The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology
Abstract
Cys‐tematic modification: Cysteine is a versatile amino acid for selective chemical modification of proteins. Both chemical and biological innovations made possible by cysteine modification are highlighted in this Focus Review.magnified image Chemical modification of proteins is a rapidly expanding area in chemical biology. Selective installation of biochemical probes has led to a better understanding of natural protein modification and macromolecular function. In other cases such chemical alterations have changed the protein function entirely. Additionally, tethering therapeutic cargo to proteins has proven invaluable in campaigns against disease. For controlled, selective access to such modified proteins, a unique chemical handle is required. Cysteine, with its unique reactivity, has long been used for such modifications. Cysteine has enjoyed widespread use in selective protein modification, yet new applications and even new reactions continue to emerge. This Focus Review highlights the enduring utility of cysteine in protein modification with special focus on recent innovations in chemistry and biology associated with such modifications.
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Adding New Chemistries to the Genetic Code
Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Methods for converting cysteine to dehydroalanine on peptides and proteins
Chalker, J. M., Gunnoo, S. B., Boutureira, O., Gerstberger, S. C., Fernández-González, M., Bernardes, G. J. L., Griffin, L., Hailu, H., Schofield, C. J., & Davis, B. G. (2011) · Chemical Science · doi:10.1039/c1sc00185j · Cited by 367
Self-citationTamura, T., & Hamachi, I. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11747 · Cited by 339
Boronic acids as building blocks for the construction of therapeutically useful bioconjugates
António, J. P. M., Russo, R., Carvalho, C. P., Cal, P. M. S. D., & Gois, P. M. P. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00184k · Cited by 303
Metadata
- Authors
- Chalker, J. M., Bernardes, G. J. L., Lin, Y. A., & Davis, B. G.
- Venue
- Chemistry – An Asian Journal
- Publisher
- Wiley
- Published
- 2009-04-28
- Volume
- 4
- Issue
- 5
- Pages
- 630-640
- ISSN
- 1861-471X (ISSN-L)
- 1861-4728
- OpenAlex
- W1963683058
- Cited by
- 649
- References
- 72
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chalker, J. M., Bernardes, G. J. L., Lin, Y. A., & Davis, B. G. (2009). Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology. Chemistry – An Asian Journal. https://doi.org/10.1002/asia.200800427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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