The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Epigenomic disruption: The effects of early developmental exposures
Open accessAbstract
Through DNA methylation, histone modifications, and small regulatory RNAs the epigenome systematically controls gene expression during development, both in utero and throughout life. The epigenome is also a very reactive system; its labile nature allows it to sense and respond to environmental perturbations to ensure survival during fetal growth. This pliability can lead to aberrant epigenetic modifications that persist into later life and induce numerous disease states. Endocrine‐disrupting compounds (EDCs) are ubiquitous chemicals that interfere with growth and development. Several EDCs also interfere with epigenetic programming. The investigation of the epigenotoxic effects of bisphenol A (BPA), an EDC used in the production of plastics and resins, has further raised concern over the impact of EDCs on the epigenome. Using the Agouti viable yellow (Avy) mouse model, dietary BPA exposure was shown to hypomethylate both the Avy and the CabpIAP metastable epialleles. This hypomethylating effect was counteracted with dietary supplementation of methyl donors or genistein. These results are consistent with reports of BPA and other EDCs causing epigenetic effects. Epigenotoxicity could lead to numerous developmental, metabolic, and behavioral disorders in exposed populations. The heritable nature of epigenetic changes also increases the risk for transgenerational inheritance of phenotypes. Thus, epigenotoxicity must be considered when assessing these compounds for safety. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.
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Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Self-citationTransposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · cited 4×
“…characteristics: 1) they are established in a stochastic manner (Morgan and others, 1999), 2) they are potentially inherited transgenerationally (Rakyan and others, 2003), and 3) their establishment can be altered by environmental agents, such as food supplements (Waterland and Jirtle, 2003).”
BackgroundMethodInfluentialEpigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476
Dolinoy, D. C., Huang, D., & Jirtle, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703739104 · Cited by 1,369
Self-citationHo, S.-M., Tang, W.-Y., Belmonte de Frausto, J., & Prins, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0516 · Cited by 796
Epigenetics: a molecular link between environmental factors and type 2 diabetes
Ling, C., & Groop, L. (2009) · Diabetes · doi:10.2337/db09-1003 · Cited by 617
Prenatal bisphenol A exposure and early childhood behavior.
Braun, J. M., Yolton, K., Dietrich, K. N., Hornung, R., Ye, X., Calafat, A. M., & Lanphear, B. P. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900979 · Cited by 481
Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat
Somm, E., Schwitzgebel, V. M., Toulotte, A., Cederroth, C. R., Combescure, C., Nef, S., Aubert, M. L., & Hüppi, P. S. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.11342 · Cited by 467
Cited by
Endocrine disruptors and obesity
Heindel, J. J., Newbold, R., & Schug, T. T. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.163 · Cited by 451
Faulk, C., & Dolinoy, D. C. (2011) · Epigenetics · doi:10.4161/epi.6.7.16209 · Cited by 386
Physiological consequences of heat stress in pigs
Ross, J. W., Hale, B. J., Gabler, N. K., Rhoads, R. P., Keating, A. F., & Baumgard, L. H. (2015) · Animal Production Science · doi:10.1071/an15267 · Cited by 202
High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations
Jang, Y. J., Park, H. R., Kim, T. H., Yang, W.-J., Lee, J.-J., Choi, S. Y., Oh, S. B., Lee, E., Park, J.-H., Kim, H.-P., et al. (2012) · Toxicology · doi:10.1016/j.tox.2012.03.007 · Cited by 82
Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene
Kurita, H., Ohsako, S., Hashimoto, S.-I., Yoshinaga, J., & Tohyama, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.05.013 · Cited by 45
Metadata
- Authors
- Bernal, A. J., & Jirtle, R. L.
- Venue
- Birth Defects Research Part A: Clinical and Molecular Teratology
- Publisher
- Wiley
- Published
- 2010-06-21
- Volume
- 88
- Issue
- 10
- Pages
- 938-944
- ISSN
- 1542-0752 (ISSN-L)
- 1542-0760
- OpenAlex
- W1963466636
- Cited by
- 234
- References
- 12
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- green
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