The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Reproductive and menopausal factors and risk of systemic lupus erythematosus in women
Abstract
Objective: Systemic lupus erythematosus (SLE) occurs predominantly in women, and hormones may play a role in its etiology. This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE. Methods: A cohort of 238,308 women was prospectively examined. Subjects were older women (ages 30–55 years at start) and younger women (ages 25–42 years at start) from the Nurses' Health Study (NHS) and NHSII cohorts. Incident SLE diagnosed between 1976 and 2003 was confirmed by medical record review. The relative risk (RR) of SLE was estimated separately in each cohort using Cox proportional hazards models, and then pooled using meta‐analysis random effects models. Results: Two hundred sixty‐two incident cases of SLE were confirmed among the women. In multivariable models adjusted for reproductive and other risk factors, age ≤10 years at menarche (pooled RR 2.1, 95% confidence interval [95% CI] 1.4–3.2), oral contraceptive use (pooled RR 1.5, 95% CI 1.1–2.1), and use of postmenopausal hormones (RR 1.9, 95% CI 1.2–3.1) significantly increased the risk of SLE. An elevation of SLE risk was observed among postmenopausal women primarily after surgical menopause (RR 2.3, 95% CI 1.2–4.5), and also among women with earlier age at natural menopause (P for trend < 0.05). Menstrual irregularity was associated with an increased risk of SLE among women in the younger (NHSII) cohort. Age at first birth, parity, and total duration of breastfeeding were not associated with SLE. Conclusion: Early age at menarche, oral contraceptive use, early age at menopause, surgical menopause, and postmenopausal use of hormones were each associated with an increased risk of SLE. These associations may point to the mechanisms underlying the pathogenesis of SLE.
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Meta-analysis in clinical trials
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The 1982 revised criteria for the classification of systemic lupus erythematosus
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Combined Oral Contraceptives in Women with Systemic Lupus Erythematosus
Petri, M., Kim, M. Y., Kalunian, K. C., Grossman, J., Hahn, B. H., Sammaritano, L. R., Lockshin, M., Merrill, J. T., Belmont, H. M., Askanase, A. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051135 · Cited by 1,166
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Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992
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Estrogen alters thresholds for B cell apoptosis and activation
Grimaldi, C. M., Cleary, J., Dagtas, A. S., Moussai, D., & Diamond, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14873 · Cited by 461
REPRODUCIBILITY AND VALIDITY OF SELF-REPORTED MENOPAUSAL STATUS IN A PROSPECTIVE COHORT STUDY
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Self-citationWalther, M., Harms, H., Krenn, V., Radke, S., Faehndrich, T.-P., & Gohlke, F. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200102)44:2<331::aid-anr50>3.0.co;2-0 · Cited by 447
Estrogen alters thresholds for B cell apoptosis and activation
Grimaldi, C. M., Cleary, J., Dagtas, A. S., Moussai, D., & Diamond, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214873 · Cited by 425
Cited by
Gender differences in autoimmune disease
Ngo, S. T., Steyn, F. J., & McCombe, P. A. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.004 · Cited by 1,074
Lisnevskaia, L., Murphy, G., & Isenberg, D. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60128-8 · Cited by 752
Endometriosis: a high-risk population for major chronic diseases?
Kvaskoff, M., Mu, F., Terry, K. L., Harris, H. R., Poole, E. M., Farland, L., & Missmer, S. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv013 · Cited by 439
Sex steroids as inflammatory regulators
Gilliver, S. C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.015 · Cited by 198
Environmental Basis of Autoimmunity
Floreani, A., Leung, P. S. C., & Gershwin, M. E. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8493-8 · Cited by 122
Metadata
- Authors
- Costenbader, K. H., Feskanich, D., Stampfer, M. J., & Karlson, E. W.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2007-03-28
- Volume
- 56
- Issue
- 4
- Pages
- 1251-1262
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1974187993
- Cited by
- 349
- References
- 53
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Costenbader, K. H., Feskanich, D., Stampfer, M. J., & Karlson, E. W. (2007). Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis & Rheumatism. https://doi.org/10.1002/art.22510
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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