Cited by 173Luminescence and Fluorescent MaterialsQuantum Dots Synthesis And PropertiesNanoplatforms for cancer theranostics

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Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

Liu, Ye, Liu, Jinfeng, Chen, Dandan, Wang, Xiaosha, Zhang, Zhe, Yang, Yicheng, Jiang, Lihui, Qi, Weizhi, Ye, Ziyuan, He, Shuqing, Liu, Quanying, Xi, Lei, Zou, Yingping, Wu, Changfeng·2020·Angewandte Chemie International Edition

DOI 10.1002/anie.202007886

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Abstract

Here, we describe a fluorination strategy for semiconducting polymers for the development of highly bright second near‐infrared region (NIR‐II) probes. Tetrafluorination yielded a fluorescence QY of 3.2 % for the polymer dots (Pdots), over a 3‐fold enhancement compared to non‐fluorinated counterparts. The fluorescence enhancement was attributable to a nanoscale fluorous effect in the Pdots that maintained the molecular planarity and minimized the structure distortion between the excited state and ground state, thus reducing the nonradiative relaxations. By performing through‐skull and through‐scalp imaging of the brain vasculature of live mice, we quantitatively analyzed the vascular morphology of transgenic brain tumors in terms of the vessel lengths, vessel branches, and vessel symmetry, which showed statistically significant differences from the wild type animals. The bright NIR‐II Pdots obtained through fluorination chemistry provide insightful information for precise diagnosis of the malignancy of the brain tumor.

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The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675
Aggregation-induced emission: phenomenon, mechanism and applications
Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2009) · Chemical Communications · doi:10.1039/b904665h · Cited by 4,153
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Organic fluorine compounds: a great opportunity for enhanced materials properties
Berger, R., Resnati, G., Metrangolo, P., Weber, E., & Hulliger, J. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00221f · Cited by 1,520
Multifunctional nanoparticles for multimodal imaging and theragnosis
Lee, D., Koo, H., Sun, I., Ryu, J. H., Kim, K., & Kwon, I. C. (2011) · Chemical Society Reviews · doi:10.1039/c2cs15261d · Cited by 1,433
Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine
Wu, C., & Chiu, D. T. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201205133 · Cited by 1,111
Self-citation
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,084
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052
Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications
Feng, L., Zhu, C., Yuan, H., Liu, L., Lv, F., & Wang, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60036j · Cited by 873

Show all 62 references

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Authors: Liu, Y., Liu, J., Chen, D., Wang, X., Zhang, Z., Yang, Y., Jiang, L., Qi, W., Ye, Z., He, S., Liu, Q., Xi, L., Zou, Y., & Wu, C.
Affiliations: Central South University (CN)
Southern University of Science and Technology (CN)
Corresponding author: Zou, Yingping
Wu, Changfeng
ORCID: Liu, Ye
Liu, Jinfeng
Chen, Dandan
Zhang, Zhe
Yang, Yicheng
Jiang, Lihui
Ye, Ziyuan
He, Shuqing
Liu, Quanying
Xi, Lei
Zou, Yingping
Wu, Changfeng
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2020-09-08
Volume: 59
Issue: 47
Pages: 21049-21057
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.202007886
OpenAlex: W3047818792
Cited by: 173
References: 62
Citations by year: 2026: 12 · 2025: 24 · 2024: 29 · 2023: 39 · 2022: 36 · 2021: 29 · 2020: 4
FWCI: 10.50
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Funders: Science, Technology and Innovation Commission of Shenzhen Municipality (KQTD20170810111314625)
National Natural Science Foundation of China (81771930, 51673215)
National Basic Research Program of China (2018YFB0407200)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: fluorination, polymer dots, NIR-II fluorescence, semiconducting polymers, fluorescence quantum yield enhancement, brain tumor imaging, cerebral vasculature, transgenic mouse model
MeSH terms: Animals, Brain Neoplasms, Fluorescence, Fluorescent Dyes, Mice, Inbred C57BL, Particle Size, Polymers, Semiconductors, Surface Properties, Molecular Structure, Quantum Dots, Mice, Halogenation, Optical Imaging

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Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

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