The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Biofabrication of Osteochondral Tissue Equivalents by Printing Topologically Defined, Cell-Laden Hydrogel Scaffolds
Open accessAbstract
Osteochondral defects are prone to induce osteoarthritic degenerative changes. Many tissue-engineering approaches that aim to generate osteochondral implants suffer from poor tissue formation and compromised integration. This illustrates the need for further improvement of heterogeneous tissue constructs. Engineering of these structures is expected to profit from strategies addressing the complexity of tissue organization and the simultaneous use of multiple cell types. Moreover, this enables the investigation of the effects of three-dimensional (3D) organization and architecture on tissue function. In the present study, we characterize the use of a 3D fiber deposition (3DF) technique for the fabrication of cell-laden, heterogeneous hydrogel constructs for potential use as osteochondral grafts. Changing fiber spacing or angle of fiber deposition yielded scaffolds of varying porosity and elastic modulus. We encapsulated and printed fluorescently labeled human chondrocytes and osteogenic progenitors in alginate hydrogel yielding scaffolds of 1×2 cm with different parts for both cell types. Cell viability remained high throughout the printing process, and cells remained in their compartment of the printed scaffold for the whole culture period. Moreover, distinctive tissue formation was observed, both in vitro after 3 weeks and in vivo (6 weeks subcutaneously in immunodeficient mice), at different locations within one construct. These results demonstrate the possibility of manufacturing viable centimeter-scaled structured tissues by the 3DF technique, which could potentially be used for the repair of osteochondral defects.
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Cited by
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
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25th Anniversary Article: Engineering Hydrogels for Biofabrication
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3D Printing of Scaffolds for Tissue Regeneration Applications
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Metadata
- Authors
- Fedorovich, N. E., Schuurman, W., Wijnberg, H. M., Prins, H.-J., van Weeren, P. R., Malda, J., Alblas, J., & Dhert, W. J. A.
- Venue
- Tissue Engineering Part C: Methods
- Publisher
- SAGE Publications
- Published
- 2012-01
- Volume
- 18
- Issue
- 1
- Pages
- 33-44
- ISSN
- 1937-3384 (ISSN-L)
- 1937-3392
- OpenAlex
- W1491824752
- Cited by
- 403
- References
- 46
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Fedorovich, N. E., Schuurman, W., Wijnberg, H. M., Prins, H.-J., van Weeren, P. R., Malda, J., Alblas, J., & Dhert, W. J. A. (2012). Biofabrication of Osteochondral Tissue Equivalents by Printing Topologically Defined, Cell-Laden Hydrogel Scaffolds. Tissue Engineering Part C: Methods. https://doi.org/10.1089/ten.tec.2011.0060
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