The DOI matches its Crossref record; 60 of the 62 references it cites were found in a registry or an index.
Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging
Abstract
Here, we describe a fluorination strategy for semiconducting polymers for the development of highly bright second near‐infrared region (NIR‐II) probes. Tetrafluorination yielded a fluorescence QY of 3.2 % for the polymer dots (Pdots), over a 3‐fold enhancement compared to non‐fluorinated counterparts. The fluorescence enhancement was attributable to a nanoscale fluorous effect in the Pdots that maintained the molecular planarity and minimized the structure distortion between the excited state and ground state, thus reducing the nonradiative relaxations. By performing through‐skull and through‐scalp imaging of the brain vasculature of live mice, we quantitatively analyzed the vascular morphology of transgenic brain tumors in terms of the vessel lengths, vessel branches, and vessel symmetry, which showed statistically significant differences from the wild type animals. The bright NIR‐II Pdots obtained through fluorination chemistry provide insightful information for precise diagnosis of the malignancy of the brain tumor.
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“This strategy was recently applied to develop highly fluorescent CPs in the SWIR spectral window.170,178”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [178]
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A small-molecule dye for NIR-II imaging
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Self-citationNanomaterials for In Vivo Imaging
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Through-skull fluorescence imaging of the brain in a new near-infrared window
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Self-citationAcceptor engineering for NIR-II dyes with high photochemical and biomedical performance
Ji, A., Lou, H., Qu, C., Lu, W., Hao, Y., Li, J., Wu, Y., Chang, T., Chen, H., & Cheng, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31521-y · Cited by 183
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Metadata
- Authors
- Liu, Y., Liu, J., Chen, D., Wang, X., Zhang, Z., Yang, Y., Jiang, L., Qi, W., Ye, Z., He, S., Liu, Q., Xi, L., Zou, Y., & Wu, C.
- Affiliations
- Central South University (CN)
- Southern University of Science and Technology (CN)
- Corresponding author
- Zou, Yingping
- Wu, Changfeng
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-09-08
- Volume
- 59
- Issue
- 47
- Pages
- 21049-21057
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3047818792
- Cited by
- 173
- References
- 62
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 29 · 2023: 39 · 2022: 36 · 2021: 29 · 2020: 4
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality (KQTD20170810111314625)
- National Natural Science Foundation of China (81771930, 51673215)
- National Basic Research Program of China (2018YFB0407200)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- fluorination, polymer dots, NIR-II fluorescence, semiconducting polymers, fluorescence quantum yield enhancement, brain tumor imaging, cerebral vasculature, transgenic mouse model
- MeSH terms
- Animals, Brain Neoplasms, Fluorescence, Fluorescent Dyes, Mice, Inbred C57BL, Particle Size, Polymers, Semiconductors, Surface Properties, Molecular Structure, Quantum Dots, Mice, Halogenation, Optical Imaging
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