Prenatal bisphenol A exposure and early childhood behavior.
Open accessAbstract
Background: Prenatal exposure to bisphenol A (BPA) increases offspring aggression and diminishes differences in sexually dimorphic behaviors in rodents. Objective: We examined the association between prenatal BPA exposure and behavior in 2-year-old children. Methods: We used data from 249 mothers and their children in Cincinnati, Ohio (USA). Maternal urine was collected around 16 and 26 weeks of gestation and at birth. BPA concentrations were quantified using high-performance liquid chromatography–isotope-dilution tandem mass spectrometry. Child behavior was assessed at 2 years of age using the second edition of the Behavioral Assessment System for Children (BASC-2). The association between prenatal BPA concentrations and BASC-2 scores was analyzed using linear regression. Results: Median BPA concentrations were 1.8 (16 weeks), 1.7 (26 weeks), and 1.3 (birth) ng/mL. Mean (± SD) BASC-2 externalizing and internalizing scores were 47.6 ± 7.8 and 44.8 ± 7.0, respectively. After adjustment for confounders, log10-transformed mean prenatal BPA concentrations were associated with externalizing scores, but only among females [β = 6.0; 95% confidence interval (CI), 0.1–12.0]. Compared with 26-week and birth concentrations, BPA concentrations collected around 16 weeks were more strongly associated with externalizing scores among all children (β = 2.9; 95% CI, 0.2–5.7), and this association was stronger in females than in males. Among all children, measurements collected at ≤ 16 weeks showed a stronger association (β = 5.1; 95% CI, 1.5–8.6) with externalizing scores than did measurements taken at 17–21 weeks (β = 0.6; 95% CI, −2.9 to 4.1). Conclusions: These results suggest that prenatal BPA exposure may be associated with externalizing behaviors in 2-year-old children, especially among female children.
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In humans, a positive association between gestational levels of BPA in mothers and externalizing behaviors in 2 year old girls has been reported.
“In humans, a positive association between gestational levels of BPA in mothers and externalizing (hyperactivity and aggression) behaviors in 2 year old girls has been reported [19].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [19]
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“In humans, a positive association between gestational levels of BPA in mothers and externalizing (hyperactivity and aggression) behaviors in 2 year old girls has been reported [19].”
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- Authors
- Braun, J. M., Yolton, K., Dietrich, K. N., Hornung, R., Ye, X., Calafat, A. M., & Lanphear, B. P.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Lanphear, Bruce P.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-10-06
- Volume
- 117
- Issue
- 12
- Pages
- 1945-1952
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC2799471
- OpenAlex
- W1965966912
- Cited by
- 481
- References
- 7
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 22 · 2023: 23 · 2022: 13 · 2021: 31 · 2020: 32 · 2019: 23 · 2018: 26 · 2017: 29 · 2016: 41 · 2015: 45 · 2014: 36 · 2013: 42 · 2012: 37
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor, 3006 d)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- U.S. Environmental Protection Agency (P01 ES11261)
- Centers for Disease Control and Prevention (P01 ES11261)
- National Institute of Environmental Health Sciences (P01 ES11261, P01ES011261)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD052468-01, T32HD052468)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- bisphenol A, prenatal exposure, endocrine disruptors, child behavior, externalizing problems, internalizing problems, maternal urine, sex differences, early childhood, developmental neurotoxicity
- MeSH terms
- Bisphenol A Compounds, Adult, Benzhydryl Compounds, Child Behavior, Child, Preschool, Female, Fetus, Humans, Male, Phenols, Pregnancy, Sex Characteristics
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