CoChat
Sign Up
Cited by 81Systemic Lupus Erythematosus ResearchAutism Spectrum Disorder ResearchMaternal Mental Health During Pregnancy and Postpartum

Increased Risk of Autism Spectrum Disorders in Children Born to Women With Systemic Lupus Erythematosus: Results From a Large Population‐Based Cohort

Vinet, Évelyne, Pineau, Christian A., Clarke, Ann E., Scott, Susan, Fombonne, Éric, Joseph, Lawrence, Platt, Robert W., Bernatsky, Sasha·2015·Arthritis & Rheumatology
DOI 10.1002/art.39320
Open this paper in CoChat — free account

Abstract

Objective: In utero exposure to maternal antibodies and cytokines are potential risk factors for autism spectrum disorders (ASDs). The aim of this study was to determine whether children born to mothers with systemic lupus erythematosus (SLE) have an increased risk of ASD compared to children born to mothers without SLE. Methods: The study population was derived from the Offspring of SLE Mothers Registry (OSLER), a large population‐based cohort identified through healthcare databases in Quebec (1989–2009) comprising all women who had ≥1 hospitalization for a delivery (stillbirth or live birth) after SLE diagnosis. As general population controls, a randomly selected group of women without SLE was matched ≥4:1 to the mothers with SLE for age and year of delivery. Children born live to mothers with SLE and those born live to matched controls were identified, and a recorded diagnosis of ASD was ascertained for each child. Multivariate analyses were performed to adjust for parents’ demographic characteristics, sex, birth order of the child, maternal comorbidities, and obstetric complications. Results: In total, 509 women with SLE had 719 children, and 5,824 matched controls had 8,493 children. Children born to women with SLE were more frequently found to have a diagnosis of ASD compared to controls (frequency of recorded ASDs 1.4% [95% confidence interval (95% CI) 0.8–2.5] versus 0.6% [95% CI 0.5–0.8]), a difference of 0.8% (95% CI 0.1–1.9). The mean age at ASD diagnosis was younger in offspring of SLE mothers (mean 3.8 years, 95% CI 1.8–5.8) compared to offspring of controls (mean 5.7 years, 95% CI 4.9–6.5). In primary multivariate analysis, SLE offspring had a substantially increased risk of ASD compared to controls (odds ratio 2.19, 95% CI 1.09–4.39). Conclusion: Compared to children from the general population, children born to women with SLE have an increased risk of ASD, although, in absolute terms, it represents a rare outcome. These hypothesis‐generating data provide direction for additional studies of maternal autoimmunity and ASD risk.

Integrity signals

Registry

Crossref · 10.1002/art.39320

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A 2015 study found more than double the risk of ASD in children of mothers with SLE than in controls.

    “including a 2015 study that found a more than double risk of ASD in children of mothers with SLE than those of controls (Vinet et al, 2015).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Vinet et al, 2015

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Vinet, É., Pineau, C. A., Clarke, A. E., Scott, S., Fombonne, É., Joseph, L., Platt, R. W., & Bernatsky, S.
Affiliations
  • McGill University Health Centre (CA)
  • University of Calgary (CA)
  • Oregon Health & Sciences University Portland
  • McGill University (CA)
Corresponding author
Bernatsky, Sasha
ORCID
Venue
Arthritis & Rheumatology
Publisher
Wiley
Published
2015-11-25
Volume
67
Issue
12
Pages
3201-3208
ISSN
  • 2326-5191 (ISSN-L)
  • 2326-5205
DOI
10.1002/art.39320
OpenAlex
W2187257633
Cited by
81
References
36
Citations by year
2026: 3 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 1
FWCI
6.72
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Arthritis & Rheumatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes for Health Research (CIHR operating grant: Obstetrical Complications and Long-Term Outcomes of Children Born to Women with SLE)
  • Canadian Institutes for Health Research Fellowship and a Fonds de Recherche en Santé du Québec Fellowship
  • Arthritis Society Chair in Rheumatology and Rheumatic Diseases at the University of Calgary
  • Fonds de Recherche en Santé du Québec Career Award
  • Canadian Institutes for Health Research Junior Investigator Award
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
autism spectrum disorder, systemic lupus erythematosus, maternal autoimmunity, prenatal exposure, maternal antibodies, cytokines, offspring risk, autism risk factors, maternal comorbidities, pregnancy complications, birth cohort, stillbirth, live birth
MeSH terms
Autism Spectrum Disorder, Adult, Bayes Theorem, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Infant, Small for Gestational Age, Lupus Erythematosus, Systemic, Male, Pregnancy, Pregnancy Complications, Quebec, Risk Factors, Cohort Studies, Multivariate Analysis, Logistic Models, Case-Control Studies, Diabetes, Gestational

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review