The association between circulating antibodies against domain I of beta2‐glycoprotein I and thrombosis: an international multicenter study
Open accessAbstract
Background Diagnosis of the antiphospholipid syndrome (APS) is difficult as a result of limited specificity of existing assays for detecting clinically relevant antiphospholipid antibodies. Anti-beta2-glycoprotein I (beta 2GPI) antibodies play a central role in the disease process of APS.Objectives We have investigated the relation between antiphospholipid antibodies with specificity for domain I of beta 2GPI and thrombosis/pregnancy morbidity in an international multicenter study.Patients/methods Four hundred and seventy-seven patients derived from nine different centres met the inclusion criterion of having anti-beta 2GPI antibodies in their plasma/serum. Clinical data and results of tests for lupus anticoagulant, anti-cardiolipin antibodies and anti-beta 2GPI antibodies were established at the different centres of inclusion. After being re-tested for the presence of IgG and/or IgM anti-beta 2GPI antibodies, the samples were tested for the presence of IgG-directed against domain I of beta 2GPI and results were correlated with the thrombotic and obstetric history.Results Re-testing for the presence of anti-beta 2GPI antibodies resulted in inclusion of 442/477 patients. IgG class anti-domain I antibodies were present in plasma of 243/442 patients (55%). 201/243 (83%) had a history of thrombosis. This resulted in an odds ratio of 3.5 (2.3-5.4, 95% confidence interval) for thrombosis. Anti-domain I IgG antibodies were also significantly correlated with obstetric complications [odds ratio: 2.4 (1.4-4.3, 95% confidence interval)].Conclusion In this multicenter study, the detection of IgG antibodies that are directed against domain I of beta 2GPI proved to be more strongly associated with thrombosis and obstetric complications than those detected using the standard anti-beta 2GPI antibody assay.
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These results confirm and validate several previous reports that have implicated these antibodies in the pathogenesis of APS.
“These results confirm and validate several previous reports that have implicated these antibodies in the pathogenesis of APS [9, 10, 12, 13, 29, 30], but they also add to the growing body of evidence that shows inconsistent associations between aPL-associated autoantibodies and anamnestic thrombotic risk [3, 16].”
From Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant (2017) · cites this paper as [12]
Cites
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519 · see citing works
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works
Cervera, R., Piette, J., Font, J., Khamashta, M. A., Shoenfeld, Y., Camps, M. T., Jacobsen, S., Lakos, G., Tincani, A., Kontopoulou‐Griva, I., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10187 · Cited by 2,156 · see citing works
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-02-0441 · Cited by 974 · see citing works
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-11-3334 · Cited by 413 · see citing works
de Laat, B., Derksen, R. H. W. M., Urbanus, R. T., & de Groot, P. G. (2005) · Blood · doi:10.1182/blood-2004-09-3387 · Cited by 378 · see citing works
Self-citationAntibody profiles for the diagnosis of antiphospholipid syndrome
Biasiolo, A., Pegoraro, C., Cucchini, U., Noventa, F., Iliceto, S., & Pengo, V. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-12-0839 · Cited by 318 · see citing works
Self-citationAnti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI
Iverson, G. M., Victoria, E. J., & Marquis, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15542 · Cited by 232 · see citing works
de Laat, H. B., Derksen, R. H. W. M., Urbanus, R. T., Roest, M., & de Groot, P. G. (2004) · Blood · doi:10.1182/blood-2004-03-1107 · Cited by 219 · see citing works
Self-citationAutoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly
Ramos‐Casals, M., García‐Carrasco, M., Brito, M. P., López‐Soto, A., & Font, J. (2003) · Lupus · doi:10.1191/0961203303lu383ed · Cited by 146 · see citing works
Ioannou, Y., Pericleous, C., Giles, I., Latchman, D. S., Isenberg, D. A., & Rahman, A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22306 · Cited by 131 · see citing works
Mechanisms of Disease: antiphospholipid antibodies—from clinical association to pathologic mechanism
de Laat, B., Mertens, K., & de Groot, P. G. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0740 · Cited by 90 · see citing works
Self-citationInvitation to a debate on the serological criteria that define the antiphospholipid syndrome
GALLI, M., REBER, G., DE MOERLOOSE, P., & DE GROOT, P. G. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.02862.x · Cited by 85 · see citing works
Self-citationLaboratory Testing for Lupus Anticoagulants: A Review of Issues Affecting Results
Tripodi, A. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.089524 · Cited by 81 · see citing works
抗β2糖蛋白質I(β2GPI)自己抗体はβ2GPIの第一ドメイン上のエピトープを認識する
Iverson, G. M., Victoria, E. J., & M, M. D. (1998) · Cited by 61 · see citing works
McNeeley, P. A., Dlott, J. S., Furie, R. A., et al. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616091 · Cited by 60 · see citing works
High prevalence of autoantibodies among Danish centenarians
Andersen‐Ranberg, K., Høier‐Madsen, M., Wiik, A. S., Jeune, B., & Hegedűs, L. D. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02575.x · Cited by 60 · see citing works
Yu, P., Passam, F. H., Yu, D. M., et al. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03000.x · Cited by 48 · see citing works
Anti-beta 2 glycoprotein I antibodies in centenarians
Meroni, P. L., Mari, D., Monti, D., Coppola, R., Capri, M., Salvioli, S., Tincani, A., Gerli, R., & Franceschi, C. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.08.003 · Cited by 48 · see citing works
Clinical Features, Diagnosis, and Management of the Antiphospholipid Syndrome
Wong, R. C. W., & Favaloro, E. J. (2008) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0028-1082275 · Cited by 38 · see citing works
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Pathogenesis of antiphospholipid syndrome: understanding the antibodies
Meroni, P. L., Borghi, M. O., Raschi, E., & Tedesco, F. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.52 · Cited by 620 · see citing works
Ruiz-Irastorza, G., Cuadrado, M., Ruiz-Arruza, I., Brey, R., Crowther, M., Derksen, R., Erkan, D., Krilis, S., Machin, S., Pengo, V, et al. (2011) · Lupus · doi:10.1177/0961203310395803 · Cited by 506 · see citing works
Self-citationLaboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH
Devreese, K. M. J., Ortel, T. L., Pengo, V., & de Laat, B. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13976 · Cited by 269 · see citing works
Self-citationTesting for Antiphospholipid antibodies with Solid Phase Assays: guidance from the SSC of the ISTH
Devreese, K. M. J., Pierangeli, S. S., de Laat, B., Tripodi, A., Atsumi, T., & Ortel, T. L. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12537 · Cited by 224 · see citing works
Self-citationPengo, V., Ruffatti, A., Tonello, M., Cuffaro, S., Banzato, A., Bison, E., Denas, G., & Padayattil Jose, S. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12865 · Cited by 126 · see citing works
Self-citationAntiphospholipid antibody testing and standardization
Devreese, K. M. J. (2014) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12234 · Cited by 98 · see citing works
The antiphospholipid syndrome: still an enigma
Chaturvedi, S., & McCrae, K. R. (2015) · Hematology · doi:10.1182/asheducation-2015.1.53 · Cited by 51 · see citing works
Pengo, V., Ruffatti, A., Tonello, M., Hoxha, A., Bison, E., Denas, G., Padayattil Jose, S., Zoppellaro, G., Bracco, A., & Banzato, A. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2015.04.031 · Cited by 47 · see citing works
Self-citationPosch, F., Gebhart, J., Rand, J. H., Koder, S., Quehenberger, P., Pengo, V., Ay, C., & Pabinger, I. (2017) · BMC Medicine · doi:10.1186/s12916-017-0807-7 · Cited by 25 · see citing works
“Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, de Groot PG, Koike T, Meroni PL, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS).”
ResultInfluentialSelf-citation
- Authors
- DE LAAT, B., PENGO, V., PABINGER, I., MUSIAL, J., VOSKUYL, A. E., BULTINK, I. E. M., RUFFATTI, A., ROZMAN, B., KVEDER, T., DE MOERLOOSE, P., BOEHLEN, F., RAND, J., ULCOVA‐GALLOVA, Z., MERTENS, K., & DE GROOT, P. G.
- Affiliations
- University of Padua (IT)
- University of Vienna (AT)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Ljubljana University Medical Centre (SI)
- University Hospital of Geneva (CH)
- Sanquin (NL)
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 7
- Issue
- 11
- Pages
- 1767-1773
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W2101326680
- Cited by
- 291
- References
- 20
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 19 · 2018: 23 · 2017: 26 · 2016: 24 · 2015: 18 · 2014: 21 · 2013: 22 · 2012: 25
- FWCI
- 17.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, beta2-glycoprotein I, anti-beta2-glycoprotein I antibodies, thrombosis, pregnancy morbidity, pregnancy complications, lupus anticoagulant, anticardiolipin antibodies, IgG
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Epitopes, Autoantibodies, Female, Humans, Immunoglobulin G, Male, Middle Aged, Pregnancy, Pregnancy Complications, Thrombosis, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, beta 2-Glycoprotein I, Young Adult
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