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Evaluating the potential of Vitamin D and curcumin to alleviate inflammation and mitigate the progression of osteoarthritis through their effects on human chondrocytes: A proof-of-concept investigation

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Urokinase Plasminogen Activator System in Synovial Fibroblasts from Osteoarthritis Patients: Modulation by Inflammatory Mediators and Neuropeptides

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Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model

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Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis

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Abnormal bone quality in cartilage oligomeric matrix protein and matrilin 3 double‐deficient mice caused by increased tissue inhibitor of metalloproteinases 3 deposition and delayed aggrecan degradation

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Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat

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Serum trace elements and osteoarthritis: A meta-analysis and Mendelian randomization study

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PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice

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The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease

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L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis

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Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease

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The potential role of protease systems in hemophilic arthropathy

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Anti-Apoptotic Effects of Docosahexaenoic Acid in IL-1β-Induced Human Chondrosarcoma Cell Death through Involvement of the MAPK Signaling Pathway

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Exacerbation of Aging‐Associated and Instability‐Induced Murine Osteoarthritis With Deletion of D Prostanoid Receptor 1, a Prostaglandin D 2 Receptor

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A whole‐joint histopathologic grading system for murine knee osteoarthritis

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MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients

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The influence of zinc levels on osteoarthritis: A comprehensive review

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Role of Lipocalin‐Type Prostaglandin D Synthase in Experimental Osteoarthritis

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Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1

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A MODIFIED COMPREHENSIVE GRADING SYSTEM FOR MURINE KNEE OSTEOARTHRITIS: SCORING THE WHOLE JOINT AS AN ORGAN

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Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model

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Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine

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SNIP1 reduces extracellular matrix degradation and inflammation via inhibiting the NF-κB signaling pathway in osteoarthritis

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Are cellular mechanosensors potential therapeutic targets in osteoarthritis?

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DAla2GIP antagonizes H2O2-induced chondrocyte apoptosis and inflammatory factor secretion

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The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats

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Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development

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Inhibition of matrix metalloproteinase-13 expression in IL-1β-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action

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A Molecular Cascade Underlying Articular Cartilage Degeneration

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Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

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Antiangiogenic Effect of Dopamine and Dopaminergic Agonists as an Adjuvant Therapeutic Option in the Treatment of Cancer, Endometriosis, and Osteoarthritis

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Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis

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Chopping off the chondrocyte proteome

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CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis

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Dual protective role of velutin against articular cartilage degeneration and subchondral bone loss via the p38 signaling pathway in murine osteoarthritis

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Studying Osteoarthritis Pathogenesis in Mice

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Effect of whole body vibration on HIF-2α expression in SD rats with early knee osteoarthritis

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Targeting Discoidin Domain Receptor 2 for the Development of Disease-Modifying Osteoarthritis Drugs

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The interactions between extracellular vesicles and mesenchymal stem cells: Their potential roles in osteoarthritis development and cartilage repair

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Anti-Inflammatory, Analgesic, Functional Improvement, and Chondroprotective Effects of Erigeron breviscapus (Vant.) Hand.-Mazz. Extract in Osteoarthritis: An In Vivo and In Vitro Study

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Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges

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GSK5182, 4-Hydroxytamoxifen Analog, a New Potential Therapeutic Drug for Osteoarthritis

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Preventative treatment of red light-emitting diode protected osteoarthritis-like chondrocytes from oxidative stress-induced inflammation and promoted matrix gene expression

Chen, I.-C., Su, C., Fang, C.-H., & Fang, H. (2021) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2021.07.037 · Cited by 10

Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities

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Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis

Ozkan, H., Francesco, M. D., Willcockson, H. H., Valdés‐Fernández, J., Francesco, V. D., Granero‐Moltó, F., Prósper, F., Decuzzi, P., & Longobardi, L. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01235-1 · Cited by 10

Cartilage and Chondrocytes

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Correlation Between Synovial Fluid Levels of Matrix Metalloproteinase’s (MMP-1, MMP-3, and MMP-9) and TNF-α with the Severity of Osteoarthritis Knee in Rural Indian Population

Kumar, S., Kumar, H., Mittal, A., Singh, P. P., Yadav, V., Kumar, D., Ahmad, I., & Mishra, V. (2023) · Indian Journal of Orthopaedics · doi:10.1007/s43465-023-00974-8 · Cited by 9

Fibroblast growth factor 7 (FGF7) causes cartilage destruction, subchondral bone remodeling, and the premature growth plate closure in mice

Shin, Y., Kwak, J.-S., Kim, S. K., & Chun, J. (2024) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2024.11.010 · Cited by 9

Osteoprotegerin deficiency leads to deformation of the articular cartilage in femoral head

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FAK inhibition protects condylar cartilage under excessive mechanical stress

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Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

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MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy

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Evaluation of correlation of articular cartilage staining for DDR2 and proteoglycans with histological tissue damage and the results of radiographic assessment in patients with early stages of knee osteoarthritis.

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Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis

Takahata, Y., Murakami, T., Hata, K., & Nishimura, R. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200417122933 · Cited by 9

TSG‐6 Is Weakly Chondroprotective in Murine OA but Does not Account for FGF2‐Mediated Joint Protection

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Acacetin Suppresses IL‐1β‐Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF‐κB Signaling Pathways

Chen, J., Wang, C., Huang, K., Chen, S., & Ma, Y. (2020) · BioMed Research International · doi:10.1155/2020/2328401 · Cited by 9

Monocytes, Macrophages and Joint Inflammation in Osteoarthritis

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A review of periostin in orthopedics

Wishman, M. D., Sgrignoli, W. M., Patterson, B. M., Nepola, J. V., Wolf, B. R., Bozoghlian, M. F., Lane, C. M., Coleman, M. C., & Galvin, J. W. (2025) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2025.100600 · Cited by 8

In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis

Platzer, H., Wellbrock, M., Pourbozorg, G., Mayakrishnan, R., Gantz, S., Khamees, B., Simon, M. J. K., & Moradi, B. (2025) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2025.100642 · Cited by 8

Multifunctional Biomimetic Nanomedicine for Osteoarthritis Alleviation by Mitigating Cartilage Degeneration and Promoting Cartilage Regeneration

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Lutein attenuates rheumatoid arthritis progression by suppressing MAPK/NF-κB signaling and MMP3 and MMP13 expression in fibroblast-like Synoviocytes

Chang, C., Chang, T.-M., Sun, Y.-S., Lin, J., Lee, C., Fang, M.-L., & Liu, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115360 · Cited by 8

Early ablation of Ccr2 in aggrecan-expressing cells following knee injury ameliorates joint damage and pain during post-traumatic osteoarthritis

Willcockson, H. H., Ozkan, H., Arbeeva, L. S., Mucahit, E., Musawwir, L., & Longobardi, L. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.08.015 · Cited by 8

Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue

Green, J., Tinson, R., Betts, J. H. J., Piras, M., Pelut, A., Steverding, D., Wren, S. P., Searcey, M., & Troeberg, L. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117424 · Cited by 8

Experimental chondrocyte hypertrophy is promoted by the activation of discoidin domain receptor 2

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Intra-Articular Administration of Cramp into Mouse Knee Joint Exacerbates Experimental Osteoarthritis Progression

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Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

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Relationship between Oxytocin and Osteoarthritis: Hope or Despair?

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