Nano‐enabled poly (vinyl alcohol) based injectable bio‐nanocomposite hydrogel scaffolds
Abstract
ABSTRACT We report development of poly(vinyl alcohol) (PVA)‐based novel injectable hydrogel nanocomposite scaffolds. Nanocellulose (NC), synthesized from agricultural biomass, was used as reinforcement within PVA matrix. The hydrogels were formed using physical crosslinking process involving multiple freeze–thaw cycles. A range of bio‐nanocomposite hydrogels were prepared with varying concentrations of NC. With increasing loading of NC, crystallinity was found to be increased, which could be attributed to nucleating effect and crystalline nature of nanofibrillar cellulose. Investigation of microstructural surface topology indicated reduced surface perturbations upon incorporation of NC. Fourier transform infrared spectroscopy studies further indicated presence of characteristic functional groups and possible interactions between PVA and NC. Enhanced structural integrity and dynamic stability of the bio‐nanocomposite hydrogels were also confirmed by carrying out rheological investigations at different frequency, amplitude, temperature, and time sweeps. Further, the bio‐nanocomposite hydrogels demonstrated excellent injectability and self‐standing behavior, establishing the promising potential as injectable scaffolds. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48789.
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The compressive modulus of the scaffold tends to improve when HA is introduced into the collagen matrix.
“It was reported that the compressive modulus of the scaffold tends to improve when HA is introduced into the collagen matrix [54].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [54]
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57 · see citing works
- Authors
- Phogat, K., Kanwar, S., Nayak, D., Mathur, N., Ghosh, S. B., & Bandyopadhyay‐Ghosh, S.
- Affiliations
- JECRC University (IN)
- Manipal University Jaipur (IN)
- Corresponding author
- Bandyopadhyay‐Ghosh, Sanchita
- Venue
- Journal of Applied Polymer Science
- Publisher
- Wiley
- Published
- 2019-12-18
- Volume
- 137
- Issue
- 23
- ISSN
- 0021-8995 (ISSN-L)
- 1097-4628
- OpenAlex
- W2995320544
- Cited by
- 41
- References
- 32
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 14 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Polymer Science (publishedVersion)
- Funders
- Manipal University Jaipur (EF/2017-18/QE04-07)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- polyvinyl alcohol, injectable hydrogel, nanocellulose, freeze-thaw crosslinking, crystallinity, nucleation, rheological stability, injectability, agricultural biomass
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