Cited by 337Stress Responses and CortisolAdrenal Hormones and DisordersRheumatoid Arthritis Research and Therapies

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis

Chikanza, Ian C., Petrou, Petros, Kingsley, Gabrielle, Chrousos, George, Panayi, Gabriel S.·1992·Arthritis & Rheumatism

Open this paper in CoChat — free account

Abstract

OBJECTIVE: To determine the integrity of the hypothalamic-pituitary-adrenal (HPA) axis responses to immune/inflammatory stimuli in patients with rheumatoid arthritis (RA). METHODS: Diurnal secretion of cortisol and the cytokine and cortisol responses to surgery were studied in subjects with active RA, in subjects with chronic osteomyelitis (OM), and in subjects with noninflammatory arthritis, who served as controls. RESULTS: Patients with RA had a defective HPA response, as evidenced by a diurnal cortisol rhythm of secretion which was at the lower limit of normal in contrast to those with OM, and a failure to increase cortisol secretion following surgery, despite high levels of interleukin-1 beta (IL-1 beta) and IL-6. The corticotropin-releasing hormone stimulation test in the RA patients showed normal results, thus suggesting a hypothalamic defect, but normal pituitary and adrenal function. CONCLUSION: These findings suggest that RA patients have an abnormality of the HPA axis response to immune/inflammatory stimuli which may reside in the hypothalamus. This hypothalamic abnormality may be an additional, and hitherto unrecognized, factor in the pathogenesis of RA.

Integrity signals

Registry

Crossref · 10.1002/art.1780351107

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1958 Revision of diagnostic criteria for rheumatoid arthritis
Ropes, M. W., Bennett, G. A., Cobb, S., Jacox, R. F., & Jessar, R. A. (1959) · Arthritis & Rheumatism · doi:10.1002/1529-0131(195902)2:1 · Cited by 1,999
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis
Arend, W. P., & Dayer, J. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330302 · Cited by 957
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 755
Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723
Self-citation
A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats.
Sternberg, E. M., Young, W. S., Bernardini, R., Calogero, A. E., Chrousos, G. P., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4771 · Cited by 568
Self-citation
The Corticotropin-Releasing Factor Stimulation Test
Chrousos, G. P., Schulte, H. M., Oldfield, E. H., Gold, P. W., Cutler, G. B., & Loriaux, D. L. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403083101004 · Cited by 350
Self-citation
Interleukin 6, the third mediator of acute‐phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 β and tumor necrosis factor‐α
Ramadori, G., Van Damme, J., Rieder, H., & Zum Büschenfelde, K. M. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180817 · Cited by 284
Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease
Mason, D. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90158-p · Cited by 254
Review of Medical Physiology
Black, R. L. (1984) · Military Medicine · doi:10.1093/milmed/149.3.161a · Cited by 248

Flagged first, then by citations

Show all 35 references

Research works printed but not linked: 1

Dinarello CA, 1978, Radiolabelling and deposition in rabbits of purified human leucocyte pyrogen, Clin Res, 28, 522A

Sorted by citations

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822
Self-citation
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Self-citation
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799
Self-citation
The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.
Melamed, S., Shirom, A., Toker, S., Berliner, S., & Shapira, I. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.327 · Cited by 943
Stressors, Stress, and Neuroendocrine Integration of the Adaptive Response: The 1997 Hans Selye Memorial Lecture
Chrousos, G. P. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09006.x · Cited by 731
Self-citation
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
Crofford, L. J., Wilder, R. L., Ristimaki, A. P., Sano, H., Remmers, E. F., Epps, H. R., & Hla, T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117060 · Cited by 650
Neuroendocrine-Immune Interactions
Epstein, F. H., & Reichlin, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310213291708 · Cited by 566
The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders
Knezevic, E., Nenic, K., Milanovic, V., & Knezevic, N. N. (2023) · Cells · doi:10.3390/cells12232726 · Cited by 564
“The HPA axis output is a dynamic, oscillating glucocorticoid signal that requires decoding at the cellular level [11].”
Background
Neuroendocrinology and pathophysiology of the stress system
STRATAKIS, C. A., & CHROUSOS, G. P. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44666.x · Cited by 533
Self-citation
Dynamics of ACTH and Cortisol Secretion and Implications for Disease
Lightman, S. L., Birnie, M. T., & Conway-Campbell, B. L. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa002 · Cited by 439
Do breast‐feeding and other reproductive factors influence future risk of rheumatoid arthritis?: Results from the Nurses' Health Study
Karlson, E. W., Mandl, L. A., Hankinson, S. E., & Grodstein, F. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20621 · Cited by 400
Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders
Souza, E. B. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00011-9 · Cited by 397
Fatigue in chronic disease
Swain, M. G. (2000) · Clinical Science · doi:10.1042/cs0990001 · Cited by 384
Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network
Li, S., Zhang, Z. Q., Wu, L., Zhang, X., Li, Y. D., & Wang, Y. Y. (2007) · IET Systems Biology · doi:10.1049/iet-syb:20060032 · Cited by 369
Pediatric Stress: Hormonal Mediators and Human Development
Charmandari, E., Kino, T., Souvatzoglou, E., & Chrousos, G. P. (2003) · Hormone Research in Paediatrics · doi:10.1159/000069325 · Cited by 374
Self-citation
A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis
Baugh, J. A., Chitnis, S., Donnelly, S. C., Monteiro, J., Lin, X., Plant, B. J., Wolfe, F., Gregersen, P. K., & Bucala, R. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363867 · Cited by 360
Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome
Symmons, D. P. M. (2002) · Best Practice & Research Clinical Rheumatology · doi:10.1053/berh.2002.0257 · Cited by 319
Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis
Beishuizen, A., & THIJS, L. G. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103125001298 · Cited by 337
Abuse-Related Posttraumatic Stress Disorder and Alterations of the Hypothalamic-Pituitary-Adrenal Axis in Women With Chronic Pelvic Pain
Heim, C., Ehlert, U., Hanker, J. P., & Hellhammer, D. H. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00017 · Cited by 309
Neuroendocrine regulation of autoimmune/inflammatory disease
Sternberg, E. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690429 · Cited by 308
PREGNANCY AND RHEUMATOID ARTHRITIS
Nelson, J. L., & Østensen, M. (1997) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70323-9 · Cited by 304
Sex Hormones and Glucocorticoids: Interactions with the Immune System
da Silva, J. A. P. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07628.x · Cited by 279
Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress
Rohleder, N., Schommer, N. C., Hellhammer, D. H., Engel, R., & Kirschbaum, C. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200111000-00016 · Cited by 276
Stress, Endocrine Physiology and Pathophysiology -- Endotext
DeGroot, L. J., Chrousos, G. P., Dungan, K., Grossman, A. B., Jm, H., Koch, C., Korbonits, M., McLachlan, R., New, M., Purnell, J. Q., et al. (2000) · Europe PMC (PubMed Central) · Cited by 260
Self-citation
Development of macromolecular prodrug for rheumatoid arthritis
Fang, Y., Quan, L., Cui, L., Goldring, S. R., & Wang, D. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.006 · Cited by 242
Anti-Tumor Necrosis Factor-α Therapy of Rheumatoid Arthritis
Feldmann, M., Elliott, M. J., Maini, R. N., & Woody, J. N. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60891-3 · Cited by 224
Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Proinflammatory Cytokines in Osteoblasts: An Autocrine Switch from Glucocorticoid Inactivation to Activation
Cooper, M. S., Bujalska, I. J., Rabbitt, E. H., Walker, E. A., Bland, R., Sheppard, M. C., Hewison, M., & Stewart, P. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1037 · Cited by 229
The Chronobiology of Human Cytokine Production
Petrovsky, N., & Harrison, L. C. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043012 · Cited by 214
Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro
Visser, J. T. J., van Boxel-Dezaire, A. H. H., Methorst, D., Brunt, T. M., de Kloet, E. R., & Nagelkerken, L. M. (1998) · Blood · doi:10.1182/blood.v91.11.4255 · Cited by 205
Circadian rhythm of serum interleukin-6 in rheumatoid arthritis.
Arvidson, N. G., Guðbjörnsson, B., Elfman, L., Rydén, A. C., Tötterman, T. H., & Hällgren, R. (1994) · Annals of the Rheumatic Diseases · doi:10.1136/ard.53.8.521 · Cited by 201
Physiology of the Hypothalamic-Pituitary-Adrenal Axis in Health and Dysregulation in Psychiatric and Autoimmune Disorders
Tsigos, C., & Chrousos, G. P. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30078-1 · Cited by 203
Self-citation
Neural immune pathways and their connection to inflammatory diseases.
Eskandari, F., Webster, J. I., & Sternberg, E. M. (2003) · Arthritis Research · doi:10.1186/ar1002 · Cited by 201
Annexin‐A1: a pivotal regulator of the innate and adaptive immune systems
D’Acquisto, F., Perretti, M., & Flower, R. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.252 · Cited by 194
Etiology and Risk Factors for Rheumatoid Arthritis: A State-of-the-Art Review
Romão, V. C., & Fonseca, J. E. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.689698 · Cited by 228
Chronic stress, salivary cortisol, and α-amylase in children with asthma and healthy children
Wolf, J. M., Nicholls, E. F., & Chen, E. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.12.004 · Cited by 186
Monoclonal anti‐TNFα Antibody as a Probe of Pathogenesis and Therapy of Rheumatoid Disease
Maini, R. N., Elliott, M. J., BRENNAN, E. M., Williams, R. O., Chu, C., Paleolog, E. M., CHARLES, P. J., Taylor, P. C., & Feldmann, M. (1995) · Immunological Reviews · doi:10.1111/j.1600-065x.1995.tb00070.x · Cited by 181
Alcohol Stimulates ACTH Secretion in the Rat: Mechanisms of Action and Interactions with Other Stimuli
RIVIER, C. L. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01636.x · Cited by 180
Sex- and stress-steroids interactions and the immune system: evidence for a neuroendocrine-immunological sexual dimorphism
Gaillard, R. C., & Spinedi, E. (1998) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(98)00028-9 · Cited by 165
The neuroendocrine axis in patients with multiple sclerosis
Wei, T. C. (1997) · Brain · doi:10.1093/brain/120.6.1067 · Cited by 163
The remission of rheumatoid arthritis during pregnancy
Østensen, M., & Villiger, P. M. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0072-5 · Cited by 162
How stable are diurnal cortisol activity indices in healthy individuals? Evidence from three multi-wave studies
Ross, K. M., Murphy, M. L. M., Adam, E. K., Chen, E., & Miller, G. E. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.016 · Cited by 168
Towards a unified model of neuroendocrine–immune interaction
Petrovsky, N. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01029.x · Cited by 160
Adrenocortical and hemodynamic predictors of pain perception in men and women
Al’Absi, M., Petersen, K. L., & Wittmers, L. E. (2002) · Pain · doi:10.1016/s0304-3959(01)00447-x · Cited by 154
The role of stress in inflammatory disease, including periodontal disease: review of concepts and current findings
LeResche, L., & Dworkin, S. F. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.03009.x · Cited by 141
Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy
Geiss, A., Váradi, E., STEINBACH, K., Bauer, H. W., & Anton, F. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00810-0 · Cited by 138
Sex hormones, glucocorticoids and autoimmunity: facts and hypotheses.
da Silva, J. A. P. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.1.6 · Cited by 135
Brain-immune interactions and disease susceptibility
Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 134
Overnight variations in cortisol, interleukin 6, tumour necrosis factor α and other cytokines in people with rheumatoid arthritis
Perry, M. G., Kirwan, J., Jessop, D. S., & Hunt, L. P. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086561 · Cited by 130
Inflammation and cortisol response in coronary artery disease
Nijm, J., & Jonasson, L. (2009) · Annals of Medicine · doi:10.1080/07853890802508934 · Cited by 128
The Physiologic Effects of Pain on the Endocrine System
Tennant, F. S. (2013) · Pain and Therapy · doi:10.1007/s40122-013-0015-x · Cited by 138
Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients with psoriasis
Richards, H. L., Ray, D. W., Kirby, B., Mason, D., Plant, D., Main, C. J., Fortune, D. G., & Griffiths, C. E. M. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06817.x · Cited by 125
Beneficial effects of a 3-week course of intramuscular glucocorticoid injections in patients with very early inflammatory polyarthritis: results of the STIVEA trial
Verstappen, S. M. M., McCoy, M. J., Roberts, C., Dale, N., HASSELL, A. B., & Symmons, D. P. M. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.119149 · Cited by 125
Glucocorticoid sensitivity in humans-interindividual differences and acute stress effects
Rohleder, N., Wolf, J. M., & Kirschbaum, C. (2003) · Stress · doi:10.1080/1025389031000153658 · Cited by 118
Local and systemic glucocorticoid metabolism in inflammatory arthritis
Hardy, R., Rabbitt, E. H., Filer, A. D., Emery, P., Hewison, M., Stewart, P. M., Gittoes, N. J. L., Buckley, C. D., Raza, K., & Cooper, M. S. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.090662 · Cited by 118
Immunomodulation mechanism of antidepressants: interactions between serotonin/norepinephrine balance and Th1/Th2 balance
Martino, M., Rocchi, G., Escelsior, A., & Fornaro, M. (2012) · Current Neuropharmacology · doi:10.2174/157015912800604542 · Cited by 111
Impact of oral contraceptive use on glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress
Rohleder, N., Wolf, J. M., Piel, M., & Kirschbaum, C. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00019-7 · Cited by 115
Increased Corticosterone Pulse Frequency During Adjuvant‐Induced Arthritis and its Relationship to Alterations in Stress Responsiveness
Windle, R., Wood, S. A., Kershaw, Y. M., Lightman, S. L., Ingram, C. D., & Harbuz, M. S. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00715.x · Cited by 110
A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis
Mohr, D. C., & Pelletier, D. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.03.011 · Cited by 113
Age and sex steroid-related changes in glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress
Rohleder, N., Kudielka, B. M., Hellhammer, D. H., Wolf, J. M., & Kirschbaum, C. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00062-0 · Cited by 107
Stress system response and rheumatoid arthritis: a multilevel approach
Walker, J. G., Littlejohn, G. O., McMurray, N. E., & Cutolo, M. (1999) · Rheumatology · doi:10.1093/rheumatology/38.11.1050 · Cited by 108
Genetics of Rheumatoid Arthritis
Turesson, C., & Matteson, E. L. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.1.94 · Cited by 106
Organization and Integration of the Endocrine System: The Arousal and Sleep Perspective
Chrousos, G. P. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.04.004 · Cited by 108
Self-citation
Hypothalamo‐Pituitary‐Adrenal Axis and Chronic Immune Activation
Harbuz, M. S., CHOVER‐GONZALEZ, A. J., & Jessop, D. S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03141.x · Cited by 100
Urocortin Expression in Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis: Relation to Inflammatory Activity
Kohno, M., Kawahito, Y., Tsubouchi, Y., Hashiramoto, A., Yamada, R., Inoue, K., Kusaka, Y., Kubo, T., Elenkov, I. J., Chrousos, G. P., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7827 · Cited by 99
Self-citation
Gender differences in the development and function of the immune system
Shames, R. S. (2002) · Journal of Adolescent Health · doi:10.1016/s1054-139x(01)00382-2 · Cited by 98
Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Tomljenovic, L., & Shaw, C. (2012) · Lupus · doi:10.1177/0961203311430221 · Cited by 97
Hormonal and pregnancy relationships to rheumatoid arthritis: Convergent effects with immunologic and microvascular systems
Masi, A. T., Feigenbaum, S. L., & Chatterton, R. T. (1995) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(95)80014-x · Cited by 96
ANTERIOR PITUITARY FUNCTION IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS
Templ, E., Koeller, M., Riedl, M., Wagner, O., Graninger, W. B., & Luger, A. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.4.350 · Cited by 94
Endocrine stress responses in TH1-mediated chronic inflammatory skin disease (psoriasis vulgaris)—do they parallel stress-induced endocrine changes in TH2-mediated inflammatory dermatoses (atopic dermatitis)?
Buske-Kirschbaum, A., Ebrecht, M., Kern, S., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.10.006 · Cited by 91
Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis.
Swain, M. G., Patchev, V. K., Vergalla, J., Chrousos, G. P., & Jones, E. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116408 · Cited by 89
Self-citation
Perturbations of Arginine Vasopressin Secretion during Inflammatory Stress: Pathophysiologic Implications
Chikanza, I. C., Petrou, P., & Chrousos, G. P. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05448.x · Cited by 92
Self-citation
Humoral Mediation of Changing Body Composition During Aging and Chronic Inflammation
Roubenoff, R., & Rall, L. C. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1993.tb03045.x · Cited by 89
The adrenal steroid status in relation to inflammatory cytokines (interleukin‐6 and tumour necrosis factor) in polymyalgia rheumatica
Straub, R. H., Glück, T., Cutolo, M., Georgi, J., Helmke, K., Schölmerich, J., Vaith, P., & Lang, B. (2000) · Rheumatology · doi:10.1093/rheumatology/39.6.624 · Cited by 84
Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance
Finn, D. P. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.05.011 · Cited by 91
Determinants of the NF-κB response to acute psychosocial stress in humans
Wolf, J. M., Rohleder, N., Bierhaus, A., Nawroth, P. P., & Kirschbaum, C. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.09.009 · Cited by 89
Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level
Kouri, V., Olkkonen, J., Kaivosoja, E., Ainola, M., Juhila, J., Hovatta, I., Konttinen, Y. T., & Mandelin, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054049 · Cited by 86
The hypothalamic–pituitary–adrenal axis in the pathogenesis of rheumatic diseases
Crofford, L. J. (2002) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(01)00004-4 · Cited by 86
The corticotrophin-releasing factor-binding protein: an act of several parts
Kemp, C. F., Woods, R. J., & Lowry, P. J. (1998) · Peptides · doi:10.1016/s0196-9781(98)00057-6 · Cited by 85
Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women
Roche, D. J. O., King, A. C., Cohoon, A. J., & Lovallo, W. R. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.05.007 · Cited by 81
Activation of the HPA axis by immune insults: Roles and interactions of cytokines, eicosanoids, and glucocorticoids
Buckingham, J. C., Loxley, H. D., Christian, H., & Philip, J. G. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02127-2 · Cited by 81
HORMONAL ALTERATIONS IN RHEUMATOID ARTHRITIS, INCLUDING THE EFFECTS OF PREGNANCY
Kanik, K. S., & Wilder, R. L. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70170-8 · Cited by 80
Increased activity of hypothalamic corticotropin-releasing hormone neurons in multiple sclerosis
Erkut, Z. A., Hofman, M. A., Ravid, R., & Swaab, D. F. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00098-m · Cited by 79
EXERCISE, EDUCATION, AND BEHAVIORAL MODIFICATION AS ALTERNATIVE THERAPY FOR PAIN AND STRESS IN RHEUMATIC DISEASE
Yocum, D. E., Castro, W. L., & Cornett, M. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70128-9 · Cited by 77
Adrenocorticotropin, Glucocorticoid, and Androgen Secretion in Patients with New Onset Synovitis/Rheumatoid Arthritis: Relations with Indices of Inflammation1
Kanik, K. S., Chrousos, G. P., Schumacher, H. R., Crane, M., Yarboro, C. H., & Wilder, R. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6534 · Cited by 79
Self-citation
Involvement and Role of the Hypothalamo-pituitary-adrenal (HPA) Stress Axis in Animal Models of Chronic Pain and Inflammation
Bomholt, S. F., Harbuz, M. S., Blackburn-Munro, G., & Blackburn-Munro, R. E. (2004) · Stress · doi:10.1080/10253890310001650268 · Cited by 78
Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
van Oosten, M. J. M., Dolhain, R. J. E. M., Koper, J. W., van Rossum, E. F. C., Emonts, M., Han, K. H., Wouters, J. M. G. W., Hazes, J. M., Lamberts, S. W. J., & Feelders, R. A. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3118 · Cited by 76
Defective corticotropin-releasing hormone mediated neuroendocrine and behavioral responses in cholestatic rats: Implications for cholestatic liver disease-related sickness behaviors
Swain, M. G., & Maric, M. (1995) · Hepatology · doi:10.1002/hep.1840220532 · Cited by 75
Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis
Tang, M. W., García, S., Gerlag, D. M., Tak, P. P., & Reedquist, K. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00720 · Cited by 74
Immune‐Neuroendocrine Interactions and Autoimmune Diseases
Jara, L. J., Navarro, C., Medina, G., Lastra, O. L. V., & Blanco, F. (2006) · Journal of Immunology Research · doi:10.1080/17402520600877059 · Cited by 71
Detection of Intracellular Lipocortin 1 in Human Leukocyte Subsets
Morand, E. F., Hutchinson, P. E., Hargreaves, A., Goulding, N. J., Boyce, N., & Holdsworth, S. R. (1995) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1995.1115 · Cited by 70
Glucocorticoid resistance syndrome: a diagnostic and therapeutic approach
van Rossum, E. F. C., & Lamberts, S. W. J. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.09.005 · Cited by 69
RECIPROCAL INTERACTIONS BETWEEN THE NEUROENDOCRINE AND IMMUNE SYSTEMS DURING INFLAMMATION
Chikanza, I. C., & Grossman, A. B. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70165-4 · Cited by 70
Self-citation
Negative feedback neuroendocrine control of the inflammatory response in rats
Green, P. G., Miao, F., Jänig, W., & Levine, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04678.1995 · Cited by 70
Hormonal Regulation of Tumor Necrosis Factor‐α, Interleukin‐12 and Interleukin‐10 Production by Activated Macrophages: A Disease‐modifying Mechanism in Rheumatoid Arthritis and Systemic Lupus Erythematosus?
Wilder, R. L., & Elenkov, I. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07619.x · Cited by 67
The three-way interactions between the hypothalamic-pituitary-adrenal and gonadal axes and the immune system
Torpy, D. J., & Chrousos, G. P. (1996) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(96)80014-8 · Cited by 68
Self-citation
Central/peripheral nervous system and immune responses
Lawrence, D. A. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00144-4 · Cited by 67
Neuroendocrine-immune system interactions
Gaillard, R. C. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)p3206-m · Cited by 67

Authors: Chikanza, I. C., Petrou, P., Kingsley, G., Chrousos, G., & Panayi, G. S.
Affiliations: Guy's Hospital (GB)
Corresponding author: Panayi, Gabriel S.
ORCID: Chikanza, Ian C.
Petrou, Petros
Chrousos, George
Venue: Arthritis & Rheumatism
Publisher: Wiley
Published: 1992-11
Volume: 35
Issue: 11
Pages: 1281-1288
ISSN: 0004-3591 (ISSN-L)
1529-0131
DOI: 10.1002/art.1780351107
OpenAlex: W1718876362
Cited by: 337
References: 35
Citations by year: 2026: 5 · 2025: 1 · 2024: 5 · 2023: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 9
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7885 d)
Locations: Arthritis & Rheumatism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: rheumatoid arthritis, hypothalamic-pituitary-adrenal axis, hypothalamic dysfunction, cortisol secretion, diurnal cortisol rhythm, corticotropin-releasing hormone stimulation test, IL-1β, interleukin-6, chronic osteomyelitis, inflammatory stimuli
MeSH terms: Adult, Aged, Arthritis, Rheumatoid, Circadian Rhythm, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Hypothalamus, Immune System, Male, Middle Aged, Postoperative Period, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks