Cited by 506Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task Force at the 13th International Congress on antiphospholipid antibodies

Open access
Ruiz-Irastorza, G, Cuadrado, MJ, Ruiz-Arruza, I, Brey, R, Crowther, M, Derksen, R, Erkan, D, Krilis, S +5 more·2011·Lupus

Abstract

The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid antibodies: lupus anticoagulant, anticardiolipin antibodies and/or anti-β2-glycoprotein I antibodies in medium to high titers. The management of thrombosis in patients with APS is a subject of controversy. This set of recommendations is the result of an effort to produce guidelines for therapy within a group of specialist physicians in Cardiology, Neurology, Hematology, Rheumatology and Internal Medicine, with a clinical and research focus on APS.

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Crossref · 10.1177/0961203310395803

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76 of 76 references verified0 citation errors · 0 not checkable

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  • A high-risk antiphospholipid antibody profile is associated with a greater risk of thrombotic and obstetric antiphospholipid syndrome.

    “High-risk antiphospholipid antibody (aPL) profile is associated with greater risk for thrombotic and obstetric APS.”
  • The presence of antiphospholipid antibodies in asymptomatic individuals or in patients with systemic lupus erythematosus does not confirm antiphospholipid syndrome, but it can be associated with increased risk of thrombosis or pregnancy morbidity depending on antibody characteristics and other risk factors.

    “The presence of aPL in asymptomatic individuals or patients with SLE does not confirm the diagnosis of APS but can be associated with increased risk of thrombosis or pregnancy morbidity, depending on aPL characteristics and coexistence of other risk factors.3 4”

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Authors
Ruiz-Irastorza, G., Cuadrado, M., Ruiz-Arruza, I., Brey, R., Crowther, M., Derksen, R., Erkan, D., Krilis, S., Machin, S., Pengo, V, Pierangeli, S., Tektonidou, M., & Khamashta, M.
Affiliations
  • Autoimmune Disease Research Unit, Department of Internal Medicine, Hospital de Cruces, University of the Basque Country, Barakaldo, Spain
  • King's College London (GB)
  • The University of Texas at San Antonio Health Science Center (US)
  • McMaster University (CA)
  • University Medical Center Utrecht (NL)
  • Hospital for Special Surgery (US)
  • UNSW Sydney (AU)
  • University College London (GB)
  • University of Padua (IT)
  • The University of Texas Medical Branch at Galveston (US)
  • National and Kapodistrian University of Athens (GR)
Venue
Lupus
Published
2011-02
Volume
20
Issue
2
Pages
206-218
ISSN
  • 0961-2033 (ISSN-L)
  • 1477-0962
OpenAlex
W2132103149
Cited by
506
References
76
Citations by year
2026: 7 · 2025: 10 · 2024: 15 · 2023: 17 · 2022: 24 · 2021: 28 · 2020: 41 · 2019: 54 · 2018: 46 · 2017: 42 · 2016: 38 · 2015: 48 · 2014: 39 · 2013: 47 · 2012: 32
FWCI
30.75
Type
journal article
Language
en
Open access
Locations
  • Lupus (publishedVersion)
  • PubMed (publishedVersion)
  • DSpace - NTUA (National Technical University of Athens) (submittedVersion, other-oa)
  • Research Portal (King's College London) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
Keywords
antiphospholipid syndrome, thromboprophylaxis, antiphospholipid antibodies, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, lupus anticoagulant, long-term anticoagulation, pregnancy morbidity
MeSH terms
Clinical Trials as Topic, Congresses as Topic, Female, Humans, Pregnancy, Texas, Thrombosis, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Advisory Committees

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