Gross placental measures and childhood growth
Open accessAbstract
OBJECTIVES: We hypothesised that the gross placental measures would be positively associated with childhood growth. METHODS: We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7. RESULTS: Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (beta = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (beta = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: beta = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005). CONCLUSIONS: Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.
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Abnormalities in gross placental development are linked to adverse pregnancy outcomes such as preeclampsia and intrauterine growth restriction.
“Mounting evidence [1,2,3] has linked abnormalities in gross placental development to such outcomes.”
From Fully Automated Placental Volume Quantification From<scp>3D</scp>Ultrasound for Prediction of Small‐for‐Gestational‐Age Infants (2022) · cites this paper as [1]
Placental size and shape are significantly associated with perinatal outcomes and fetal programming.
“Researchers have observed that placental size and shape are significantly associated with perinatal outcomes and fetal programming. 1 -3”
From Minimally interactive placenta segmentation from three-dimensional ultrasound images (2020) · cites this paper as [3]
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Combining Deep Learning and Multi-atlas Label Fusion for Automated Placenta Segmentation from 3DUS
Oguz, B. U., Wang, J., Yushkevich, N., Pouch, A., Gee, J., Yushkevich, P. A., Schwartz, N., & Oguz, I. (2018) · Lecture Notes in Computer Science · doi:10.1007/978-3-030-00807-9_14 · Cited by 13 · see citing works
Minimally interactive placenta segmentation from three-dimensional ultrasound images
Oguz, I., Yushkevich, N., Pouch, A. M., Oguz, B. U., Wang, J., Parameshwaran, S., Gee, J. C., Yushkevich, P. A., & Schwartz, N. (2020) · Journal of Medical Imaging · doi:10.1117/1.jmi.7.1.014004 · Cited by 13 · see citing works
Schwartz, N., Oguz, I., Wang, J., Pouch, A., Yushkevich, N., Parameshwaran, S., Gee, J., Yushkevich, P., & Oguz, B. (2022) · Journal of Ultrasound in Medicine · doi:10.1002/jum.15835 · Cited by 11 · see citing works
- Authors
- Baptiste-Roberts, K., Salafia, C. M., Nicholson, W. K., Duggan, A., Wang, N.-Y., & Brancati, F. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Baptiste-Roberts, Kesha
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 22
- Issue
- 1
- Pages
- 13-23
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- PMC
- PMC3713228
- OpenAlex
- W2024782412
- Cited by
- 30
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32 HL 07024, T32HL007024)
- National Institute of Mental Health (K23MH067857)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24-DK62222, K23DK067944, K24DK062222, R24DK084949, P30DK079637)
- National Center for Research Resources (M01RR002719, M0-1-RR-02719)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- placental weight, placental size, child growth, birth weight, body mass index, racial differences, Collaborative Perinatal Project, placental structure
- MeSH terms
- Adult, Birth Weight, Child, Child Development, Child, Preschool, Ethnicity, Female, Follow-Up Studies, Humans, Infant, Newborn, Male, Organ Size, Placentation, Pregnancy, Social Class, Body Mass Index, Maternal-Fetal Relations, Young Adult
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