Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., Thompson, E. W.·2009·Arthritis & Rheumatism
Cited by (648)
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- Proteases and Cartilage Degradation in OsteoarthritisJudith Farley, C. Valeria, John S. · 2012 · InTech eBooks
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- ILK inhibition reduces osteophyte formation through suppression of osteogenesis in BMSCs via Akt/GSK-3β/β-catenin pathwayZhixiang Huang, Huang Li-xin, Jiali Ding, Yukai Huang, Xuechan Huang, T W LI · 2024 · Molecular Biology Reports
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- Protective effects of calcitonin on IL-1 stimulated chondrocytes by regulating MMPs/TIMP-1 ratio via suppression of p50-NF-κB pathwayXiaodong Bai, Ai Guo, Yadong Li · 2018 · Bioscience Biotechnology and Biochemistry
- Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13Aya Miyauchi, Masahito Noguchi, Xiao‐Feng Lei, Masashi Sakaki, Momoko Kobayashi, Shogo Haraguchi, Akira Miyazaki, Joo‐ri Kim‐Kaneyama · 2023 · Scientific Reports
- Synergy between cyclooxygenase-2 inhibitors and hyaluronic acid in the treatment of osteoarthritis: Illumination of signaling cascade, nanotechnology-driven delivery strategies and future prospectsSamiksha Thote, Priyanka Gorella, Shristi Arya, Atul Mourya, Pawan Devangan, Vaskuri G. S. Sainaga Jyothi, Chantibabu Katta, Shashi Bala Singh, Neelesh Kumar Mehra, Jitender Madan · 2024 · Journal of Drug Delivery Science and Technology
- Osteoarthritis – Genetic Studies of Monogenic and Complex FormsAna Maria Valdes · 2012 · Elsevier eBooks
- Dehydroepiandrosterone and Experimental OsteoarthritisKai Huang, Lidong Wu, Jiapeng Bao · 2018 · Vitamins and hormones
- The Analysis of the Relationship between RELA Gene Expression and MMP-13 Gene Expression in Synoviocyte Cells after Mesenchymal Stem Cell Wharton JellyVivi Sofia, Ellyza Nasrul, Menkher Manjas, Gusti Revilla · 2019 · Open Access Macedonian Journal of Medical Sciences
- Tyr-Tyr-Glu Tripeptide for Regeneration of Articular Cartilage through Chondrogenic Differentiation of Mesenchymal Stem CellsYe Lin Kim, Soyoun Um, Madhumita Patel, Yeon-Ju Jung, Sun‐Shin Cha, Jihee Kim, Soo Young Lee, Byeongmoon Jeong · 2025 · Biomaterials Research
- Investigation of GPM6B as a novel therapeutic target in OsteoarthritisChongyang Feng, Lin Liu, Jinxue Zhang, Linxiao Wang, Ke Lv, Hongbo Li, Yong Ding · 2024 · Arthritis Research & Therapy
- Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in AtherosclerosisAriel Buchler, Uzair S. Ismailani, Nicole MacMullin, Faduma Abdirahman, Myriam Adi, Christina Bi, Catherine Jany, Jeffrey W. Keillor, Benjamin H. Rotstein · 2023 · Journal of Medicinal Chemistry
- Kartogenin Induces Chondrogenesis in Cartilage Progenitor Cells and Attenuates Cell Hypertrophy in Marrow-Derived Stromal CellsDaniel S. Yang, Jay Trivedi, Daniel J. Betensky, Salomi Desai, Brett D. Owens, Chathuraka T. Jayasuriya · 2024 · Current Stem Cell Research & Therapy
- Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint FormationYingcui Li, Alexander Tress, Peter F. Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny Sun-Kin Chan et al. · 2025 · Biomedicines
- Potential Targets for Pharmacologic Therapies for Prevention of PTACecilia Pascual‐Garrido, Susan Chubinskaya · 2015 · Springer eBooks
- Anatomy and Function of Articular CartilageAlberto W. Gobbi, Eleonora Irlandini, Alex P. Moorhead · 2021 · Springer eBooks
- CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic OsteoarthritisHelen H. Willcockson, Huseyin Ozkan, José Valdés‐Fernández, Liubov S Arbeeva, Esra Mucahit, Layla Musawwir, Lola Bleu Hooper, Froilán Granero‐Moltó, Felipe Prósper, Lara Longobardi · 2023 · Biomolecules
- Small animal models to understand pathogenesis of osteoarthritis and use of stem cell in cartilage regenerationVirginia Piombo · 2017 · Cell Biochemistry and Function
- Cartilage Injury and OsteoarthritisHeba M. Ismail, Tonia L. Vincent · 2017 · Springer eBooks
- Drilling Down to the Bone: Evaluating Bone Marrow Lesions in OsteoarthritisNidhi Sofat · 2018 · EMJ Rheumatology
- Matrix Metalloproteinases in Bone Health and DiseaseStav Simsa-Maziel, Dalit Sela‐Donenfeld, Efrat Monsonego Ornan · 2013 · Springer eBooks
- Metalloproteinases in Cartilage Matrix Breakdown: The Roles in Rheumatoid Arthritis and OsteoarthritisHideaki Nagase, Gillian Murphy · 2013 · Springer eBooks
- Surgical Induction of Posttraumatic Osteoarthritis in the MouseRobert D. Maynard, David A. Villani, William G. Schroeder, Douglas J. Adams, Michael J. Zuscik · 2020 · Methods in molecular biology
- Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to drive osteoarthritisAlexander J. Knights, Easton C. Farrell, Olivia M. Ellis, Lindsey Lammlin, Lucas M. Junginger, Phillip Rzeczycki, Rachel F. Bergman, Rida Pervez, Monique Cruz, Alexa A. Samani et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Editorial Commentary: High Tibial Osteotomy and Distal Femoral Osteotomy Address Biologics and BiomechanicsJames D. Wylie · 2024 · Arthroscopy The Journal of Arthroscopic and Related Surgery
- Sustained release of exogeneous fetuin-A from Hyaluronic acid microplates decreases joint degeneration, synovial hyperplasia and muscle damage in a murine post-traumatic osteoarthritis modelHelen H. Willcockson, Antonietta Greco, Agnese Fragassi, Roberto Palomba, Kihyun Kwon, Hüseyin Özkan, Samuel T. Bartlett, Richard F. Loeser, Paolo Decuzzi, Lara Longobardi · 2025 · Arthritis Research & Therapy
- Cxcl9-deficiency attenuates the progression of post-traumatic osteoarthritis in miceAntonia Donat, Weixin Xie, Shan Jiang, Laura Brylka, Thorsten Schinke, Tim Rolvien, Karl‐Heinz Frosch, Anke Baranowsky, Johannes Keller · 2025 · Inflammation Research
- The Causal Relationship Between Zinc and Osteoarthritis: A Two-Sample Mendelian Randomization StudyTianqi Gao, TianYang Chen, Chenglong Ai, Yan Gu, YunPeng Wang, Xiaoling Zhou, ChangWei Zhao · 2025 · Biological Trace Element Research
- Glatiramer acetate (GA), the immunomodulatory drug, inhibits inflammatory mediators and collagen degradation in osteoarthritis (OA) cartilageMukundan G Attur, Jennifer S. Millman, Mandar N. Dave, H. Al-Mussawir, J. Patel, Glyn D. Palmer, Steven B. Abramson · 2011 · Osteoarthritis and Cartilage
- Effect of Estradiol on Chondrocytes in the Active Stage of Collagenase- Induced OsteoarthritisNina Ivanovska, Petya Ganova, Lyudmila Filipova Belenska-Todorova · 2022 · Current Bioactive Compounds
- The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing?D. Wilkinson · 2022 · Osteoarthritis and Cartilage
- Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis developmentQuan Hong, Zhong-Xun Liu, Haifeng Liang, Deguang Wu, Yan Chen, Bo Yu · 2024 · Journal of Orthopaedic Surgery and Research
- Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophyJiajin Fang, Shuai Wang · 2025 · Frontiers in Surgery
- Innate immune pathway activated mesenchymal stromal cells improve function and histologic outcomes in a rodent osteoarthritis modelCody Plaisance, Lyndah Chow, Renata A. Impastato, Zoë J. Williams, Isabella Sabino, Katie J. Sikes, Kelly S. Santangelo, STEVEN W. DOW, Lynn Marie Pezzanite · 2025 · Frontiers in Bioengineering and Biotechnology
- Evaluation of ALK5 and MMP13 Expression in the Cartilage Tissue of Rats with Osteoarthritis Rats and Effects of Exercise Training, Ozone and Mesenchymal Stem Cell Therapies on Expression of these GenesSamira Oladazimi, Parvin Farzanegi, Mohammad Ali Azarbayjani · 2020 · Medical Laboratory Journal
- Application of Formononetin for the Treatment of Knee Osteoarthritis Induced by Medial Meniscectomy in a Rodent ModelRonald Bispo Barreto da Silva, Bruna Henriques de Santana, Beatriz M. Martins, Erick Sobral Porto, Patrícia B. Severino, Juliana Cordeiro Cardoso, Eliana B. Souto, Ricardo Luiz Cavalcanti de Albuquerque Júnior · 2022 · Applied Sciences
- The recent paper “Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity”S. Glasson, Christopher B. Little · 2011 · Osteoarthritis and Cartilage
- Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuriesZirui Zhang, Pengfei Yao, Shuai Fan · 2024 · Regenerative Medicine
- POSTN potentiates chondrocyte hypertrophy by promoting RUNX2 in osteoarthritisRuiyang Jiang, Maochun Wang, Guihua Tan, Siyu Xu, Zizheng Liu, Xiyu Liu, Weitong Li, Hu Guo, Jingjing Fan, Wei Sun et al. · 2025 · Genes & Diseases
- M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapyWeibei Sheng, Lian Li, Zimeng Zhou, Jin Zhao, Shaohua Ma, Yaohang Yue, Jian Weng, Ao Xiong, Deli Wang, Jianjing Lin et al. · 2025 · Materials Today Bio
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital ModellingMikołaj Stańczak, Bartłomiej Kacprzak, Magdalena Hagner-Derengowska · 2026 · International Journal of Molecular Sciences
- The role and mechanism of biological collagen membranes in repairing cartilage injury through the p38MAPK signaling pathwayLibo Yuan, Tao Jin, Ling Yao, De-Hong Yin, Yongqing Xu · 2023 · Journal of Orthopaedic Surgery and Research
- Long-term effects of non-weight bearing and immobilization after anterior cruciate ligament reconstruction on joint contracture formation in ratsAkinori Kaneguchi, Nanami Masuhara, Ryo Okahara, Yoshika Doi, Kaoru Yamaoka, Takuya Umehara, Junya Ozawa · 2024 · Connective Tissue Research
- Effects of sex differences on osteoarthritic changes after anterior cruciate ligament reconstruction in ratsAkinori Kaneguchi, Marina Kanehara, Kaoru Yamaoka, Takuya Umehara, Junya Ozawa · 2024 · Acta Histochemica
- Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in miceKai-Zhen Xiao, Gui Liao, Guang-Yu Huang, Yunlong Huang, Ronghe Gu · 2024 · World Journal of Stem Cells
- Joint damage is more severe following a single bout than multiple bouts of high magnitude loading in miceSophia N. Ziemian, Adrien Y. Antoinette, Ana M. Witkowski, Miguel Otero, Steven R. Goldring, Mary B. Goldring, Marjolein C. H. van der Meulen · 2025 · Osteoarthritis and Cartilage
- Integrin-linked kinase-mediated promotion of osteogenic differentiation in bone marrow mesenchymal stem cells: A driver of heterotopic ossification in ankylosing spondylitisZhixiang Huang, Yinyu Li, Guozhen Hu, Jiali Ding, Meng Liu, Yukai Huang, Xuechan Huang, T W LI · 2025 · Bone
- Genetic Mouse Models for Osteoarthritis ResearchJie Shen, Meina Wang, Hongting Jin, Erik R. Sampson, Di Che · 2012 · InTech eBooks
- Potential Mechanisms of PTOA: InflammationMary B. Goldring · 2015 · Springer eBooks
- On the Horizon From the ORSChristopher B. Little, Young‐Jo Kim · 2010 · Journal of the American Academy of Orthopaedic Surgeons
- Intra-articular injection of clioquinol ameliorates osteoarthritis in a rabbit modelXiaoqing Wu, Peng Xu, Xuanren Shi, Jian Shang, Xiaoyong Chen, Anyun Guo, Fuming Wang, Zhanhai Yin · 2022 · Frontiers in Medicine
- T cells Mediate Progression of Load-Induced OsteoarthritisTibra A. Wheeler, Adrien Y. Antoinette, Matthew Kim, Marjolein C. H. van der Meulen, Ankur K. Singh · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Appraising the evolving landscape of protease inhibition in osteoarthritisMuhammad Farooq Rai · 2024 · Nature Reviews Rheumatology
- Nanotechnology-Based Therapeutic Approaches for the Management of OsteoarthritisMrinmoy Ghosh, Md. Meraj Ansari, Young‐Ok Son · 2025 · Smart nanomaterials technology
- Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritisCristal S. Yee, Marianne Demirdji, Karsyn N. Bailey, Alena D. Larios, Christoforos Meliadis, Clarissa Aguirre Luna, Harrison B. Taylor, Peggi M. Angel, Sunil D. Kapila, Tamara N. Alliston · 2025 · Osteoarthritis and Cartilage
- Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signalingDalin Chen, Chong Wang, Changsheng Yang, Qinwei Cheng, Liangyu Chen, Panpan Yang, Zilin Zou, Zining Wang, Honghao Li, Yun Xiao et al. · 2026 · Nature Communications
- A Novel Concept of Tissue Micro-Instability as the Underlying Mechanism of Osteophytosis in Human Knee OsteoarthritisAlexey V. Volkov, Лялина Вера Валерьевна, Gulnara Eshmotova, Natalia Serejnikova, Sofia Petrova, George Airapetov, Evgeniya Parshina, Anton Zalygin, Е. D. Belitskaya, В. А. Олейников et al. · 2026 · Biomedicines
- Exosomes in Osteoarthritis: Emerging Roles in Pathogenesis, Diagnosis, and Therapeutic PotentialAbolfazl Bagherifard, Sina Talebi, Ahmad Hemmatyar, Khatere Mokhtari, Hooman Yahyazedeh, Hamid Tanzadehpanah · 2026 · Current Pharmaceutical Design
- The calcitonin receptor controls osteophyte formation, but not cartilage degeneration and subchondral bone loss in experimental osteoarthritisShan Jiang, Weixin Xie, Tobias Malte Ballhause, Jan Sevecke, Ruben Augustin, Tim Rolvien, Tazio Maleitzke, Anke Baranowsky, Johannes Keller · 2026 · Bone and Joint Research
- Small heterodimer partner protects against osteoarthritis by inhibiting IKKβ/NF-κB-mediated matrix-degrading enzymes in chondrocytesE. S. Kang, Jung‐Ran Noh, J S Kim, Ji Ah Park, Jeong-Pin Ahn, M Kim, Jung Hyeon Choi, Young‐Keun Choi, In-Bok Lee, Dong‐Hee Choi et al. · 2026 · Nature Communications
- Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritisHiroki Mukoyama, Yusuke Takeuchi, Daiya Ohara, Yoonha Lee, Hitomi Watanabe, Hiroki Kato, Gen Kondoh, Akio Morinobu, Keiji Hirota · 2026 · Science Advances
- KPT-330 alleviates osteoarthritis by inhibiting subchondral bone osteoclastogenesis via the NF-κB and MAPK signaling pathways陈武桂, Yijie Liang, Chengzhao Liu, Guangfeng Ling, ShiQing Lei, Jiaqing Huang, Lili Wang, C Koo Seen Lin · 2026 · iScience
- In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis EmergenceAikta Sharma, Lucinda Evans, Lucie E. Bourne, Jishizhan Chen, Alissa Louise Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter David Lee et al. · 2026 · Advanced Science
- Hypertension fuels osteoarthritis through neuroendocrine signalingSu-Jin Kim, Hyoeun Kim, Ki‐Ho Chung, Gyuseok Lee, Ka Hyon Park, Young-Gwon Kim, Mangeun Kim, Weon-Young Choi, Soo-Chang Joo, Hae Jin Kee et al. · 2026 · Science
- Post-Traumatic Osteoarthritis: Biologic Approaches to TreatmentSukhwinderjit Lidder, Susan Chubinskay · 2012 · InTech eBooks
- Pathogenic protease expression in murine OA is critically dependent upon mechanical joint loadingAnnika Burleigh, Anastasios Chanalaris, Jeremy Saklatvala, Tonia L. Vincent · 2012 · Arthritis Research & Therapy
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- Genetic Study of Zinc Transporters and Zinc SignalingToshiyuki Fukada · 2016 · Elsevier eBooks
- Antioxidant microspheres as drug delivery vehicles for the prevention of post-traumatic osteoarthritisTaylor E. Kavanaugh · 2017
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- CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritisLindsey Lammlin, Stephen J. Redding, Alexander J. Knights, Aanya Mohan, Michael D. Newton, Rachel F. Bergman, Isabelle J. Smith, Scarlet C. Howser, Sofia Gonzalez-Nolde, Phillip Rzeczycki et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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- Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis Nitya N. PathakMadhu C. LingarajuVenkanna Balaganur •Surendra Kumar Tandan · 2015
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- This information is current as Metalloproteinase-3 and -13 Zymogens Cartilage by Activating Matrix Articular Tryptases Induce Aggrecanolysis in Restricted, Tetramer-Forming - Mast CellRoberto Adachi, Richard L Stevens, H Lizotte Patrick, Natalia J. Magarinos, Katherine J. Bryant, Amanda Mercedes Jamieson · 2013
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- Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritisJonathan A. Green · 2015 · UEA Digital Repository (University of East Anglia)
- Tissue destruction and repairTim E. Cawston, David Alan Young, Drew D. Rowan · 2015 · Elsevier eBooks
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- Discoidin Domain Receptor 2 in Development of OsteoarthritisLin Xu, Peter L. Lee, Yefu Li · 2016 · Springer eBooks
- WNT16 in Chondrocyte Biology and Lineage DeterminationBethan Lynne Thomas · 2015
- Egg-yolk peritonitis in a cockatiel.Rosskopf Wj, Richard W. Woerpel, E B Howard, Annette Gendron · 1982 · PubMed
- Protective effect of glucosamine cyclohexyl ester on osteoarthritis in rat via targeting expressions of matrix metalloproteinase and tissue inhibitor of metalloproteinases-1Wei Shui, Gang Luo, Bo Qiao, Weidong Ni, Shuquan Guo · 2017 · Tropical Journal of Pharmaceutical Research
- Comparison of cartilage between CD and NCD breeds by researching the Wnt/β-catenin pathwayDanen, I. · 2018 · Utrecht University Repository (Utrecht University)
- Osteoarthritis: Genetic Studies of Monogenic and Complex FormsAna Maria Valdes · 2017 · Elsevier eBooks
- Die DDR-1-knockout-Maus – ein neues Tiermodell für Osteoarthritis im KiefergelenkLeonard Hoene · 2019
- TGF–β Signaling, Joint Development and HomeostasisTieshi Li, Jay Jiang, Xin Jin, Anna Spagnoli · 2020 · Elsevier eBooks
- Porphyrin Molecular Beacons – a New Approach to OsteoarthritisConnor D. Walsh · 2019 · TSpace (University of Toronto)
- Gentiana macrophylla exhibits a potential therapeutic effect on osteoarthritis (OA) via modulating disease-related proteinsHaitao Xu, Ningyang Gao, Yuxin Zheng · 2021 · Archives of Medical Science