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Cited by 104Pregnancy and preeclampsia studiesBirth, Development, and HealthGestational Diabetes Research and Management

Placental growth patterns affect birth weight for given placental weight

Salafia, Carolyn M., Zhang, Jun, Miller, Richard K., Charles, Adrian K., Shrout, Patrick, Sun, Wenyu·2007·Birth Defects Research Part A: Clinical and Molecular Teratology
DOI 10.1002/bdra.20345
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Abstract

BACKGROUND: An important contributor to fetal growth is growth of the placenta, the fetus' sole source of nutrients and oxygen. Here we use placental growth measures (larger and smaller disk diameters, reflecting the laterally expanding chorionic plate, and disk thickness) to test the hypothesis that placental growth patterns, while associated with placental weight and birth weight, measure placental functional efficiency, and will have independent effects on the feto‐placental weight ratio (FPR). METHODS: Placental measures were available from 23,313 participants in the Collaborative Perinatal Project delivered between 34 and 43 completed weeks. Continuous variables were analyzed by regression for associations with placental weight, birth weight, and FPR, to further explore effects of placental growth patterns on the FPR (lateral chorionic plate growth and chorionic disk thickness were grouped as low, normal, and high values). The relationships of the nine resultant combinations of placental growth categories to the FPR using birth weight adjusted for gestational age, infant gender, parity, and African American race were analyzed (ANOVA). RESULTS: As chorionic disk area and thickness increased, birth weight and placental weight increased, and the FPR decreased (each p < .0001) after adjustment for gestational age, parity, race, and infant gender. Small, thin placental disks had an adjusted FPR of 8.46; the largest, thickest placentas had an adjusted FPR of 6.33. The nine categories of FPRs were significantly different, consistent with chorionic plate area and disk thickness combining to determine the FPR. CONCLUSIONS: Patterns of placental growth, relating to different functional dimensions of the placenta, deliver a different birth weight for a given placental weight. Birth Defects Research (Part A) 2007. © 2007 Wiley‐Liss, Inc.

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  • In humans, large placentas tend to be less efficient than smaller ones.

    “In the human, large placentas tend to less efficient than smaller ones (384, 480), suggesting adaptations, such as changes in transporter expression, have been successful in the latter.”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [480]

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Authors
Salafia, C. M., Zhang, J., Miller, R. K., Charles, A. K., Shrout, P., & Sun, W.
Affiliations
  • New York University (US)
  • National Institutes of Health (US)
  • University of Rochester Medicine (US)
ORCID
Venue
Birth Defects Research Part A: Clinical and Molecular Teratology
Publisher
Wiley
Published
2007-02-07
Volume
79
Issue
4
Pages
281-288
ISSN
  • 1542-0752 (ISSN-L)
  • 1542-0760
DOI
10.1002/bdra.20345
OpenAlex
W2125491239
Cited by
103
References
25
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 8
FWCI
6.62
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Birth Defects Research Part A Clinical and Molecular Teratology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders
National Institute of Mental Health (K23MH067857)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
placental development, birth weight, placental weight, chorionic plate, fetal growth, Collaborative Perinatal Project
MeSH terms
Birth Weight, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Models, Biological, Organ Size, Placentation, Pregnancy, Regression Analysis

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