Increasingly complex: New players enter the Wnt signaling network
Abstract
Wnt proteins can activate different intracellular signaling cascades in various organisms by interacting with receptors of the Frizzled family. The first identified Wnt signaling pathway, the Wnt/β‐catenin pathway, has been studied in much detail and is highly conserved among species. As to non‐canonical Wnt pathways, the current situation is more nebulous partly because the intracellular mediators of this pathway are not yet fully understood and, in some cases, even identified. However, there are increasing data that prove the existence of non‐canonical Wnt signaling and demonstrate its involvement in different developmental processes. In vertebrates, Wnt‐11 and Wnt‐5A can activate the Wnt/JNK pathway, which resembles the planar cell polarity pathway in Drosophila. The Wnt/Ca 2+‐pathway has only been described in Xenopus and zebrafish so far and it is unclear whether it also exists in other organisms. Two recent papers provide us with new insight into non‐canonical Wnt signaling by (1) presenting a new intracellular mediator of non‐canonical signaling in Xenopus1 and (2) implicating the existence of an additional non‐canonical Wnt signaling pathway in flies.2 BioEssays 24:881–884, 2002. © 2002 Wiley Periodicals, Inc.
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Wnt5a can activate the non-canonical pathway and induce calcium flux but not activate β-catenin stabilization.
“Likewise, Wnt5a can activate the non-canonical pathway and induce calcium flux but not activate β-catenin stabilization.91,114”
From Wnt signal transduction pathways (2008) · cites this paper as [114]
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- Authors
- Pandur, P., Maurus, D., & Kühl, M.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Kühl, Michael
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2002-09-25
- Volume
- 24
- Issue
- 10
- Pages
- 881-884
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2146026996
- Cited by
- 188
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 1 · 2017: 12 · 2016: 4 · 2015: 11 · 2014: 3 · 2013: 8 · 2012: 5
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BioEssays (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, non-canonical Wnt pathway, Wnt/β-catenin signaling, Frizzled receptors, Wnt5a, planar cell polarity, Wnt/Ca2+ pathway, Xenopus, Drosophila, developmental processes
- MeSH terms
- Animals, Calcium, Cell Movement, DNA-Binding Proteins, Drosophila, Ligands, Membrane Proteins, Models, Biological, Nuclear Proteins, Protein Kinase C, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Transcription Factors, Xenopus, Signal Transduction, Calcineurin, Drosophila Proteins, Xenopus Proteins, Zebrafish Proteins, Receptors, G-Protein-Coupled, NFATC Transcription Factors, Wnt Proteins, Frizzled Receptors, Focal Adhesion Protein-Tyrosine Kinases
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