The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes
Abstract
Objective: Osteoarthritis (OA) is a degenerative rheumatic disease that is associated with extracellular matrix degradation and chondrocyte apoptosis in the articular cartilage. The role of mitochondria in degenerative diseases is widely recognized. We undertook this study to evaluate mitochondrial function in normal and OA chondrocytes and to examine age‐related changes in mitochondria. Methods: Mitochondrial function was evaluated by analyzing respiratory chain enzyme complexes and citrate synthase (CS) activities as well as changes in mitochondrial membrane potential (ΔΨm). The activities of mitochondrial respiratory chain complexes (complex I: rotenone‐sensitive NADH–coenzyme Q 1 reductase; complex II: succinate dehydrogenase; complex III: antimycin‐sensitive ubiquinol cytochrome c reductase; and complex IV: cytochrome c oxidase) and CS were measured in human articular chondrocytes isolated from OA and normal cartilage. ΔΨm was measured by JC‐1 using flow cytometry. Statistical analysis was performed using the Mann‐Whitney U test and Student's t‐test as well as several models of multiple linear regression. Results: OA articular chondrocytes had reduced activities of complexes II and III compared with cells from normal cartilage. However, the mitochondrial mass was increased in OA. Cultures of OA chondrocytes contained a higher proportion of cells with de‐energized mitochondria. We found no relationship between mitochondrial function and donor age either in normal or in OA chondrocytes. Conclusion: These findings suggest the involvement of mitochondrial function in the pathophysiology of OA. Cartilage degradation by OA and cartilage aging may be two different processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,965
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Kluck, R. M., Bossy-Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,714
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Mitochondrial control of apoptosis
Kroemer, G., Zamzami, N., & Susin, S. A. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80014-x · Cited by 1,471
Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241
Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.5.1661 · Cited by 1,166
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730
Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology
Blanco, F. J., Guitian, R., V�zquez-Martul, E., de Toro, F. J., & Galdo, F. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199802)41:2<284::aid-art12>3.0.co;2-t · Cited by 604
Self-citationPetit, P. X., Lecoeur, H., Zorn, E., Dauguet, C., Mignotte, B., & Gougeon, M. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.130.1.157 · Cited by 592
Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
LEE, H.-C., YIN, P.-H., LU, C.-Y., CHI, C.-W., & WEI, Y.-H. (2000) · Biochemical Journal · doi:10.1042/bj3480425 · Cited by 551
Cited by
Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
Hwang, H., & Kim, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125943 · Cited by 886
van der Heijde, D., Kivitz, A., Schiff, M. H., Sieper, J., Dijkmans, B. A. C., Braun, J., Dougados, M., Reveille, J. D., Wong, R. L., Kupper, H., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21913 · Cited by 872
ROS/oxidative stress signaling in osteoarthritis
Lepetsos, P., & Papavassiliou, A. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.003 · Cited by 801
The role of metabolism in the pathogenesis of osteoarthritis
Mobasheri, A., Rayman, M. P., Gualillo, O., Sellam, J., van der Kraan, P., & Fearon, U. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.50 · Cited by 742
Results after microfracture of full-thickness chondral defects in different compartments in the knee
Kreuz, P. C., Steinwachs, M. R., Erggelet, C., Krause, S. J., Konrad, G., Uhl, M., & Südkamp, N. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.05.003 · Cited by 732
Metadata
- Authors
- Maneiro, E., Martín, M. A., de Andres, M. C., López‐Armada, M. J., Fernández‐Sueiro, J. L., del Hoyo, P., Galdo, F., Arenas, J., & Blanco, F. J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2003-02-28
- Volume
- 48
- Issue
- 3
- Pages
- 700-708
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2075978331
- Cited by
- 262
- References
- 43
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes. https://app.cochat.ai/papers/10.1002/art.10837
- The paper
- Maneiro, E., Martín, M. A., de Andres, M. C., López‐Armada, M. J., Fernández‐Sueiro, J. L., del Hoyo, P., Galdo, F., Arenas, J., & Blanco, F. J. (2003). Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes. Arthritis & Rheumatism. https://doi.org/10.1002/art.10837
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
