The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Tissue‐engineered composites for the repair of large osteochondral defects
Abstract
Objective: To test the hypothesis that engineered cartilage can provide a mechanically functional template capable of undergoing orderly remodeling during the repair of large osteochondral defects in adult rabbits, as assessed by quantitative structural and functional methods. Methods: Engineered cartilage generated in vitro from chondrocytes cultured on a biodegradable scaffold was sutured to a subchondral support and the resulting composite press‐fitted into a 7‐mm long, 5‐mm wide, 5‐mm deep osteochondral defect in a rabbit knee joint. Defects left empty (group 1) or treated with cell‐free composites (group 2) served as controls for defects treated with composites of engineered cartilage and the support, without or with adsorbed bone marrow (groups 3 and 4, respectively). Results: Engineered cartilage withstood physiologic loading and remodeled over 6 months into osteochondral tissue with characteristic architectural features and physiologic Young's moduli. Composites integrated well with host bone in 90% of cases but did not integrate well with host cartilage. Structurally, 6‐month repairs in groups 3 and 4 were superior to those in group 2 with respect to histologic score, cartilage thickness, and thickness uniformity, but were inferior to those in unoperated control tissue. At 6 months, Young's moduli in groups 2, 3, and 4 (0.68, 0.80, and 0.79 MPa, respectively) approached that in unoperated control tissue (0.84 MPa), whereas the corresponding modulus in group 1 (0.37 MPa) was significantly lower. Conclusion: Composites of tissue‐engineered cartilage and a subchondral support promote the orderly remodeling of large osteochondral defects in adult rabbits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Woessner, J. F. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90291-0 · Cited by 3,840
FARNDALE, R., BUTTLE, D., & BARRETT, A. (1986) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(86)90306-5 · Cited by 3,312
Biodegradable Polymer Scaffolds for Tissue Engineering
Freed, L. E., Vunjak-Novakovic, G., Biron, R. J., Eagles, D. B., Lesnoy, D. C., Barlow, S. K., & Langer, R. (1994) · Nature Biotechnology · doi:10.1038/nbt0794-689 · Cited by 1,235
Self-citationA mathematical analysis for indentation tests of articular cartilage
Hayes, W. C., Keer, L. M., Herrmann, G., & Mockros, L. F. (1972) · Journal of Biomechanics · doi:10.1016/0021-9290(72)90010-3 · Cited by 967
Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage
Athanasiou, K. A., Rosenwasser, M. P., Buckwalter, J. A., Malinin, T. I., & Mow, V. C. (1991) · Journal of Orthopaedic Research · doi:10.1002/jor.1100090304 · Cited by 750
Vunjak‐Novakovic, G., Martin, I., Obradovic, B., Treppo, S., Grodzinsky, A. J., Langer, R., & Freed, L. E. (1999) · Journal of Orthopaedic Research · doi:10.1002/jor.1100170119 · Cited by 743
Self-citationCurrent Concepts Review - The Healing and Regeneration of Articular Cartilage*
OʼDRISCOLL, S. W. (1998) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199812000-00011 · Cited by 629
HUNZIKER, E. B., & ROSENBERG, L. C. (1996) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199605000-00012 · Cited by 616
Frazza, E. J., & Schmitt, E. E. (1971) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820050207 · Cited by 572
OʼDriscoll, S. W., Keeley, F. W., & Salter, R. B. (1986) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-198668070-00008 · Cited by 520
Cited by
Chung, C., & Burdick, J. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.027 · Cited by 760
Biomaterials for articular cartilage tissue engineering: Learning from biology
Armiento, A. R., Stoddart, M. J., Alini, M., & Eglin, D. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.021 · Cited by 579
Tissue engineering and cell therapy of cartilage and bone
Cancedda, R., Dozin, B., Giannoni, P., & Quarto, R. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00012-x · Cited by 512
Oliveira, J. M., Rodrigues, M. T., Silva, S. S., Malafaya, P. B., Gomes, M. E., Viegas, C. A., Dias, I. R., Azevedo, J. T., Mano, J. F., & Reis, R. L. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.07.034 · Cited by 448
Fedorovich, N. E., Schuurman, W., Wijnberg, H. M., Prins, H.-J., van Weeren, P. R., Malda, J., Alblas, J., & Dhert, W. J. A. (2012) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2011.0060 · Cited by 403
Metadata
- Authors
- Schaefer, D., Martin, I., Jundt, G., Seidel, J., Heberer, M., Grodzinsky, A., Bergin, I., Vunjak‐Novakovic, G., & Freed, L. E.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2002-09
- Volume
- 46
- Issue
- 9
- Pages
- 2524-2534
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1986867932
- Cited by
- 311
- References
- 24
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tissue‐engineered composites for the repair of large osteochondral defects. https://app.cochat.ai/papers/10.1002/art.10493
- The paper
- Schaefer, D., Martin, I., Jundt, G., Seidel, J., Heberer, M., Grodzinsky, A., Bergin, I., Vunjak‐Novakovic, G., & Freed, L. E. (2002). Tissue‐engineered composites for the repair of large osteochondral defects. Arthritis & Rheumatism. https://doi.org/10.1002/art.10493
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
