The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus
Abstract
OBJECTIVE: To test the reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) in the assessment of patients with SLE. METHODS: Ten patients with SLE, representing a spectrum of damage and activity, were included. Each patient was examined by 6 of 10 physicians from 5 countries, representing 10 lupus clinics. The SLICC/ACR Damage Index was used to assess accumulated damage, and the SLEDAI was used to assess disease activity. The order of the patients and physicians was randomized according to a Youden square design. RESULTS: The SLICC/ACR Damage Index detected differences among patients (P < 0.001). There was no detectable observer difference (P = 0.933), and there was no order effect (P = 0.261). Similar results were obtained with the SLEDAI. There was concordance in the SLICC/ACR Damage Index among observers, despite a wide spectrum of disease activity detected by the SLEDAI. CONCLUSION: Physicians from different centers are able to assess patients with SLE in a reproducible way, using the SLEDAI to assess disease activity and the SLICC/ACR Damage Index to assess accumulated damage.
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“We found no association between AmtRNA-IgG and two clinical indices; one measuring SLE disease activity (SLEDAI-2K ≥ 4) and the other indicating damages (SDI > 0), both by biand multivariate analyses.”
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- Authors
- Gladman, D. D., Urowitz, M. B., Goldsmith, C. H., Fortin, P., Ginzler, E., Gordon, C., Hanly, J. G., Isenberg, D. A., Kalunian, K., Nived, O., Petri, M., Sanchez‐Guerrero, J., Snaith, M., & Sturfelt, G.
- Affiliations
- McMaster University (CA)
- Montreal General Hospital (CA)
- University of Birmingham (GB)
- Dalhousie University (CA)
- University College London (GB)
- University of California, Los Angeles (US)
- Skåne University Hospital (SE)
- Johns Hopkins University (US)
- University of Sheffield (GB)
- ORCID
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1997-05
- Volume
- 40
- Issue
- 5
- Pages
- 809-813
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2022070992
- Cited by
- 759
- References
- 12
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 32 · 2023: 17 · 2022: 28 · 2021: 46 · 2020: 28 · 2019: 24 · 2018: 33 · 2017: 39 · 2016: 46 · 2015: 37 · 2014: 35 · 2013: 46 · 2012: 28
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Keywords
- systemic lupus erythematosus, SLICC/ACR damage index, SLEDAI, disease activity assessment, damage assessment, inter-rater reliability, interobserver agreement, order effects
- MeSH terms
- Adult, Aged, Analysis of Variance, Female, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Severity of Illness Index, Reproducibility of Results
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