Werb, Zena

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature

Immune cells in cancerInflammatory mediators and NSAID effects

Cited by 15,111

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer

Protease and Inhibitor MechanismsTGF-β signaling in diseases

Cited by 6,108

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell

Protease and Inhibitor MechanismsTGF-β signaling in diseases

Cited by 5,151

Remodelling the extracellular matrix in development and disease

Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology

Protease and Inhibitor MechanismsCellular Mechanics and Interactions

Cited by 4,367

How Matrix Metalloproteinases Regulate Cell Behavior

Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology

Protease and Inhibitor MechanismsTGF-β signaling in diseases

Cited by 3,959

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 3,863

The extracellular matrix: A dynamic niche in cancer progression

Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 3,024

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology

Angiogenesis and VEGF in CancerProtease and Inhibitor Mechanisms

Cited by 2,797

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications

Cellular Mechanics and InteractionsProtease and Inhibitor Mechanisms

Cited by 2,296

Extracellular Matrix Degradation and Remodeling in Development and Disease

Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011) · Cold Spring Harbor Perspectives in Biology

Protease and Inhibitor MechanismsCellular Mechanics and Interactions

Cited by 2,265

Lifeact: a versatile marker to visualize F-actin

Riedl, J., Crevenna, A. H., Kessenbrock, K., Yu, J. H., Neukirchen, D., Bista, M., Bradke, F., Jenne, D., Holak, T. A., Werb, Z., et al. (2008) · Nature Methods

Cellular Mechanics and InteractionsAdvanced Fluorescence Microscopy Techniques

Cited by 2,189

Roles of the immune system in cancer: From tumor initiation to metastatic progression

Gonzalez, H., Hagerling, C., & Werb, Z. (2018) · Genes & Development

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 2,111

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

Plaks, V., Kong, N., & Werb, Z. (2015) · Cell Stem Cell

Cancer Cells and MetastasisMesenchymal stem cell research

Cited by 1,557

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell

Protease and Inhibitor MechanismsImmune cells in cancer

Cited by 1,306

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Radisky, D. C., Levy, D. D., Littlepage, L. E., Liu, H., Nelson, C. M., Fata, J. E., Leake, D., Godden, E. L., Albertson, D. G., Angela Nieto, M., et al. (2005) · Nature

Protease and Inhibitor MechanismsCancer Cells and Metastasis

Cited by 1,284

Regulation of matrix biology by matrix metalloproteinases

Mott, J. D., & Werb, Z. (2004) · Current Opinion in Cell Biology

Protease and Inhibitor MechanismsTGF-β signaling in diseases

Cited by 1,104

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

Coussens, L. M., Raymond, W. W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G. H., & Hanahan, D. (1999) · Genes & Development

Angiogenesis and VEGF in CancerMast cells and histamine

Cited by 946

Circulating Tumor Cells

Plaks, V., Koopman, C. D., & Werb, Z. (2013) · Science

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 722

GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland

Kouros-Mehr, H., Slorach, E. M., Sternlicht, M. D., & Werb, Z. (2006) · Cell

Estrogen and related hormone effectsDevelopmental Biology and Gene Regulation

Cited by 688

Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages

Knighton, D. R., Hunt, T. K., Scheuenstuhl, H., Halliday, B. J., Werb, Z., & Banda, M. J. (1983) · Science

Wound Healing and TreatmentsAngiogenesis and VEGF in Cancer

Cited by 685

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

McGinnis, C. S., Patterson, D. M., Winkler, J., Conrad, D. N., Hein, M. Y., Srivastava, V., Hu, J. L., Murrow, L. M., Weissman, J. S., Werb, Z., et al. (2019) · Nature Methods

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 643

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., & Thompson, E. W. (2009) · Arthritis & Rheumatism

Osteoarthritis Treatment and MechanismsProtease and Inhibitor Mechanisms

Cited by 642

Tumour heterogeneity and metastasis at single-cell resolution

Lawson, D. A., Kessenbrock, K., Davis, R. T., Pervolarakis, N., & Werb, Z. (2018) · Nature Cell Biology

Single-cell and spatial transcriptomicsCancer Genomics and Diagnostics

Cited by 606

Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones

Engsig, M. T., Chen, Q.-J., Vu, T. H., Pedersen, A.-C., Therkidsen, B., Lund, L. R., Henriksen, K., Lenhard, T., Foged, N. T., Werb, Z., et al. (2000) · The Journal of Cell Biology

Bone Metabolism and DiseasesProtease and Inhibitor Mechanisms

Cited by 596