Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems

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Protein Organic Chemistry and Applications for Labeling and Engineering in Live‐Cell Systems

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Chemo- and Regioselective Lysine Modification on Native Proteins

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Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin

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LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions

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Ligand-directed tosyl chemistry for in situ native protein labeling and engineering in living systems: from basic properties to applications

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A Three‐Component Organometallic Tyrosine Bioconjugation

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A conditional proteomics approach to identify proteins involved in zinc homeostasis

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Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems

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A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues

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Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody

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Semisynthetic Lectin–4-Dimethylaminopyridine Conjugates for Labeling and Profiling Glycoproteins on Live Cell Surfaces

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Chemical Profiling of the Endoplasmic Reticulum Proteome Using Designer Labeling Reagents

Fujisawa, A., Tamura, T., Yasueda, Y., Kuwata, K., & Hamachi, I. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08606 · Cited by 59 · see citing works

Live‐Cell Protein Sulfonylation Based on Proximity‐drivenN‐Sulfonyl Pyridone Chemistry

Matsuo, K., Nishikawa, Y., Masuda, M., & Hamachi, I. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201707972 · Cited by 58 · see citing works

Quantitative comparison of protein dynamics in live cells and in vitro by in-cell 19F-NMR

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A Naturally Encoded Dipeptide Handle for Bioorthogonal Chan–Lam Coupling

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One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method

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Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells

Amaike, K., Tamura, T., & Hamachi, I. (2017) · Chemical Communications · doi:10.1039/c7cc07177a · Cited by 46 · see citing works

Mechanisms of chemical protein 19 F-labeling and NMR-based biosensor construction in vitro and in cells using self-assembling ligand-directed tosylate compounds

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Organelle‐Specific Activity‐Based Protein Profiling in Living Cells

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Synthetic Chromatin Acylation by an Artificial Catalyst System

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Molecular recognition in protein modification with rhodium metallopeptides

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A Vinylogous Photocleavage Strategy Allows Direct Photocaging of Backbone Amide Structure

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In Situ Construction of Protein-Based Semisynthetic Biosensors

Ueda, T., Tamura, T., & Hamachi, I. (2018) · ACS Sensors · doi:10.1021/acssensors.7b00894 · Cited by 30 · see citing works

Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules

Yasueda, Y., Tamura, T., & Hamachi, I. (2015) · Chemistry Letters · doi:10.1246/cl.151083 · Cited by 22 · see citing works

Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

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Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry

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In Situ Protein Labeling in Complex Environments

Tamura, T., Shigemitsu, H., & Hamachi, I. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12553-3 · Cited by 2 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

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Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation

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Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30

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Modification-specific proteomics: systematic strategies for analysing post-translationally modified proteins

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Current strategies and findings in clinically relevant post-translational modification-specific proteomics

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An overview of proteomics approaches applied to biopharmaceuticals and cyclotides research

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Getting a chemical handle on proteinpost-translational modification

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Chemical biology approaches for studying posttranslational modifications

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