The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs
Abstract
Redox homeostasis is one of the main reasons for reactive oxygen species (ROS) tolerance in hypoxic tumors, limiting ROS‐mediated tumor therapy. Proposed herein is a redox dyshomeostasis (RDH) strategy based on a nanoplatform, FeCysPW@ZIF‐82@CAT Dz, to disrupt redox homeostasis, and its application to improve ROS‐mediated hypoxic tumor therapy. Once endocytosed by tumor cells, the catalase DNAzyme (CAT Dz) loaded zeolitic imidazole framework‐82 (ZIF‐82@CAT Dz) shell can be degraded into Zn 2+as cofactors for CAT Dz mediated CAT silencing and electrophilic ligands for glutathione (GSH) depletion under hypoxia, both of which lead to intracellular RDH and H 2 O 2 accumulation. These “disordered” cells show reduced resistance to ROS and are effectively killed by ferrous cysteine‐phosphotungstate (FeCysPW) induced chemodynamic therapy (CDT). In vitro and in vivo data demonstrate that the pH/hypoxia/H 2 O 2 triple stimuli responsive nanocomposite can efficiently kill hypoxic tumors. Overall, the RDH strategy provides a new way of thinking about ROS‐mediated treatment of hypoxic tumors.
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Cites
Drug combination studies and their synergy quantification using the Chou-Talalay method
Chou, T.-C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1947 · Cited by 5,739
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277
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Self-citation
Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances
Jia, C., Guo, Y., & Wu, F. (2022) · Small · doi:10.1002/smll.202103868 · Cited by 685
Selective Targeting of Cancer Cells by Copper Ionophores: An Overview
Oliveri, V. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.841814 · Cited by 367
Strategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 284
Liu, B., Bian, Y., Liang, S., Yuan, M., Dong, S., He, F., Gai, S., Yang, P., Cheng, Z., & Lin, J. (2022) · ACS Nano · doi:10.1021/acsnano.1c07893 · Cited by 257
Metadata
- Authors
- Li, Y., Zhao, P., Gong, T., Wang, H., Jiang, X., Cheng, H., Liu, Y., Wu, Y., & Bu, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-09-30
- Volume
- 59
- Issue
- 50
- Pages
- 22537-22543
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3081996782
- Cited by
- 197
- References
- 3
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Y., Zhao, P., Gong, T., Wang, H., Jiang, X., Cheng, H., Liu, Y., Wu, Y., & Bu, W. (2020). Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202003653
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