The Matrisome, Inflammation, and Liver Disease
Open accessAbstract
Chronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM) proteins (collagens) that ultimately impairs the function of the organ. The role of the ECM in early stages of chronic liver disease is less well-understood, but recent research has demonstrated that several changes in the hepatic ECM in prefibrotic liver disease are not only present but may also contribute to disease progression. The purpose of this review is to summarize the established and proposed changes to the hepatic ECM that may contribute to inflammation during earlier stages of disease development, and to discuss potential mechanisms by which these changes may mediate the progression of the disease.
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Changes in the matrisome affect all ECM molecule families and alter the biochemical and mechanical properties of the liver.
“Progressive changes in the composition of the matrisome affect all families of ECM molecules (17, 18), leading to altered biochemical and mechanical features of the liver.”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [17]
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Flagged first, then by citations
Research works printed but not linked: 1
- [5]Friedman SL. Extracellular matrix In: Dufour JF, Clavien PA, eds. Signaling Pathways in Liver Diseases. Berlin: Springer; 2010: 93– 104
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Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
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- Authors
- Dolin, C. E., & Arteel, G. E.
- Affiliations
- University of Louisville (US)
- University of Pittsburgh (US)
- Corresponding author
- Arteel, Gavin E.
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2020-01-07
- Volume
- 40
- Issue
- 02
- Pages
- 180-188
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- PMC
- PMC7195244
- OpenAlex
- W3000114186
- Cited by
- 38
- References
- 135
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 1
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA021978)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK120531)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- matrisome, extracellular matrix, liver inflammation, liver fibrosis, liver cirrhosis, collagen deposition, steatosis, disease progression
- MeSH terms
- Humans, Inflammation, Liver Diseases, Extracellular Matrix Proteins, Disease Progression
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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