, B. R. (2015) · Chemical Reviews · doi:10.1021/cr5004425 · Cited by 1,047
Aggregation-Induced Emission Luminogens for Activity-Based Sensing
Wang, D., & Tang, B. Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00305 · Cited by 510
Cited by
Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy
Li, H., Kim, Y., Jung, H., Hyun, J. Y., & Shin, I. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00722c · Cited by 356
Self-citationZeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Self-citationQin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202201541 · Cited by 140
Metadata
- Authors
- Li, H., Yao, Q., Xu, F., Li, Y., Kim, D., Chung, J., Baek, G., Wu, X., Hillman, P. F., Lee, E. Y., Ge, H., Fan, J., Wang, J., Nam, S., Peng, X., & Yoon, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-03-10
- Volume
- 59
- Issue
- 25
- Pages
- 10186-10195
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3011351825
- Cited by
- 192
- References
- 5
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, H., Yao, Q., Xu, F., Li, Y., Kim, D., Chung, J., Baek, G., Wu, X., Hillman, P. F., Lee, E. Y., Ge, H., Fan, J., Wang, J., Nam, S., Peng, X., & Yoon, J. (2020). An Activatable AIEgen Probe for High‐Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202001675
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