Handbook of Metathesis: Catalyst Development

Abstract

Preface.CATALYST DEVELOPMENTS.Introduction.The Role of the Tebbe in Olefin Metathesis.The Discovery and Development of High Oxidation State Mo and W Imido Alkylidene Complexes for Alkene Metathesis.From ill-defined to well-defined W alkylidene complexes.Discovery of Well-defined Ruthenium Olefin Metathesis Catalysts.Synthesis of Ruthenium Carbene Complexes.ynthesis of Rhodium and Ruthenium Carbene Complexes with a 16-Electron Count.Mechanism of Ruthenium-Catalyzed Olefin Metathesis Reactions.Intrinsic Reactivity of Ruthenium Carbenes.The Discovery and Development of High Oxidation State Alkylidyne Complexes for Alkyne Metathesis.Well-defined Metallocarbenes and Metallocarbynes Supported on Oxide Support prepared via Surface Organometallic Chemistry.APPLICATIONS IN ORGANIC SYNTHESIS.Introduction.General Ring-Closing Metathesis.Catalytic Asymmetric Olefin Metathesis.Tandem RCM.Ene-Yne Metathesis.Ring Opening Cross Metathesis.Ring Expansion Metathesis Reactions.Olefin Cross-Metathesis.The Olefin Metathesis Reaction in Complex Molecule Construction.Applications of Ring Closing Metathesis to Alkaloid Synthesis.Radicicol and the Epothilones: Total Synthesis of Novel Anti Cancer Agents Using Ring Closing Metathesis.The Use of Olefin Metathesis in Combinatorial Chemistry: Supported and Chromatography-Free Syntheses.Metal-Catalyzed Olefin Metathesis in Metal Coordination Spheres.Alkyne Metathesis.Metathesis of silicon-containing olefins.Commercial Applications of Ruthenium Metathesis Processes.POLYMER SYNTHESIS.Introduction.Living Ring-Opening Olefin Metathesis Polymerization.Synthesis of Copolymers.Conjugated polymers.Stereochemistry of ROMP.Syntheses and Applications of Bioactive Polymers Generated by the Ring-Opening Metathesis Polymerization (ROMP).Metathesis Polymerization: A Versatile Tool for the Synthesis of Surface-Functionalized Supports and Monolithic Materials.Telechelic Polymers from Olefin Metathesis Methodologies.ADMET Polymerization.Acyclic Diyne Metathesis Utilizing in Situ Transition Metal Catalysts: An Efficient Access to Alkyne-Bridged Polymers.Polymerization of Substituted Acetylenes.Commercial Applications.