Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene
Abstract
Zinc (Zn) deficiency in utero has been shown to cause a variety of disease states in children in developing countries, which prompted us to formulate the hypothesis that fetal epigenetic alterations are induced by zinc deficiency in utero. Focusing on metallothionein (MT), a protein that contributes to Zn transport and homeostasis, we studied whether and how the prenatal Zn status affects gene expression. Pregnant mice were fed low-Zn (IU-LZ, 5.0 μg Zn/g) or control (IU-CZ, 35 μg Zn/g) diet ad libitum from gestation day 8 until delivery, with a regular diet thereafter. Bisulfite genomic sequencing for DNA methylation and chromatin immunoprecipitation assay for histone modifications were performed on the MT2 promoter region. We found that 5-week-old IU-LZ mice administered cadmium (Cd) (5.0 mg/kg b.w.) have an elevated abundance of MT2 mRNA compared with IU-CZ mice. Alteration of histone modifications in the MT2 promoter region having metal responsive elements (MREs) was observed in 1-day-old and 5-week-old IU-LZ mice compared with IU-CZ mice. In addition, prolongation of MTF1 binding to the MT2 promoter region in 5-week-old IU-LZ mice upon Cd exposure is considered to contribute to the enhanced MT2 induction. In conclusion, we found for the first time that Zn deficiency in utero induces fetal epigenetic alterations and that these changes are being stored as an epigenetic memory until adulthood.
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In one study, fetal zinc deficiency-induced epigenetic alterations in the gene coding for the metal transporter, metallothionein-2.
“In the case of MZ twins sharing a placenta, external stressors that affect only one twin may induce epigenetic modification; notably, in one study fetal zinc deficiency-induced epigenetic alterations in the gene coding for the metal transporter, metallothionein-2 (ref. 37).”
From Fetal and postnatal metal dysregulation in autism (2017) · cites this paper as [37]
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- Authors
- Kurita, H., Ohsako, S., Hashimoto, S.-I., Yoshinaga, J., & Tohyama, C.
- Affiliations
- Center for Disease Biology and Integrative Medicine, The University of Tokyo (JP)
- The University of Tokyo (JP)
- Corresponding author
- Tohyama, Chiharu
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 24
- Issue
- 1
- Pages
- 256-266
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2038340007
- Cited by
- 45
- References
- 51
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 10 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23658237, 23310044)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- metallothionein-2, epigenetic memory, DNA methylation, histone modifications, metal-responsive elements, cadmium exposure, zinc homeostasis, fetal programming, promoter, mouse model
- MeSH terms
- Transcription Factor MTF-1, Animals, Cadmium, DNA-Binding Proteins, Female, Gene Expression Regulation, Histones, Liver, Male, Metallothionein, Mice, Inbred C57BL, Pregnancy, Prenatal Exposure Delayed Effects, Promoter Regions, Genetic, Transcription Factors, Zinc, CpG Islands, DNA Methylation, Epigenesis, Genetic, Chromatin Immunoprecipitation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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