Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

The 2007 WHO Classification of Tumours of the Central Nervous System

Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675

Aggregation-induced emission: phenomenon, mechanism and applications

Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2009) · Chemical Communications · doi:10.1039/b904665h · Cited by 4,153

Near-infrared fluorophores for biomedical imaging

Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048

A small-molecule dye for NIR-II imaging

Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778

Organic fluorine compounds: a great opportunity for enhanced materials properties

Berger, R., Resnati, G., Metrangolo, P., Weber, E., & Hulliger, J. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00221f · Cited by 1,520

Multifunctional nanoparticles for multimodal imaging and theragnosis

Lee, D., Koo, H., Sun, I., Ryu, J. H., Kim, K., & Kwon, I. C. (2011) · Chemical Society Reviews · doi:10.1039/c2cs15261d · Cited by 1,433

Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine

Wu, C., & Chiu, D. T. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201205133 · Cited by 1,111

Nanomaterials for In Vivo Imaging

Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,084

Through-skull fluorescence imaging of the brain in a new near-infrared window

Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052

Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications

Feng, L., Zhu, C., Yuan, H., Liu, L., Lv, F., & Wang, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60036j · Cited by 873

In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near‐Infrared Region

Hong, G., Robinson, J. T., Zhang, Y., Diao, S., Antaris, A. L., Wang, Q., & Dai, H. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206059 · Cited by 742

Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging

Wu, C., Bull, B., Szymanski, C. J., Christensen, K., & McNeill, J. (2008) · ACS Nano · doi:10.1021/nn800590n · Cited by 723

Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window

Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563

Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Miao, Q., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201801778 · Cited by 541

Beyond the margins: real-time detection of cancer using targeted fluorophores

Zhang, R. R., Schroeder, A. B., Grudzinski, J. J., Rosenthal, E. L., Warram, J. M., Pinchuk, A. N., Eliceiri, K. W., Kuo, J. S., & Weichert, J. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.212 · Cited by 503

Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects

Kunjachan, S., Ehling, J., Storm, G., Kiessling, F. M., & Lammers, T. (2015) · Chemical Reviews · doi:10.1021/cr500314d · Cited by 488

The fluorous effect in biomolecular applications

Cametti, M., Crousse, B., Metrangolo, P., Milani, R., & Resnati, G. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15084g · Cited by 486

Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy

Li, J., Rao, J., & Pu, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.025 · Cited by 472

Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm

Diao, S., Blackburn, J. L., Hong, G., Antaris, A. L., Chang, J., Wu, J. Z., Zhang, B., Cheng, K., Kuo, C. J., & Dai, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201507473 · Cited by 417

Soft fluorescent nanomaterials for biological and biomedical imaging

Peng, H., & Chiu, D. T. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00294f · Cited by 408

The Curious Case of Fluorination of Conjugated Polymers for Solar Cells

Zhang, Q., Kelly, M. A., Bauer, N., & You, W. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00326 · Cited by 379

Fluorinated Copolymer PCPDTBT with Enhanced Open-Circuit Voltage and Reduced Recombination for Highly Efficient Polymer Solar Cells

Albrecht, S., Janietz, S., Schindler, W., Frisch, J., Kurpiers, J., Kniepert, J., Inal, S., Pingel, P., Fostiropoulos, K., Koch, N., et al. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305039j · Cited by 372

Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting

Wu, C., Hansen, S. J., Hou, Q., Yu, J., Zeigler, M. B., Jin, Y., Burnham, D. R., McNeill, J., Olson, J. M., & Chiu, D. T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007461 · Cited by 364

“Conformation Locked” Strong Electron-Deficient Poly(p-Phenylene Vinylene) Derivatives for Ambient-Stable n-Type Field-Effect Transistors: Synthesis, Properties, and Effects of Fluorine Substitution Position

Lei, T., Xia, X., Wang, J., Liu, C., & Pei, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412533d · Cited by 348

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201307346 · Cited by 330

Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

Jiang, L., Bai, H., Liu, L., Lv, F., Ren, X., & Wang, S. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201905884 · Cited by 289

Fine-Tuning of Crystal Packing and Charge Transport Properties of BDOPV Derivatives through Fluorine Substitution

Dou, J., Zheng, Y., Yao, Z., Yu, Z., Lei, T., Shen, X., Luo, X., Sun, J., Zhang, S., Ding, Y., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b11114 · Cited by 288

Tm3+‐Sensitized NIR‐II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding

Zhang, H., Fan, Y., Pei, P., Sun, C., Lu, L., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903536 · Cited by 288

Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window

Zhu, S., Yang, Q., Antaris, A. L., Yue, J., Ma, Z., Wang, H., Huang, W., Wan, H., Wang, J., Diao, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617990114 · Cited by 281

Light-Harvesting and Amplified Energy Transfer in Conjugated Polymer Nanoparticles

Jiang, Y., & McNeill, J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00419 · Cited by 274

Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914397 · Cited by 242

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie · doi:10.1002/ange.201307346 · Cited by 239

3D NIR‐II Molecular Imaging Distinguishes Targeted Organs with High‐Performance NIR‐II Bioconjugates

Zhu, S., Herraiz, S., Yue, J., Zhang, M., Wan, H., Yang, Q., Ma, Z., Wang, Y., He, J. H., Antaris, A. L., et al. (2018) · Advanced Materials · doi:10.1002/adma.201705799 · Cited by 216

Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near‐Infrared Ag2S Quantum Dots

Chen, G., Tian, F., Zhang, Y., Zhang, Y., Li, C., & Wang, Q. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201303263 · Cited by 214

Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery

Shou, K., Tang, Y., Chen, H., Chen, S., Zhang, L., Zhang, A., Fan, Q., Yu, A., & Cheng, Z. (2018) · Chemical Science · doi:10.1039/c8sc00206a · Cited by 199

Quinoxaline-Based Polymer Dots with Ultrabright Red to Near-Infrared Fluorescence for In Vivo Biological Imaging

Liu, H.-Y., Wu, P.-J., Kuo, S.-Y., Chen, C.-P., Chang, E.-H., Wu, C.-Y., & Chan, Y.-H. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b06710 · Cited by 181

High Affinity to Skeleton Rare Earth Doped Nanoparticles for Near-Infrared II Imaging

He, S., Chen, S., Li, D., Wu, Y., Zhang, X., Liu, J., Song, J., Liu, L., Qu, J., & Cheng, Z. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00140 · Cited by 181

Precise In Vivo Inflammation Imaging Using In Situ Responsive Cross‐linking of Glutathione‐Modified Ultra‐Small NIR‐II Lanthanide Nanoparticles

Zhao, M., Wang, R., Li, B., Fan, Y., Wu, Y., Zhu, X., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201812878 · Cited by 171

High‐Resolution 3D NIR‐II Photoacoustic Imaging of Cerebral and Tumor Vasculatures Using Conjugated Polymer Nanoparticles as Contrast Agent

Guo, B., Chen, J., Chen, N., Middha, E., Xu, S., Pan, Y., Wu, M., Li, K., Liu, C., & Liu, B. (2019) · Advanced Materials · doi:10.1002/adma.201808355 · Cited by 159

Fluorinated conjugated polymers in organic bulk heterojunction photovoltaic solar cells

Meyer, F. (2015) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.04.007 · Cited by 131

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near‐Infrared Region

Hong, G., Robinson, J. T., Zhang, Y., Diao, S., Antaris, A. L., Wang, Q., & Dai, H. (2012) · Angewandte Chemie · doi:10.1002/ange.201206059 · Cited by 128

Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging

Ke, C.-S., Fang, C.-C., Yan, J.-Y., Tseng, P.-J., Pyle, J. R., Chen, C.-P., Lin, S.-Y., Chen, J., Zhang, X., & Chan, Y. (2017) · ACS Nano · doi:10.1021/acsnano.7b00215 · Cited by 126

Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm

Diao, S., Blackburn, J. L., Hong, G., Antaris, A. L., Chang, J., Wu, J. Z., Zhang, B., Cheng, K., Kuo, C. J., & Dai, H. (2015) · Angewandte Chemie · doi:10.1002/ange.201507473 · Cited by 122

NIR‐II Excitable Conjugated Polymer Dots with Bright NIR‐I Emission for Deep In Vivo Two‐Photon Brain Imaging Through Intact Skull

Wang, S., Liu, J., Feng, G., Ng, L. G., & Liu, B. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201808365 · Cited by 110

Theoretical studies on the photophysical properties of luminescent pincer gold( iii ) arylacetylide complexes: the role of π-conjugation at the C-deprotonated [C^N^C] ligand

Tong, G. S. M., Chan, K. T., Chang, X., & Che, C. (2015) · Chemical Science · doi:10.1039/c4sc03697b · Cited by 98

Stark fluoreszierende halbleitende Polymerpunkte für Biologie und Medizin

Wu, C., & Chiu, D. T. (2013) · Angewandte Chemie · doi:10.1002/ange.201205133 · Cited by 87

Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo

Yang, Z., Chen, J., Yao, J., Lin, R., Meng, J., Liu, C., Yang, J., Li, X., Wang, L. V., & Song, L. (2014) · Optics Express · doi:10.1364/oe.22.001500 · Cited by 78

Semiconducting polymer dots with bright narrow-band emission at 800 nm for biological applications

Chen, D., Wu, I.-C., Liu, Z., Tang, Y., Chen, H., Yu, J., Wu, C., & Chiu, D. T. (2017) · Chemical Science · doi:10.1039/c7sc00441a · Cited by 78

Controlling Ambipolar Charge Transport in Isoindigo‐Based Conjugated Polymers by Altering Fluorine Substitution Position for High‐Performance Organic Field‐Effect Transistors

Kim, M., Park, W., Park, S. A., Park, C., Ryu, S. U., Lee, D. H., Noh, Y., & Park, T. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201805994 · Cited by 65

Quinoxaline-Based Semiconducting Polymer Dots for in Vivo NIR-II Fluorescence Imaging

Liu, Y., Liu, J., Chen, D., Wang, X., Liu, Z., Liu, H., Jiang, L., Wu, C., & Zou, Y. (2019) · Macromolecules · doi:10.1021/acs.macromol.9b01142 · Cited by 65

Morphology control of planar heterojunction perovskite solar cells with fluorinated PDI films as organic electron transport layer

Huang, J.-C., Gu, Z., Zuo, L., Ye, T., & Chen, H. (2016) · Solar Energy · doi:10.1016/j.solener.2016.04.017 · Cited by 58

Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting

Wu, C., Hansen, S. J., Hou, Q., Yu, J., Zeigler, M. B., Jin, Y., Burnham, D. R., McNeill, J., Olson, J. M., & Chiu, D. T. (2011) · Angewandte Chemie · doi:10.1002/ange.201007461 · Cited by 56

Perspective: Optical spectroscopy in π -conjugated polymers and how it can be used to determine multiscale polymer structures

Barford, W., & Marcus, M. (2017) · The Journal of Chemical Physics · doi:10.1063/1.4979495 · Cited by 54

Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

Jiang, L., Bai, H., Liu, L., Lv, F., Ren, X., & Wang, S. (2019) · Angewandte Chemie · doi:10.1002/ange.201905884 · Cited by 51

Highly luminescent, fluorinated semiconducting polymer dots for cellular imaging and analysis

Zhang, Y., Yu, J., Gallina, M. E., Sun, W., Rong, Y., & Chiu, D. T. (2013) · Chemical Communications · doi:10.1039/c3cc44048f · Cited by 48

Low Internal Reorganization Energy of the Metal–Metal-to-Ligand Charge Transfer Emission in Dimeric Pt(II) Complexes

Chen, W.-C., Chou, P., & Cheng, Y. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b00224 · Cited by 47

Tm3+‐Sensitized NIR‐II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding

Zhang, H., Fan, Y., Pei, P., Sun, C., Lu, L., & Zhang, F. (2019) · Angewandte Chemie · doi:10.1002/ange.201903536 · Cited by 46

Precise In Vivo Inflammation Imaging Using In Situ Responsive Cross‐linking of Glutathione‐Modified Ultra‐Small NIR‐II Lanthanide Nanoparticles

Zhao, M., Wang, R., Li, B., Fan, Y., Wu, Y., Zhu, X., & Zhang, F. (2018) · Angewandte Chemie · doi:10.1002/ange.201812878 · Cited by 46

Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201914397 · Cited by 40

Improving the Electrical Connection of n-Type Conjugated Polymers through Fluorine-Induced Robust Aggregation

Kim, M., Park, W., Ryu, S. U., Son, S. Y., Lee, J., Shin, T. J., Noh, Y., & Park, T. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b01469 · Cited by 32

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 547

The Current Status of Photodynamic Therapy in Cancer Treatment

Jiang, W., Liang, M., Lei, Q., Li, G., & Wu, S. (2023) · Cancers · doi:10.3390/cancers15030585 · Cited by 287

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep‐Seated Tumors

Bian, H., Ma, D., Zhang, X., Xin, K., Yang, Y., Peng, X., & Xiao, Y. (2021) · Small · doi:10.1002/smll.202100398 · Cited by 203

Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance

Ji, A., Lou, H., Qu, C., Lu, W., Hao, Y., Li, J., Wu, Y., Chang, T., Chen, H., & Cheng, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-31521-y · Cited by 183

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region

Yang, Y., Jiang, Q., & Zhang, F. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00506 · Cited by 186

Semiconducting Polymer Dots with Dual‐Enhanced NIR‐IIa Fluorescence for Through‐Skull Mouse‐Brain Imaging

Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201914397 · Cited by 40

Molecular Design of Ultrabright Semiconducting Polymer Dots with High NIR‐II Fluorescence for 3D Tumor Mapping

Li, Y., Su, S., Yang, C., Liu, M.-H., Lo, P., Chen, Y., Hsu, C., Lee, Y., Chiang, H. K., & Chan, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100993 · Cited by 38

Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Liu, M.-H., Zhang, Z., Yang, Y., & Chan, Y. (2020) · Angewandte Chemie · doi:10.1002/ange.202011914 · Cited by 10

Near-Infrared II Semiconducting Polymer Dots: Chain Packing Modulation and High-Contrast Vascular Imaging in Deep Tissues

Chen, D., Qi, W., Liu, Y., Yang, Y., Shi, T., Wang, Y., Fang, X., Wang, Y., Xi, L., & Wu, C. (2023) · ACS Nano · doi:10.1021/acsnano.3c04690 · Cited by 32

Recent Advances of NIR-II Emissive Semiconducting Polymer Dots for In Vivo Tumor Fluorescence Imaging and Theranostics

Wei, Q., Xu, D., Li, T., He, X., Wang, J., Zhao, Y., & Chen, L. (2022) · Biosensors · doi:10.3390/bios12121126 · Cited by 20