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Cited by 352

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor α in collagen‐induced arthritis

Open access
Djouad, Farida, Fritz, Vanessa, Apparailly, Florence, Louis‐Plence, Pascale, Bony, Claire, Sany, Jacques, Jorgensen, Christian, Noël, Danièle·2005·Arthritis & Rheumatism
DOI 10.1002/art.21012
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Abstract

Objective: Adult mesenchymal stem cells (MSCs) represent promising tools for therapeutic applications such as tissue engineering and cellular therapy. Recent data suggest that, due to their immunosuppressive nature, MSCs may be of interest to enhance allogeneic hematopoietic engraftment and prevent graft‐versus‐host disease. Using a murine model of rheumatoid arthritis (RA), this study investigated whether the immunosuppressive properties of MSCs could be of therapeutic value to inhibit reactive T cells in autoimmune diseases such as RA. Methods: In mice with collagen‐induced arthritis (CIA), we injected various doses of C3 MSCs at the time of immunization or booster injection, and subsequently evaluated the clinical and immunologic parameters. The immunosuppressive properties of MSCs were determined in vitro in mixed lymphocyte reactions with or without the addition of tumor necrosis factor α (TNFα). Results: In the CIA model of arthritis, MSCs did not confer any benefit. Both the clinical and the immunologic findings suggested that MSCs were associated with accentuation of the Th1 response. Using luciferase‐expressing MSCs, we were unable to detect labeled cells in the articular environment of the knee, suggesting that worsening of the symptoms was unlikely due to the homing of MSCs in the joints. Experiments in vitro showed that the addition of TNFα was sufficient to reverse the immunosuppressive effect of MSCs on T cell proliferation, and this observation was associated with an increase in interleukin‐6 secretion. Conclusion: Our data suggest that environmental parameters, in particular those related to inflammation, may influence the immunosuppressive properties of MSCs.

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Metadata

Authors
Djouad, F., Fritz, V., Apparailly, F., Louis‐Plence, P., Bony, C., Sany, J., Jorgensen, C., & Noël, D.
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
2005-05
Volume
52
Issue
5
Pages
1595-1603
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.21012
OpenAlex
W2006601515
Cited by
352
References
2
FWCI
9.46
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4 d)

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CoChat. (2026). Citation check: Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor α in collagen‐induced arthritis. https://app.cochat.ai/papers/10.1002/art.21012
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Djouad, F., Fritz, V., Apparailly, F., Louis‐Plence, P., Bony, C., Sany, J., Jorgensen, C., & Noël, D. (2005). Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor α in collagen‐induced arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.21012

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.